Elimination ofTheileria buffeli infections from cattle by concurrent treatment with primaquine phosphate and halofuginone lactate

1990 ◽  
Vol 22 (2) ◽  
pp. 109-115 ◽  
Author(s):  
N. P. Stewart ◽  
A. J. de Vos ◽  
I. Shiels
Keyword(s):  
Concurrent Treatment ◽  
Primaquine Phosphate

Elimination ofTheileria buffeli infections from cattle by concurrent treatment with buparvaquone and primaquine phosphate

1990 ◽  
Vol 22 (2) ◽  
pp. 116-122 ◽  
Author(s):  
N. P. Stewart ◽  
A. J. de Vos ◽  
N. McHardy ◽  
N. F. Standfast
Keyword(s):  
Concurrent Treatment ◽  
Primaquine Phosphate

Concurrent Treatment of Suicidal, Depressed Adolescents and a Depressed Parent

2010 ◽  
Author(s):  
Anthony Spirito ◽  
Ivan Miller ◽  
Jennifer Wolff ◽  
Caron Zlotnick ◽  
Rupa Puri ◽  
...  
Keyword(s):  
Concurrent Treatment ◽  
Depressed Parent

Evaluation of efficacy of Aloe vera (L.) Burm. f. gel solution in methylcellulose-induced ocular hypertension in New Zealand white rabbits

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Jhanvi J. Vaghela ◽  
Manish J. Barvaliya ◽  
Sugnesh J. Parmar ◽  
Chandrabhanu R. Tripathi
Keyword(s):  
Disease Control ◽  
Ocular Hypertension ◽  
Aloe Vera ◽  
Group Iv ◽  
Control Group ◽  
Group Vi ◽  
Concurrent Treatment ◽  
Maximum Reduction ◽  
New Zealand White Rabbits ◽  
Time Point

AbstractObjectivesThe present study aimed to evaluate the efficacy of Aloe vera in the methylcellulose-induced ocular hypertension model.MethodsFifty-six rabbits were randomly divided into seven groups. Intraocular pressure (IOP) was raised by anterior chamber injection of 2% methylcellulose in all the groups except the normal control group. Disease control animals were treated with sterile water and active control with topical 0.5% timolol 12 hourly; 6 and 12% A. vera gel topical solutions 8 hourly were given in group IV and V, respectively; 6 and 12% A. vera gel solutions along with timolol were given in group VI and VII animals, respectively. Mean IOP values and percentage of reduction in IOP were compared at 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 12 h, 24 h, 36 h, and 48 h.ResultsA. vera gel solutions (6 and 12%) showed a significant reduction in mean IOP from 4 to 2 h time points, respectively, whereas, A. vera gel solutions (6 and 12%) + timolol showed significant less mean IOP from a 30 min time point as compared with disease control. A. vera gel solutions (6 and 12%) showed 8.6 and 10.4% more reduction in IOP, respectively (66.8 ± 4.9% and 68.6 ± 5.4% vs. 58.2 ± 2.3%; p > 0.05), whereas 6 and 12% A. vera gel solutions along with timolol showed 14.5 and 16.2% more reduction in IOP, respectively (72.7 ± 4.7% and 74.4 ± 4.1% vs. 58.2 ± 2.3%; p < 0.05), than disease control group at 48 h.ConclusionsSix and twelve percent A. vera gel solutions reduced the IOP effectively. Concurrent treatment with 12% A. vera gel and timolol produced the maximum reduction in IOP.

scholarly journals Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168286 ◽  
Author(s):  
So Youn Park ◽  
Hae Young Kim ◽  
Hee Jeong Park ◽  
Hwa Kyoung Shin ◽  
Ki Whan Hong ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Concurrent Treatment ◽  
Amyloid Accumulation ◽  
Β Amyloid

scholarly journals Erratum to: Safety of concurrent treatment of cats with fluralaner and emodepsid-praziquantel

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Feli M. Walther ◽  
Mark J. Allan ◽  
Rainer K. A. Roepke
Keyword(s):  
Concurrent Treatment

scholarly journals Spinal Tolerance and Dependence: Some Observations on the Role of SpinalN-Methyl-D-Aspartate Receptors and Phosphorylation in the Loss of Opioid Analgesic Responses

2000 ◽  
Vol 5 (1) ◽  
pp. 33-39
Author(s):  
Tony L Yaksh ◽  
Xiao-Ying Hua
Keyword(s):  
Nmda Receptor ◽  
Opioid Analgesic ◽  
Dose Effect ◽  
Concurrent Treatment ◽  
Analgesic Effects ◽  
Delta Opioids ◽  
Probable Role ◽  
Pkc Isozymes ◽  
The Right

The continuous delivery of opiates can lead to a reduction in analgesic effects. In humans, as in other animals, some component of this change in sensitivity seems likely to have a strong pharmacodynamic component. Such loss of effect, deemed to be tolerance in the present article, can be readily demonstrated in animals with repeated bolus and continuous intrathecal infusion of mu and delta opioids and alpha-2 adrenergic agonists. Research has shown that this loss of effect can be diminished by concurrent treatment withN-methyl-D-aspartate (NMDA) receptor antagonists and by the suppression of the activity of spinal protein kinase C (PKC). This suggests in part the probable role of PKC-mediated phosphorylation in the right shift in the dose-effect curves observed with continuous opiate or adrenergic exposure. Importantly, this right shift is seen to occur in parallel with an increase in the phosphorylating activity in the dorsal horn and in the expression of several PKC isozymes. The target of this phosphorylation is not certain. Phosphorylation of the NMDA receptor enhances its functionality, while phosphorylation of the opioid receptor or associated channels seems to diminish their activity or to enhance internalization. While the focus is on several specific components, the accumulating data emphasize the biological complexity of these changes in spinal drug reactivity.

The Efficacy of Concurrent or Sequential Intravenous and Intratympanic Steroid for Idiopathic Sudden Sensorineural Hearing Loss

2018 ◽  
Vol 23 (5) ◽  
pp. 277-284 ◽  
Author(s):  
Chia-Huei Chu ◽  
Shiau-Ru Chiou ◽  
Mao-Che Wang ◽  
An-Suey Shiao ◽  
Tzong-Yang Tu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sequential Therapy ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Concurrent Treatment ◽  
Treatment Groups ◽  
Sequential Group ◽  
The Difference ◽  
Hearing Outcomes

Objective: The purpose of this retrospective study was to investigate the difference in treatment outcomes for patients with idiopathic sudden sensorineural hearing loss (SSNHL) undergoing concurrent or sequential intravenous (IV) and intratympanic (IT) steroid therapies. Methods: Patients with idiopathic SSNHL admitted to Taipei Veterans Hospital from August 2011 to August 2012 were enrolled. Patients were treated with both IV dexamethasone 5 mg b.i.d. for 5 days, then tapered over 6 days, and IT injections of dexamethasone 5 mg daily. The administration of IV and IT steroids was given either concurrently or sequentially (IV steroid was administered from days 1–5 followed by IT steroid treatment starting on day 4 or day 5). The hearing outcomes of the concurrent and sequential groups were analyzed. Results: Overall, after ≥2 months following treatment, across frequencies ranging from 250 to 8,000 Hz and pure-tone average (PTA) assessments, hearing improvements were similar between treatment groups, except at the frequencies of 4,000 and 8,000 Hz where the concurrent treatment group had greater hearing gain than the sequential group (4,000 Hz: 30.68 ± 28.96 vs. 14.52 ± 24.06 dB, respectively, p = 0.042; 8,000 Hz: 22.62 ± 23.59 vs. 7.67 ± 21 dB, p = 0.030). Across frequencies and PTA assessments, a similar percentage of patients had ≥20-dB gains in hearing compared with patients treated sequentially, except at 8,000 Hz where a greater percentage of patients in the concurrent group (57.1%) than the sequential group (23.3%) (p = 0.014) had ≥20-dB hearing gains. Conclusion: The findings suggest that both concurrent and sequential treatment improve hearing in patients with idiopathic SSNHL, and that concurrent treatment may show greater benefit than sequential therapy, particularly at high frequencies.

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