Retrobulbar optic neuritis after pamidronate administration in a patient with a history of cutaneous porphyria

1997 ◽  
Vol 16 (1) ◽  
pp. 93-95 ◽  
Author(s):  
J. M. Des Grottes ◽  
M. Schrooyen ◽  
J. C. Dumon ◽  
J. J. Body
Keyword(s):  
Optic Neuritis ◽  
History Of ◽  
Retrobulbar Optic Neuritis

scholarly journals Serum neurofilament levels reflect outer retinal layer changes in multiple sclerosis

2021 ◽  
Vol 14 ◽  
pp. 175628642110034
Author(s):  
Caspar B. Seitz ◽  
Falk Steffen ◽  
Muthuraman Muthuraman ◽  
Timo Uphaus ◽  
Julia Krämer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Previous History ◽  
Supervised Machine Learning ◽  
Support Vector ◽  
Retinal Layer ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Retinal Layers ◽  
History Of

Background: Serum neurofilament light chain (sNfL) and distinct intra-retinal layers are both promising biomarkers of neuro-axonal injury in multiple sclerosis (MS). We aimed to unravel the association of both markers in early MS, having identified that neurofilament has a distinct immunohistochemical expression pattern among intra-retinal layers. Methods: Three-dimensional (3D) spectral domain macular optical coherence tomography scans and sNfL levels were investigated in 156 early MS patients (female/male: 109/47, mean age: 33.3 ± 9.5 years, mean disease duration: 2.0 ± 3.3 years). Out of the whole cohort, 110 patients had no history of optic neuritis (NHON) and 46 patients had a previous history of optic neuritis (HON). In addition, a subgroup of patients ( n = 38) was studied longitudinally over 2 years. Support vector machine analysis was applied to test a regression model for significant changes. Results: In our cohort, HON patients had a thinner outer plexiform layer (OPL) volume compared to NHON patients ( B = −0.016, SE = 0.006, p = 0.013). Higher sNfL levels were significantly associated with thinner OPL volumes in HON patients ( B = −6.734, SE = 2.514, p = 0.011). This finding was corroborated in the longitudinal subanalysis by the association of higher sNfL levels with OPL atrophy ( B = 5.974, SE = 2.420, p = 0.019). sNfL levels were 75.7% accurate at predicting OPL volume in the supervised machine learning. Conclusions: In summary, sNfL levels were a good predictor of future outer retinal thinning in MS. Changes within the neurofilament-rich OPL could be considered as an additional retinal marker linked to MS neurodegeneration.

scholarly journals Retrobulbar optic neuritis after Hepatitis A vaccination in a HIV-infected patient

Eye ◽  
2009 ◽  
Vol 23 (12) ◽  
pp. 2267-2271 ◽  
Author(s):  
E H Z Huang ◽  
S A Lim ◽  
P L Lim ◽  
Y S Leo
Keyword(s):  
Optic Neuritis ◽  
Infected Patient ◽  
Hepatitis A ◽  
Retrobulbar Optic Neuritis

Retrobulbar optic neuritis due to diseases of the posterior sinuses

1927 ◽  
Vol 23 (9) ◽  
pp. 973-973
Author(s):  
N. A. Khristianov
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Circulatory System ◽  
Nerve Lesions ◽  
Retrobulbar Optic Neuritis ◽  
Anatomical Connection

Close anatomical connection between the optic nerve and the posterior nasal appendages and the commonality of their circulatory system explain optic nerve lesions in purulent and catarrhal processes in the posterior sinuses. N.A. Khristianov describes a case of left-sided retrobulbar optic neuritis cured by opening the middle and posterior lattices of the same side, affected by chronic catarrh.

scholarly journals Demographic pattern, clinical profile and visual outcome of patients with optic neuritis in a tertiary level eye care center of eastern Nepal

2014 ◽  
Vol 11 (3) ◽  
pp. 250-253
Author(s):  
BG Shrestha ◽  
M Sharma ◽  
P Lavaju ◽  
SM Pokharel ◽  
N Agrawal ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Optic Neuritis ◽  
Care Center ◽  
Visual Outcome ◽  
Clinical Profile ◽  
Response To Treatment ◽  
Female Ratio ◽  
History Of ◽  
Intravenous Steroids ◽  
Time Of Presentation

Introduction: Optic neuritis is one of the common causes of sudden visual impairment. Early diagnosis and treatment with intravenous steroids can hasten visual recovery. Objective: To analyze the demographic pattern, clinical profile, and response to treatment with pulse methylprednisolone in patients presenting with optic neuritis. Methods: A hospital based retrospective analysis of records of patients with optic neuritis presenting at BPKIHS between April 2010 to February 2012 was carried out. Demographic pattern, clinical profile and visual outcome at the time of presentation and discharge were recorded. Results: Thirty-five patients (44 eyes) presented with optic neuritis. A total of 33 eyes (75%) had papillitis and 11 eyes (25%) had retrobulbar optic neuritis. Male to female ratio was 2.18:1. The mean age at presentation was 31.20 ± 17.07 years. Diminution of vision was the commonest mode of presentation. Bilateral involvement was seen in 9 patients (25.71%). The 38 eyes (86.36%) had abnormal pupillary reaction. Eight patients (22.85%) had preceeding history of trauma, 1 (2.85%) had ethmoidal sinusitis and 1 (2.85%) otitis media. At the time of discharge 32 eyes (72.7%) showed recovery in visual acuity after pulse I.V. methylprednisolone therapy. Duration at presentation, visual acuity at presentation and diagnosis did not affect the final visual outcome (p=0.486, p=0.162 and p=0.122 respectively). Conclusion: Majority of patients presented with papillitis of idiopathic origin. Most of the cases were unilateral. Most patients with visual acuity of at least perception of light or better at the time of presentation improved after pulse I.V. methylprednisolone therapy. DOI: http://dx.doi.org/10.3126/hren.v11i3.9641 Health Renaissance 2013;11(3):250-253

scholarly journals MS optic neuritis-induced long-term structural changes within the visual pathway

2020 ◽  
Vol 7 (2) ◽  
pp. e665 ◽  
Author(s):  
Marc Pawlitzki ◽  
Marc Horbrügger ◽  
Kristian Loewe ◽  
Jörn Kaufmann ◽  
Roland Opfer ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Structural Damage ◽  
Structural Changes ◽  
Visual Pathway ◽  
System Structure ◽  
Pattern Reversal ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
History Of

BackgroundThe visual pathway is commonly involved in multiple sclerosis (MS), even in its early stages, including clinical episodes of optic neuritis (ON). The long-term structural damage within the visual compartment in patients with ON, however, is yet to be elucidated.ObjectiveOur aim was to characterize visual system structure abnormalities using MRI along with optical coherence tomography (OCT) and pattern-reversal visual evoked potentials (VEPs) depending on a single history of ON.MethodsTwenty-eight patients with clinically definitive MS, either with a history of a single ON (HON) or without such history and normal VEP findings (NON), were included. OCT measures comprised OCT-derived peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell/inner plexiform layer (GCIPL) thickness. Cortical and global gray and white matter, thalamic, and T2 lesion volumes were assessed using structural MRI. Diffusion-weighted MRI-derived measures included fractional anisotropy (FA), mean (MD), radial (RD), and axial (AD) diffusivity within the optic radiation (OR).ResultsMean (SD) duration after ON was 8.3 (3.7) years. Compared with the NON group, HON patients showed significant RNFL (p = 0.01) and GCIPL thinning (p = 0.002). OR FA (p = 0.014), MD (p = 0.005), RD (p = 0.007), and AD (p = 0.004) were altered compared with NON. Global gray and white as well as other regional gray matter structures did not differ between the 2 groups.ConclusionA single history of ON induces long-term structural damage within the retina and OR suggestive of both retrograde and anterograde neuroaxonal degeneration.

Retrobulbar optic neuritis in a two-year-old boy

1990 ◽  
Vol 12 (6) ◽  
pp. 795-797 ◽  
Author(s):  
Kousaku Matsubara ◽  
Kei Suzuki ◽  
Masayuki Itoh ◽  
Shigeru Ohta ◽  
Yukinori Maeoka ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Retrobulbar Optic Neuritis
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