Pyritinol facilitates the recovery of cortical cholinergic deficits caused by nucleus basalis lesions

1994 ◽  
Vol 7 (3) ◽  
pp. 195-209 ◽  
Author(s):  
A. Toledano ◽  
M. L. Bentura
Keyword(s):  
Nucleus Basalis ◽  
Nucleus Basalis Lesions

Nucleus basalis lesions: Implication of basoamygdaloid cholinergic pathways in memory

1995 ◽  
Vol 36 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Paul E. Mallet ◽  
Richard J. Beninger ◽  
Sheera N. Flesher ◽  
Khem Jhamandas ◽  
Roland J. Boegman
Keyword(s):  
Nucleus Basalis ◽  
Cholinergic Pathways ◽  
Nucleus Basalis Lesions

Nucleus basalis lesions decrease α-and α-bungarotoxins binding in rat cortex

Neuroreport ◽  
1991 ◽  
Vol 2 (4) ◽  
pp. 177-180 ◽  
Author(s):  
Kiminobu Sugaya ◽  
Martha Downen ◽  
Ezio Giacobini
Keyword(s):  
Nucleus Basalis ◽  
Rat Cortex ◽  
Nucleus Basalis Lesions

scholarly journals Cortical Hypometabolism and its Recovery following Nucleus Basalis Lesions in Baboons: A PET Study

1987 ◽  
Vol 7 (6) ◽  
pp. 812-817 ◽  
Author(s):  
Motohiro Kiyosawa ◽  
Sabina Pappata ◽  
Danielle Duverger ◽  
Danielle Riche ◽  
Henri Cambon ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Metabolic Rate ◽  
Nucleus Basalis ◽  
Emission Tomography ◽  
Metabolic Effects ◽  
Metabolic Depression ◽  
Cerebral Metabolic Rate ◽  
Positron Emission ◽  
Adaptive Mechanisms ◽  
Nucleus Basalis Lesions

The cerebral metabolic rate for glucose was measured serially with positron emission tomography and [18F]fluorodeoxyglucose in five baboons with stereotactic electrocoagulation of the left nucleus basalis of Meynert (NbM). Four days after lesion, a significant metabolic depression was present in the ipsilateral cerebral cortex, most marked in the frontotemporal region, and which recovered progressively within 6–13 weeks. These data demonstrate that adaptive mechanisms efficiently compensate for the cortical metabolic effects of NbM-lesion-induced cholinergic deafferentation. Moreover, unilateral NbM lesions also induced a transient reduction in contralateral cortical metabolic rate, the mechanisms of which are discussed. Explanation of these effects of cholinergic deafferentation in the primate could further our understanding of the metabolic deficits observed in dementia of the Alzheimer's type.

Nucleus basalis lesions fail to induce senile plaques in the rat

1990 ◽  
Vol 108 (1) ◽  
pp. 88-90 ◽  
Author(s):  
Leon J. Thal ◽  
Ronald J. Mandel ◽  
Robert D. Terry ◽  
Gyorgy Buzsaki ◽  
Fred H. Gage
Keyword(s):  
Senile Plaques ◽  
Nucleus Basalis ◽  
Nucleus Basalis Lesions

Effects of Nucleus Basalis Lesions on the Muscarinic and Nicotinic Modulation of [3H] Acetylcholine Release in the Rat Cerebral Cortex

1987 ◽  
Vol 49 (6) ◽  
pp. 1758-1762 ◽  
Author(s):  
Edwin M. Meyer ◽  
Gary W. Arendash ◽  
Jennifer H. Judkins ◽  
Lily Ying ◽  
Cathy Wade ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Acetylcholine Release ◽  
Nucleus Basalis ◽  
Rat Cerebral Cortex ◽  
Nucleus Basalis Lesions

Selective memory loss following nucleus basalis lesions: Long term behavioral recovery despite persistent cholinergic deficiencies

1985 ◽  
Vol 23 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Raymond T. Bartus ◽  
Charles Flicker ◽  
Reginald L. Dean ◽  
Michael Pontecorvo ◽  
Joanne C. Figueiredo ◽  
...  
Keyword(s):  
Memory Loss ◽  
Nucleus Basalis ◽  
Behavioral Recovery ◽  
Nucleus Basalis Lesions
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