Routine compared with nonscheduled follow-up of patients with “curative” surgery for colorectal cancer

1996 ◽  
Vol 3 (5) ◽  
pp. 464-469 ◽  
Author(s):  
Roberto Bergamaschi ◽  
Jean-Pierre Arnaud
Keyword(s):  
Colorectal Cancer ◽  
Curative Surgery

scholarly journals Intensive Follow-Up After Curative Surgery for Colorectal Cancer

2017 ◽  
Vol 30 (9) ◽  
pp. 633 ◽  
Author(s):  
Rita Vale Rodrigues ◽  
João Pereira da Silva ◽  
Isadora Rosa ◽  
Isabel Santos ◽  
Nuno Pereira ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Curative Resection ◽  
Curative Treatment ◽  
Rank Test ◽  
Surveillance Program ◽  
Curative Surgery ◽  
Cancer Antigen ◽  
Chi Square ◽  
Postoperative Surveillance

Introduction: The purpose of postoperative surveillance programs after curative treatment for colorectal cancer is to detect asymptomatic recurrences with the premise that an important rate will be eligible for curative resection, improving overall survival. We have implemented a surveillance program for patients with colorectal cancer, stages II-III, with periodic clinical, carcinoembryonic antigen and cancer antigen-19-9 assessment, computed tomography and colonoscopy. The aim of this study was to assess the rate of curative treatment of recurrence, colorectal cancer mortality and clinical characteristics associated with non-resectable recurrence.Material and Methods: Open cohort study, single center. All patients on the intensive surveillance program between March 2008 and January 2015 were included. Statistics: chi-square, Wilcoxon rank sum test, logistic regression, Kaplan-Meier log-rank test (SPSS20®).Results: We had a total 404 patients evaluated; 59.6% male; mean age of 65 ± 10 years; 50.7% rectal tumor; 56.2% stage III. The average time of follow-up was 37 months and the recurrence rate was 12.9% (n = 52), mostly detected in the first three years (88.4%). The pattern of recurrence was associated with the site of the primary tumor (p < 0.001). Twenty-one patients underwent curative resection. Factors associated with non-resectable recurrence were aged ≥ 70 years (p = 0.022), disease location in the colon (p = 0.033) and cancer antigen-19-9-9 elevation (p = 0.024). The overall rate of cancer-specific mortality was 2.2% (n = 9).Discussion: The association between colon cancer and non-resectable recurrence is explained by the higher rate of disseminated disease in these patients. Cancer antigen-19-9 added no benefit to the surveillance program.Conclusion: This intensive real-world postoperative surveillance program allowed performing curative surgery to 40.3% of patients with recurrence.

scholarly journals Evaluation of appropriate follow-up after curative surgery for patients with colorectal cancer using time to recurrence and survival after recurrence: a retrospective multicenter study

Oncotarget ◽  
2018 ◽  
Vol 9 (39) ◽  
pp. 25474-25490 ◽  
Author(s):  
Tomoki Yamano ◽  
Shinichi Yamauchi ◽  
Kiyoshi Tsukamoto ◽  
Masafumi Noda ◽  
Masayoshi Kobayashi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Multicenter Study ◽  
Curative Surgery ◽  
Time To Recurrence ◽  
Retrospective Multicenter Study

Strict follow-up programme including CT and 18F-FDG-PET after curative surgery for colorectal cancer

2009 ◽  
Vol 12 (10Online) ◽  
pp. e224-e228 ◽  
Author(s):  
N. F. Sørensen ◽  
A. B. Jensen ◽  
P. Wille-Jørgensen ◽  
L. Friberg ◽  
L. Rørdam ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fdg Pet ◽  
Curative Surgery ◽  
18F Fdg

Limitations of CEA Monitoring as a Guide to Second-Look Surgery in Colorectal Cancer Follow-Up

1983 ◽  
Vol 69 (4) ◽  
pp. 359-364 ◽  
Author(s):  
Claudio Fucini ◽  
Maria Silvia Tommasi ◽  
Gaetano Cardona ◽  
Giorgio Malatantis ◽  
Sergio Panichi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Local Recurrence ◽  
Neoplastic Disease ◽  
Curative Surgery ◽  
Negative Results ◽  
Second Look ◽  
Test Specificity ◽  
Good For ◽  
Second Look Operation

Forty-two patients with localized colorectal cancer (Dukes’ A, B, C stages) were treated with potentially curative surgery and controlled with a follow-up program, which included CEA monitoring, for a period ranging from 12 to 48 months (median 33 months). During this period, we observed recurrent neoplastic disease in 14 patients. A retrospective analysis of the results showed that: 1. patients with a preoperative CEA value > 20 ng/ml have a significantly higher risk of recurrence than the patients with CEA < 20 ng/ml; 2. sensitivity of the CEA test was good for metastatic recurrent disease, fairly good for residual neoplastic disease, but insufficient for local recurrence; 3. test-specificity was poor, as demonstrated by the negative results of four exploratory laparotomies performed exclusively on the basis of increased CEA levels. Since the principal aim of a second-look operation is the cure of local recurrence, this type of surgery cannot be proposed only on the basis of increased CEA levels.

Prognostic impact of miR-146 polymorphism in patients with resected colorectal cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 3554-3554
Author(s):  
Jong Gwang Kim ◽  
Yee Soo Chae ◽  
Soo Jung Lee ◽  
Byung Woog Kang ◽  
Joon Ho Moon ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Impact ◽  
Curative Surgery ◽  
Small Noncoding Rnas ◽  
Kaplan Meier ◽  
Pcr Rflp ◽  
Fresh Frozen ◽  
Polymerase Chain ◽  
Regulatory Functions

3554 Background: MicroRNAs (miRNAs) are small noncoding RNAs with regulatory functions as tumor suppressors and oncogenes. The rs2910164 is a C to G polymorphism located within the sequence of miR-164a precursor, which leads to a change from a C:U pair to a G:U mismatch in its stem region. Recent evidence suggested that the rs2910164 SNP in miR-146a was associated with development of familial breast and ovarian cancers, and prostatic cancer. The aim of this study was to investigate the association between this genetic variant and prognosis of colorectal cancer (CRC) operated curatively. Methods: A total of 343 CRC patients underwent curative surgery were consecutively enrolled between 2004 and 2006. DNA was extracted from fresh frozen normal tissue and miR-146 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: With a median follow up of 42.3 months, the combined GG+CG genotype demonstrated a better survival outcome compared with the CC genotype in a Kaplan-Meier survival analysis. Multivariate analysis showed that the G allele of miR-146 was associated with better progression-free and disease-specific survival as a dominant model adjusted to age, sex, histologic grade and stage [HR=0.54 and 0.49; p = 0.018 and 0.025, respectively]. Moreover, the tumors containing the G allele were histologically associated with more prominent lymphovascular invasion. Conclusions: Our results suggest that miR-146 polymorphism is possible prognostic marker in operated CRC patients in Korean.

scholarly journals Serum carcinoembryonic antigen to predict recurrence in the follow-up of patients with colorectal cancer

2019 ◽  
Vol 34 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Winesh Ramphal ◽  
Jeske R.E. Boeding ◽  
Maartje van Iwaarden ◽  
Jennifer M.J. Schreinemakers ◽  
Harm J.T. Rutten ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Disease Free Survival ◽  
Curative Surgery ◽  
Free Survival ◽  
Preoperative Serum ◽  
Serum Carcinoembryonic Antigen ◽  
Postoperative Serum ◽  
Serum Cea ◽  
Disease Free

Introduction: Serum carcinoembryonic (CEA) antigen is used as a diagnostic screening tool during follow-up in colorectal cancer patients. However, it remains unclear whether preoperative serum CEA is a reliable marker in the follow-up to predict recurrence. The aim of the study is to determine the value of elevated pre- and postoperative serum carcinoembryonic antigen levels (CEA > 5 µg/L) as an independent prognostic factor for locoregional and distant recurrence in patients who underwent curative surgery for colorectal cancer. Methods: This single center retrospective observational cohort study includes patients who underwent curative surgery for colorectal cancer between 2005 and 2015 and had pre- and postoperative serum CEA measurements. Five-year disease-free survival and multivariate Cox regression analyses were performed to adjust for confounding factors. Results: Preoperative serum CEA level was measured in 2093 patients with colorectal cancer. No significant association was found between an elevated preoperative serum CEA and locoregional recurrence (adjusted hazard ratio (HR) 1.29 (95% confidence interval (CI) 0.91, 1.84; P=0.26)). However, a significant association was found between an elevated preoperative serum CEA and systemic recurrence (adjusted HR 1.58 (95% CI 1.25, 2.00; P<0.01)]. The five-year disease-free survival was lower in patients with elevated preoperative serum CEA levels ( P<0.01). Postoperative serum CEA level was the most sensitive for hepatic metastases during follow-up (73.3%). Conclusions: The preoperative serum CEA level is an independent prognostic factor for systemic metastasis after curative surgery for colorectal cancer in patients with stage I–III disease. The level is the most sensitive for hepatic metastasis compared to metastasis to other anatomic sites.

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