Neurally mediated hypotension and autonomic dysfunction measured by heart rate variability during head-up tilt testing in children with chronic fatigue syndrome

1998 ◽  
Vol 8 (4) ◽  
pp. 221-230 ◽  
Author(s):  
Julian Stewart ◽  
Amy Weldon ◽  
Nina Arlievsky ◽  
Karl Li ◽  
Jose Munoz
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Chronic Fatigue Syndrome ◽  
Autonomic Dysfunction ◽  
Chronic Fatigue ◽  
Tilt Testing ◽  
Fatigue Syndrome ◽  
Neurally Mediated Hypotension ◽  
Head Up Tilt

A Measure of Heart Rate Variability is Sensitive to Orthostatic Challenge in Women with Chronic Fatigue Syndrome

2003 ◽  
Vol 228 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Yoshiharu Yamamoto ◽  
John J. Lamanca ◽  
Benjamin H. Natelson
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Chronic Fatigue Syndrome ◽  
Coarse Graining ◽  
Chronic Fatigue ◽  
Specific Response ◽  
Spectral Exponent ◽  
Fatigue Syndrome ◽  
Head Up Tilt ◽  
The Difference

The use of symptoms generated by head up tilt (HUT) is not a useful tool in identifying chronic fatigue syndrome (CFS). We investigated whether heart rate variability (HRV) assessed early during HUT might be useful. A sample of 46 female subjects (24 with CFS and 22 sedentary, age-matched healthy controls; CON) who had exhibited no difference in time to syncope during tilt was examined for HRV responses to 10 min of 70° HUT after 5 min of baseline in the supine position. HRV data were analyzed by the method of coarse graining spectral analysis. Variables compared between groups included mean and standard deviation (SDRRI) of RR intervals (RRI), amplitudes of low- (ALF; 0.04–0.15 Hz) and high-frequency (AHF; >0.15 Hz) harmonic as well as aperiodic, fractal (AFR; 1/fβ) spectral components, the spectral exponent β, and the difference in these values between baseline and HUT for each subject. In the supine baseline, only mean RRI was significantly (P< 0.01) lower in CFS than in CON. During HUT, however, mean RRI (P < 0.01), SDRRI, (P < 0.01), AHF (P < 0.05), and AFR (P < 0.01) were significantly lower in CFS than in CON. When the difference in values between baseline and HUT for each subject was examined, only the difference for AFR (ΔAFR) was significantly (P < 0.01) lower in CFS than in CON, suggesting that AFR is a disease-specific response of HRV to HUT. When a cut-off level was set to ΔAFR = –2.7 msec, the sensitivity and the specificity in differentiating CFS from controls were 90% and 72%, respectively. The data suggest that a decrease in aperiodic fractal component of HRV in response to HUT can be used to differentiate patients with CFS from CON.

scholarly journals Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Rosa María Escorihuela ◽  
Lluís Capdevila ◽  
Juan Ramos Castro ◽  
María Cleofé Zaragozà ◽  
Sara Maurel ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Chronic Fatigue Syndrome ◽  
Frequency Domain ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Healthy Controls ◽  
Fatigue Syndrome ◽  
Potential Biomarker ◽  
Fatigue Severity

Abstract Background Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; however, in the literature there are only a few previous studies (most of them inconclusive) on their association with illness-related complaints. To address this issue, we assessed the value of different diurnal HRV parameters as potential biomarker in CFS/ME and also investigated the relationship between these HRV indices and self-reported symptoms in individuals with CFS/ME. Methods In this case–control study, 45 female patients who met the 1994 CDC/Fukuda definition for CFS/ME and 25 age- and gender-matched healthy controls underwent HRV recording-resting state tests. The intervals between consecutive heartbeats (RR) were continuously recorded over three 5-min periods. Time- and frequency-domain analyses were applied to estimate HRV variables. Demographic and clinical features, and self-reported symptom measures were also recorded. Results CFS/ME patients showed significantly higher scores in all symptom questionnaires (p < 0.001), decreased RR intervals (p < 0.01), and decreased HRV time- and frequency-domain parameters (p < 0.005), except for the LF/HF ratio than in the healthy controls. Overall, the correlation analysis reached significant associations between the questionnaires scores and HRV time- and frequency-domain measurements (p < 0.05). Furthermore, separate linear regression analyses showed significant relationships between self-reported fatigue symptoms and mean RR (p = 0.005), RMSSD (p = 0.0268) and HFnu indices (p = 0.0067) in CFS/ME patients, but not in healthy controls. Conclusions Our findings suggest that ANS dysfunction presenting as increased sympathetic hyperactivity may contribute to fatigue severity in individuals with ME/CFS. Further studies comparing short- and long-term HRV recording and self-reported outcome measures with previous studies in larger CFS/ME cohorts are urgently warranted.

Comparison of heart rate variability in patients with chronic fatigue syndrome and controls

1997 ◽  
Vol 7 (6) ◽  
pp. 293-297 ◽  
Author(s):  
A. Yataco ◽  
H. Talo ◽  
P. Rowe ◽  
D. A. Kass ◽  
R. D. Berger ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Fatigue Syndrome
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