Optical resolution HPLC column packings carrying penicillin sulfoxide nucleus. Part II. Influence of the radical polymerization solvent on the optical resolution efficiency

1989 ◽  
Vol 28 (9-10) ◽  
pp. 509-510 ◽  
Author(s):  
Y. Saotome ◽  
T. Miyazawa ◽  
T. Endo
Keyword(s):  
Radical Polymerization ◽  
Optical Resolution ◽  
Hplc Column ◽  
Penicillin Sulfoxide ◽  
Column Packings

Synthesis of Axially Chiral 2,2’-Bisphosphobiarenes via a Nickel-Catalyzed Asymmetric Ullmann Coupling: General Access to Privileged Chiral Ligands without Optical Resolution

2020 ◽  
Author(s):  
Ziqing Zuo ◽  
Raphael Kim ◽  
Donald Watson
Keyword(s):  
Optical Resolution ◽  
Chiral Ligands ◽  
Chiral Auxiliaries ◽  
Axially Chiral ◽  
Ullmann Coupling

<div><p>We report an asymmetric Ullmann-type homocoupling of <i>ortho-</i>(iodo)arylphosphine oxides and <i>ortho</i>-(iodo)arylphosphonates that results in highly enantioenriched axially chiral bisphosphine oxides and bisphosphonates in good yields and excellent enantioselectivities. These products are readily converted to enantioenriched biaryl bisphosphines without need for chiral auxiliaries or optical resolution. This process provides a straightforward and practical route for the development of previously uninvestigated atroposelective biaryl bisphosphine ligands.</p></div>

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