Comparison of technetium 99m polyclonal human immunoglobulin and technetium 99m monoclonal antibodies for imaging chronic osteomyelitis

1991 ◽  
Vol 18 (6) ◽  
pp. 401-407 ◽  
Author(s):  
Joachim Sciuk ◽  
Wolfgang Brandau ◽  
Bernhard Vollet ◽  
Ralf Stücker ◽  
Rainer Erlemann ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Chronic Osteomyelitis ◽  
Human Immunoglobulin ◽  
Technetium 99M ◽  
Polyclonal Human Immunoglobulin

Technetium-99m-IgG polyclonal human immunoglobulin scintigraphy in the evaluation of sacroiliitis

1996 ◽  
Vol 23 (10) ◽  
pp. 1416-1416 ◽  
Author(s):  
W. D. Leslie ◽  
G. T. D. Thomson ◽  
J. O. Dupont ◽  
D. McDonald
Keyword(s):  
Human Immunoglobulin ◽  
Technetium 99M ◽  
Polyclonal Human Immunoglobulin

A novel method for the non-chromatographic purification of technetium-99m-labeled monoclonal antibodies: a study with B72.3 monoclonal antibody

1994 ◽  
Vol 21 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Howard S. Rosenzweig ◽  
Girish N. Ranadive ◽  
Troy Seskey ◽  
Michael W. Epperly ◽  
William D. Bloomer
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Chromatographic Purification ◽  
Technetium 99M ◽  
Novel Method

Functional role of carbohydrate residues in human immunoglobulin G and therapeutic monoclonal antibodies

2016 ◽  
Vol 81 (8) ◽  
pp. 835-857 ◽  
Author(s):  
Y. L. Dorokhov ◽  
E. V. Sheshukova ◽  
E. N. Kosobokova ◽  
A. V. Shindyapina ◽  
V. S. Kosorukov ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Immunoglobulin G ◽  
Functional Role ◽  
Human Immunoglobulin ◽  
Human Immunoglobulin G ◽  
Therapeutic Monoclonal Antibodies

Technetium-99m Labeled Monoclonal Antibodies in the Detection of Metastatic Melanoma

1989 ◽  
Vol 14 (8) ◽  
pp. 580-587 ◽  
Author(s):  
A N SERAFINI ◽  
J KOTLER ◽  
L FEUN ◽  
M DEWANJEE ◽  
D ROBINSON ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Metastatic Melanoma ◽  
Technetium 99M

scholarly journals Human Monoclonal Antibodies againstPseudomonas aeruginosa Lipopolysaccharide Derived from Transgenic Mice Containing Megabase Human Immunoglobulin Loci Are Opsonic and Protective against Fatal Pseudomonas Sepsis

2001 ◽  
Vol 69 (4) ◽  
pp. 2223-2229 ◽  
Author(s):  
Sonali Hemachandra ◽  
Kulwant Kamboj ◽  
Janna Copfer ◽  
Gerald Pier ◽  
Larry L. Green ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Transgenic Mice ◽  
Variable Region ◽  
Human Immunoglobulin ◽  
High Avidity ◽  
Genes Encoding ◽  
Antibody Titers ◽  
Multiple Donors ◽  
Human Polymorphonuclear Leukocytes ◽  
Variable Region Genes

ABSTRACT Pseudomonas aeruginosa is a significant human pathogen, and no vaccine is commercially available. Passive antibody prophylaxis using monoclonal antibodies (MAb) against protectiveP. aeruginosa epitopes is an alternative strategy for preventing P. aeruginosa infection, but mouse MAb are not suitable for use in humans. Polyclonal human antibodies from multiple donors have variable antibody titers, and human MAb are difficult to make. We used immunoglobulin-inactivated transgenic mice reconstituted with megabase-size human immunoglobulin loci to generate a human MAb against the polysaccharide (PS) portion of the lipopolysaccharide O side chain of a common pathogenic serogroup ofP. aeruginosa, 06ad. The anti-PS human immunoglobulin G2 MAb made from mice immunized with heat-killed P. aeruginosa was specific for serogroup 06ad pseudomonas. The MAb was highly opsonic for the uptake and killing of P. aeruginosa by human polymorphonuclear leukocytes in the presence of human complement. In addition, 25 μg of the MAb protected 100% of neutropenic mice from fatal P. aeruginosasepsis. DNA sequence analysis of the genes encoding the MAb revealed VH3 and Vκ2/A2 variable-region genes, similar to variable-region genes in humans immunized with bacterial PS and associated with high-avidity anti-PS antibodies. We conclude that human MAb to P. aeruginosa made in these transgenic mice are highly protective and that these mice mimic the antibody response seen in humans immunized with T-cell-independent antigens such as bacterial PS.

Technetium-99m human immunoglobulin scintigraphy in psoriatic arthropathy: first results

1994 ◽  
Vol 21 (4) ◽  
Author(s):  
Alfons Stoeger ◽  
Erich Mur ◽  
Doris Penz-Schneeweiss ◽  
Roy Moncayo ◽  
Clemens Decristoforo ◽  
...  
Keyword(s):  
Human Immunoglobulin ◽  
Psoriatic Arthropathy ◽  
Technetium 99M ◽  
First Results
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