Effects of in-vitro neutralization on the composition of the nondialyzable components of human gastric juice

1967 ◽  
Vol 12 (4) ◽  
pp. 389-395 ◽  
Author(s):  
Jack D. Welsh ◽  
Clifford D. Wallace ◽  
Anthony Walker ◽  
Lois Russell
Keyword(s):  
Gastric Juice ◽  
Human Gastric Juice

Some Observations on the Effect of Digestive Juices on Scolices ofEchinococcus granulosus(Batsch).

1936 ◽  
Vol 14 (1) ◽  
pp. 21-40 ◽  
Author(s):  
D. A. Berberian
Keyword(s):  
Gastric Juice ◽  
Intestinal Tract ◽  
Time Intervals ◽  
Human Gastric Juice ◽  
Rate Of Development ◽  
Single Cyst ◽  
Intestinal Juice ◽  
Definite Time

Experimentsin vivoandin vitroare reported on the action of digestive juices of various animals on the scolices ofE. granulosus. Inin vitrostudies, scolices ofE. granulosuswere placed in the digestive juices of different animals, incubated at 37°C., and the digestive action of the fluids was studied by examining portions of the material under the microscope.In vivoexperiments were carried out on kittens, rats and rabbits. These animals were fed large quantities of scolices of hydatid cyst membranes and they were killed at definite time intervals and their intestinal tract was carefully examined for scolices.Gastric juice of rats, dogs, cats, sheep and cattle did not digest scolices. The action of the gastric juice of rabbits begins late and proceeds slowly. Human gastric juice causes incomplete digestion and acts only on the evaginated scolices.The intestinal juices of man, rats, rabbits, sheep and cattle are able to digest scolices completely, whereas the intestinal juice of dogs and cats is inactive. In spite of the fact that cat intestinal juice is inactive, kittens are found to be slightly susceptible. Since they suffer only relatively light infestation and the rate of development is retarded, we would classify the cat as an “abnormal” host toE. granulosus.Time of evagination of scolices from a single cyst or from cysts from different animals is variable. Some scolices evaginate readily, others more slowly and still others fail to evaginate completely.

Comparative nitrosation of etintidine and cimetidine

1983 ◽  
Vol 61 (8) ◽  
pp. 1771-1777 ◽  
Author(s):  
Thomas A. Montzka ◽  
Peter F. Juby ◽  
John D. Matiskella ◽  
Henry M. Holava ◽  
R. R. Crenshaw
Keyword(s):  
Receptor Antagonist ◽  
Gastric Juice ◽  
Nitrite Concentration ◽  
Human Gastric Juice

Etintidine (4), a new histamine H2-receptor antagonist, was compared with cimetidine (1) for susceptibility to in vitro nitrosation at pH 1 and pH 3. Each agent formed two mono-N-nitrosoguanidine derivatives: N-cyano-N′-{2-[(5-methyl-1H-imidazol-4-yl)methylthio]ethyl}-N″-nitroso-N″-(2-propynyl)guanidine (5) and N-cyano-N′-{2-[5-methyl-1H-imidazol-4-yl)methylthio]ethyl}- N′-nitroso-N″-(2-propynyl)guanidine (6) from etintidine and N-cyano-N′-methyl-N″-{2-[(5-methyl-1H-imidazol-4-yl)methylthio]ethyl}- N′-nitrosoguanidinc (2) and N-cyano-N′-methyl-N"-{2-[(5-methyl-1H-imidazol-4-yl)methyl-thio]ethyl}-N′-nitrosoguanidine (11) from cimetidine. The N-nitroso derivative 5 from etintidine cyclized to 2-cyanoimino-3-{2-((5-methyl-1H-imidazol-4-yl)methylthio]ethyl}-N″-methylene-1-nitroso-imidazoline (7) at neutral or basic pH's. Both agents were nitrosated less at pH 3 than at pH 1, and at both pH's nitrosation of etintidine was considerably less than that of cimetidine. At pH 1, with a nitrite concentration about 150–500 times that expected in fasting human gastric juice, formation of 5 and 6 from etintidine was barely detectable (each < 0.5%). Comments are made on the standard WHO conditions for investigating nitrosation of drugs.

In vitro sensitivity of probiotics to human gastric juice

2006 ◽  
Vol 38 ◽  
pp. S134 ◽  
Author(s):  
M. Del Piano ◽  
M. Ballarè ◽  
A. Anderloni ◽  
S. Carmagnola ◽  
F. Montino ◽  
...  
Keyword(s):  
Gastric Juice ◽  
Human Gastric Juice ◽  
In Vitro Sensitivity

Kinetics of chlorambucil in vitro: effects of fluid matrix, human gastric juice, plasma proteins and red cells

1997 ◽  
Vol 103 (3) ◽  
pp. 187-198 ◽  
Author(s):  
K. Löf ◽  
J. Hovinen ◽  
P. Reinikainen ◽  
L.M. Vilpo ◽  
E. Seppälä ◽  
...  
Keyword(s):  
Gastric Juice ◽  
Plasma Proteins ◽  
Red Cells ◽  
Human Gastric Juice ◽  
In Vitro Effects ◽  
Kinetics Of

Influence of human gastric juice on oxidation of marine lipids – in vitro study

2013 ◽  
Vol 141 (4) ◽  
pp. 3859-3871 ◽  
Author(s):  
Vera Kristinova ◽  
Ivar Storrø ◽  
Turid Rustad
Keyword(s):  
Gastric Juice ◽  
In Vitro Study ◽  
Vitro Study ◽  
Human Gastric Juice ◽  
Marine Lipids

scholarly journals STUDIES OF STERIGMATOCYSTIN (ST) PRODUCED BY ASPERGILLUS VERSICOLOR IN HUMAN GASTRIC JUICE IN VITRO

1988 ◽  
Vol 1988 (1Supplement) ◽  
pp. 127-128 ◽  
Author(s):  
He-ling Sun ◽  
Dian-sheng Wang ◽  
Ke-qiang Wang ◽  
He-jun Hong
Keyword(s):  
Gastric Juice ◽  
Aspergillus Versicolor ◽  
Human Gastric Juice
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