Comparison of the effects of the 5-HT3 receptor antagonists WAY-100579 and ondansetron on spatial learning in the water maze in rats with excitotoxic lesions of the forebrain cholinergic projection system

1996 ◽  
Vol 125 (2) ◽  
pp. 146-161 ◽  
Author(s):  
H. Hodges ◽  
P. Sowinski ◽  
J. J. Turner ◽  
A. Fletcher
Keyword(s):  
Spatial Learning ◽  
Water Maze ◽  
Receptor Antagonists ◽  
Projection System ◽  
Cholinergic Projection

Effects of intra-accumbens NMDA and AMPA receptor antagonists on short-term spatial learning in the Morris water maze task

2007 ◽  
Vol 179 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Valentina Ferretti ◽  
Francesca Sargolini ◽  
Alberto Oliverio ◽  
Andrea Mele ◽  
Pascal Roullet
Keyword(s):  
Morris Water Maze ◽  
Ampa Receptor ◽  
Spatial Learning ◽  
Water Maze ◽  
Short Term ◽  
Receptor Antagonists ◽  
Maze Task ◽  
Water Maze Task ◽  
Morris Water Maze Task

Intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevents the H-89-induced spatial learning deficits in Morris water maze

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mahmoud Hashemzaei ◽  
Najmeh Baratzadeh ◽  
Iraj Sharamian ◽  
Sahar Fanoudi ◽  
Mehdi Sanati ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Spatial Memory ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Synergistic Effects ◽  
Deionized Water ◽  
Learning Deficits ◽  
Learning Impairments ◽  
Morris Water Maze Task

Abstract Objectives H-89 (a protein kinase AII [PKA II] inhibitor) impairs the spatial memory in the Morris water maze task in rats. In the present study, we aimed to study the protective effects of nicotine and O-acetyl-L-carnitine against H-89-induced spatial memory deficits. Methods Spatial memory impairment was induced by the bilateral intrahippocampal administration of 10 µM H-89 (dissolved in dimethyl sulfoxide, DMSO) to rats. The rats then received bilateral administrations of either nicotine (1 μg/μL, dissolved in saline) or O-acetyl-L-carnitine (100 μM/side, dissolved in deionized water) alone and in combination. Control groups received either saline, deionized water, or DMSO. Results The H-89-treated animals showed significant increases in the time and distance travelled to find hidden platforms, and there was also a significant decrease in the time spent in the target quadrant compared to DMSO-treated animals. Nicotine and O-acetyl-L-carnitine had no significant effects on H-89-induced spatial learning impairments alone, but the bilateral intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevented H-89-induced spatial learning deficits and increased the time spent in the target quadrant in comparison with H-89-treated animals. Conclusions Our results indicated the potential synergistic effects of nicotine and O-acetyl-L-carnitine in preventing protein kinase AII inhibitor (H-89)-induced spatial learning impairments.

scholarly journals Interactive involvement of hippocampal cAMP/PKA and cyclooxygenase-2 signaling pathways in spatial learning in the Morris water maze

2018 ◽  
Vol 56 (1) ◽  
pp. 58-66 ◽  
Author(s):  
Kaveh Tabrizian ◽  
Mahmoud Hashemzaei ◽  
Ali Akbar Nasiri ◽  
Sheyda Najafi ◽  
Fatemeh Amelinia ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Cyclooxygenase 2

Spatial learning of the water maze: Progression of brain circuits mapped with cytochrome oxidase histochemistry

2010 ◽  
Vol 93 (3) ◽  
pp. 362-371 ◽  
Author(s):  
N.M. Conejo ◽  
H. González-Pardo ◽  
F. Gonzalez-Lima ◽  
J.L. Arias
Keyword(s):  
Cytochrome Oxidase ◽  
Spatial Learning ◽  
Water Maze ◽  
Brain Circuits

A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze

2001 ◽  
Vol 41 (2) ◽  
pp. 210-219 ◽  
Author(s):  
M.L Woolley ◽  
J.C Bentley ◽  
A.J Sleight ◽  
C.A Marsden ◽  
K.C.F Fone
Keyword(s):  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze
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