Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

1996 ◽  
Vol 124 (1-2) ◽  
pp. 57-73 ◽  
Author(s):  
A. Schotte ◽  
P. F. M. Janssen ◽  
W. Gommeren ◽  
W. H. M. L. Luyten ◽  
P. Van Gompel ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Antipsychotic Drugs ◽  
In Vivo Receptor Binding

In vitro and in vivo receptor binding and deoxyglucose studies in rat brain with the potential antipsychotic Org 5222

1990 ◽  
Vol 183 (5) ◽  
pp. 1623
Author(s):  
J.A.D.M. Tonnaer ◽  
P. Room ◽  
W.M.J.B. Van Gemert ◽  
L.P.C. Delbressine ◽  
T. de Boer ◽  
...  
Keyword(s):  
Rat Brain ◽  
Receptor Binding ◽  
In Vivo Receptor Binding

scholarly journals In vitro and in vivo receptor binding profile of NRA0161 and NRA0562, novel atypical antipsychotics

1999 ◽  
Vol 79 ◽  
pp. 236
Author(s):  
Takeo Funakoshi ◽  
Shigeyuki Chaki ◽  
Ryoko Yoshikakwa ◽  
Shigeru Okuyama ◽  
Atsuro Nakazato ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Atypical Antipsychotics ◽  
Binding Profile ◽  
In Vivo Receptor Binding

In vitro or in vivo receptor binding: Where does the truth lie?

1986 ◽  
Vol 19 (4) ◽  
pp. 384-385 ◽  
Author(s):  
Joel S. Perlmutter ◽  
Marcus E. Raichle
Keyword(s):  
Receptor Binding ◽  
In Vivo Receptor Binding

A comparison of in vivo and in vitro neuroimaging of 5-HT1A receptor binding sites in the cat brain

2006 ◽  
Vol 31 (3) ◽  
pp. 226-232 ◽  
Author(s):  
Nicolas Aznavour ◽  
Latifa Rbah ◽  
Lucienne Léger ◽  
Colette Buda ◽  
Jean-Pierre Sastre ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Binding Sites ◽  
Cat Brain

scholarly journals Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1607 ◽  
Author(s):  
Manikowski ◽  
Jakobs ◽  
Jboor ◽  
Grobe
Keyword(s):  
Heparan Sulfate ◽  
Sonic Hedgehog ◽  
Receptor Binding ◽  
Feedback Loop ◽  
Cancer Cell Growth ◽  
Shh Signaling ◽  
Epithelial Cancers ◽  
And Function

Sonic hedgehog (Shh) signaling plays a tumor-promoting role in many epithelial cancers. Cancer cells produce soluble a Shh that signals to distant stromal cells that express the receptor Patched (Ptc). These receiving cells respond by producing other soluble factors that promote cancer cell growth, generating a positive feedback loop. To interfere with reinforced Shh signaling, we examined the potential of defined heparin and heparan sulfate (HS) polysaccharides to block Shh solubilization and Ptc receptor binding. We confirm in vitro and in vivo that proteolytic cleavage of the N-terminal Cardin–Weintraub (CW) amino acid motif is a prerequisite for Shh solubilization and function. Consistent with the established binding of soluble heparin or HS to the Shh CW target motif, both polysaccharides impaired proteolytic Shh processing and release from source cells. We also show that HS and heparin bind to, and block, another set of basic amino acids required for unimpaired Shh binding to Ptc receptors on receiving cells. Both modes of Shh activity downregulation depend more on HS size and overall charge than on specific HS sulfation modifications. We conclude that heparin oligosaccharide interference in the physiological roles of HS in Shh release and reception may be used to expand the field of investigation to pharmaceutical intervention of tumor-promoting Shh functions.

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