Time course of the effects of adrenalectomy and corticosterone replacement on 5-HT1A receptors and 5-HT uptake sites in the hippocampus and dorsal raphe nucleus of the rat brain: an autoradiographic analysis

1994 ◽  
Vol 113 (3-4) ◽  
pp. 481-486 ◽  
Author(s):  
Shanaz M. Tejani-Butt ◽  
Daniel M. Labow
Keyword(s):  
Rat Brain ◽  
Time Course ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Uptake Sites ◽  
Autoradiographic Analysis ◽  
5 Ht Uptake ◽  
Dorsal Raphé

Effects of Acute or Chronic Administration of Anti-Migraine Drugs Sumatriptan and Zolmitriptan on Serotonin Synthesis in the Rat Brain

Cephalalgia ◽  
2004 ◽  
Vol 24 (1) ◽  
pp. 2-11 ◽  
Author(s):  
CF Dobson ◽  
Y Tohyama ◽  
M Diksic ◽  
E Hamel
Keyword(s):  
Rat Brain ◽  
Dorsal Raphe Nucleus ◽  
Chronic Administration ◽  
Brain Regions ◽  
Dorsal Raphe ◽  
Serotonin Release ◽  
Raphe Nucleus ◽  
Synthesis Rate ◽  
Regional Effects ◽  
Dorsal Raphé

Triptans are 5-HT1 receptor agonists used as anti-migraine drugs. They act primarily on meningeal blood vessels and on trigeminovascular afferents, but they may also exert central effects. We studied the regional effects of acute and chronic treatment with sumatriptan or zolmitriptan on the rate of serotonin (5-HT) synthesis in the rat brain, using the α-14C-methyl-L-tryptophan quantitative autoradiographic method. Sumatriptan at low (300 μg/kg, s.c.) and high (1 mg/kg) doses, as well as zolmitriptan (100 μg/kg), acutely decreased (15-40%, P < 0.05-0.001) 5-HT synthetic rate in many brain regions, including the dorsal raphe nucleus. Chronically, sumatriptan (21 days, approximately 300 μg/kg per day via osmotic minipumps) induced significant increases in the 5-HT synthesis rate in many projection areas but had no effect in the dorsal raphe nucleus. The acute effects on 5-HT synthesis rate would be compatible with activation of 5-HT1 autoreceptors that inhibit serotonin release. In contrast, the increased 5-HT synthesis rate observed after chronic sumatriptan might possibly result from a down-regulation/desensitization of 5-HT1 receptors and/or unmasking of excitatory triptan-sensitive 5-HT receptors. Overall, the present findings indicate that not only zolmitriptan but also sumatriptan affect brain serotonergic neurotransmission.

scholarly journals Control of serotonergic neurons in rat brain by dopaminergic receptors outside the dorsal raphe nucleus

2001 ◽  
Vol 77 (3) ◽  
pp. 762-775 ◽  
Author(s):  
Raúl Martín-Ruiz ◽  
Luisa Ugedo ◽  
María A. Honrubia ◽  
Guadalupe Mengod ◽  
Francesc Artigas
Keyword(s):  
Rat Brain ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dopaminergic Receptors ◽  
Serotonergic Neurons ◽  
Dorsal Raphé
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