Laminar distribution of the cells of origin of the spinocerebral pathways involved in nociceptive transmission and pain modulation in the rat

1996 ◽  
Vol 28 (2-3) ◽  
pp. 111-118 ◽  
Author(s):  
G. Kayalioglu ◽  
N. I. Hariri ◽  
F. Govsa ◽  
B. Erdem ◽  
G. Peker ◽  
...  
Keyword(s):  
Pain Modulation ◽  
Nociceptive Transmission ◽  
Cells Of Origin ◽  
Laminar Distribution

scholarly journals Understanding Central Mechanisms of Acupuncture Analgesia Using Dynamic Quantitative Sensory Testing: A Review

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Jiang-Ti Kong ◽  
Rosa N. Schnyer ◽  
Kevin A. Johnson ◽  
Sean Mackey
Keyword(s):  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Acupuncture Analgesia ◽  
Mechanistic Studies ◽  
Sensory Testing ◽  
Descending Inhibition ◽  
Future Directions ◽  
Nociceptive Transmission ◽  
Clinical Pain ◽  
Neurophysiological Data

We discuss the emerging translational tools for the study of acupuncture analgesia with a focus on psychophysical methods. The gap between animal mechanistic studies and human clinical trials of acupuncture analgesia calls for effective translational tools that bridge neurophysiological data with meaningful clinical outcomes. Temporal summation (TS) and conditioned pain modulation (CPM) are two promising tools yet to be widely utilized. These psychophysical measures capture the state of the ascending facilitation and the descending inhibition of nociceptive transmission, respectively. We review the basic concepts and current methodologies underlying these measures in clinical pain research, and illustrate their application to research on acupuncture analgesia. Finally, we highlight the strengths and limitations of these research methods and make recommendations on future directions. The appropriate addition of TS and CPM to our current research armamentarium will facilitate our efforts to elucidate the central analgesic mechanisms of acupuncture in clinical populations.

scholarly journals Central Nervous System Targets: Supraspinal Mechanisms of Analgesia

2020 ◽  
Vol 17 (3) ◽  
pp. 839-845 ◽  
Author(s):  
K. Bannister ◽  
A. H. Dickenson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pain Relief ◽  
Pain Modulation ◽  
Diverse Range ◽  
Nociceptive Transmission ◽  
Poor Treatment ◽  
Brain Circuitry ◽  
The Brain ◽  
Mechanisms Of Analgesia

Abstract While the acute sensation of pain is protective, signaling the presence of actual or potential bodily harm, its persistence is unpleasant. When pain becomes chronic, it has limited evolutionarily advantage. Despite the differing nature of acute and chronic pain, a common theme is that sufferers seek pain relief. The possibility to medicate pain types as varied as a toothache or postsurgical pain reflects the diverse range of mechanism(s) by which pain-relieving “analgesic” therapies may reduce, eliminate, or prevent pain. Systemic application of an analgesic able to cross the blood–brain barrier can result in pain modulation via interaction with targets at different sites in the central nervous system. A so-called supraspinal mechanism of action indicates manipulation of a brain-defined circuitry. Pre-clinical studies demonstrate that, according to the brain circuitry targeted, varying therapeutic pain-relieving effects may be observed that relate to an impact on, for example, sensory and/or affective qualities of pain. In many cases, this translates to the clinic. Regardless of the brain circuitry manipulated, modulation of brain processing often directly impacts multiple aspects of nociceptive transmission, including spinal neuronal signaling. Consideration of supraspinal mechanisms of analgesia and ensuing pain relief must take into account nonbrain-mediated effects; therefore, in this review, the supraspinally mediated analgesic actions of opioidergic, anti-convulsant, and anti-depressant drugs are discussed. The persistence of poor treatment outcomes and/or side effect profiles of currently used analgesics highlight the need for the development of novel therapeutics or more precise use of available agents. Fully uncovering the complex biology of nociception, as well as currently used analgesic mechanism(s) and site(s) of action, will expedite this process.

Author response for "Laminar distribution of cortical projection neurons to the pulvinar: A comparative study in cats and mice"

2020 ◽  
Author(s):  
Bruno Oliveira Ferreira de Souza ◽  
Éve‐Marie Frigon ◽  
Robert Tremblay‐Laliberté ◽  
Christian Casanova ◽  
Denis Boire
Keyword(s):  
Comparative Study ◽  
Author Response ◽  
Projection Neurons ◽  
Cortical Projection ◽  
Laminar Distribution
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