Regional glycine receptor binding in the p,p′-DDT myoclonic rat model

1992 ◽  
Vol 66 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Michael R. Pranzatelli ◽  
Katie Tkach
Keyword(s):  
Receptor Binding ◽  
Rat Model ◽  
Glycine Receptor

Effect of glycine on the cyclooxygenase pathway of the kidney arachidonic acid metabolism in a rat model of metabolic syndrome

2011 ◽  
Vol 89 (12) ◽  
pp. 899-910 ◽  
Author(s):  
Israel Pérez-Torres ◽  
Blanca Ibarra ◽  
Elizabeth Soria-Castro ◽  
Rocío Torrico-Lavayen ◽  
Natalia Pavón ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Arachidonic Acid ◽  
Rat Model ◽  
Sucrose Solution ◽  
Glycine Receptor ◽  
Renal Perfusion ◽  
Arachidonic Acid Metabolism ◽  
Receptor Expression ◽  
Model Assessment ◽  
Protective Effects

The kidneys are organs that can be severely impaired by metabolic syndrome (MS). This is characterized by the association of various pathologies such as hypertension, dyslipidemia, and type-2 diabetes. Glycine, a nonessential amino acid, is known to possess various protective effects in the kidney, such as a decrease in the deterioration of renal function and a reduction of the damage caused by hypoxia. In a rat model of MS, the effect of glycine on the cyclooxygenase (COX) pathway of arachidonic acid (AA) metabolism was studied in isolated perfused kidney. MS was induced in Wistar rats by feeding them a 30% sucrose solution for 16 weeks. The addition of 1% glycine to their drinking water containing 30% sucrose, for 8 weeks, reduced high blood pressure, triglyceride levels, insulin concentration, homeostatis model assessment (HOMA) index, albuminuria, AA concentration in kidney homogenate, renal perfusion pressure, prostaglandin levels, PLA2expression, and COX isoform expression, compared with MS rats that did not receive the glycine supplement. Glycine receptor expression decreased significantly with MS, but glycine treatment increased it. The results suggest that in the MS model, 1% glycine treatment protects the kidney from damage provoked by the high sucrose consumption, by acting as an anti-inflammatory on the COX pathway of AA metabolism in kidney.

791 Increased Spinal Cord Alpha2-Adrenergic Receptor Binding in a Rat Model of Neuropathic Pain

Neurosurgery ◽  
2000 ◽  
Vol 47 (2) ◽  
pp. 525-526
Author(s):  
James W. Leiphart ◽  
Cynthia Dills ◽  
Robert M. Levy
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Receptor Binding ◽  
Rat Model ◽  
Adrenergic Receptor

Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia

2016 ◽  
Vol 633 ◽  
pp. 87-93 ◽  
Author(s):  
Edina Szűcs ◽  
Szabolcs Dvorácskó ◽  
Csaba Tömböly ◽  
Alexandra Büki ◽  
Gabriella Kékesi ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Rat Model ◽  
Brain Regions
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