Polyamines, diamine oxidase, and ornithine decarboxylase activity in colorectal cancer and in normal surrounding mucosa

1993 ◽  
Vol 36 (7) ◽  
pp. 662-667 ◽  
Author(s):  
Michele Linsalata ◽  
Francesco Russo ◽  
Aldo Cavallini ◽  
Pasquale Berloco ◽  
Alfredo Di Leo
Keyword(s):  
Colorectal Cancer ◽  
Ornithine Decarboxylase ◽  
Diamine Oxidase ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity

scholarly journals ORNITHINE DECARBOXYLASE ACTIVITY AS A PROGNOSTIC MARKER FOR COLORECTAL CANCER

2007 ◽  
Vol 53 (1) ◽  
pp. 1-9 ◽  
Author(s):  
YUTAKA HOSHINO ◽  
SHINYA TERASHIMA ◽  
YASUSHI TERANISHI ◽  
MASANORI TERASHIMA ◽  
MICHIHIKO KOGURE ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Marker ◽  
Ornithine Decarboxylase ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity

scholarly journals Effects of aliphatic diamines on rat liver ornithine decarboxylase activity

1978 ◽  
Vol 170 (3) ◽  
pp. 651-660 ◽  
Author(s):  
A E Pegg ◽  
C Conover ◽  
A Wrona
Keyword(s):  
Ornithine Decarboxylase ◽  
Rat Liver ◽  
Diamine Oxidase ◽  
Normal Values ◽  
Intraperitoneal Administration ◽  
Oxidase Inhibitor ◽  
Decarboxylase Activity ◽  
Rapid Loss ◽  
Polyamine Synthesis ◽  
Ornithine Decarboxylase Activity

Rat liver ornithine decarboxylase activity was decreased by administration of putrescine (1,4-diaminobutane) or other diamines, including 1,3-diaminopropane, 1,5-diaminopentane and 1,6-diaminohexane. This effect was seen in control rats and in rats in which hepatic ornithine decarboxylase activity had been increased by administration of growth hormone (somatotropin) or thioacetamide. Loss of activity was not dependent on the conversion of putrescine into polyamines and was short-lived. Within 6h after intraperitoneal administration of 0.8 mmol/kg body wt., ornithine decarboxylase activity had returned to normal values. This return correlated with the rapid loss of the diamines from the liver, and the decrease in activity could be slightly prolonged by treatment with aminoguanidine, a diamine oxidase inhibitor. A decrease in ornithine decarboxylase activity by these diamines was accompanied by the accumulation in the liver of a nondiffusible inhibitor that decreased the activity of a purified ornithine decarboxylase preparation. The possibility that administration of non-physiological diamines that are not converted into polyamines might be useful for the inhibition of polyamine synthesis is discussed.

Ornithine Decarboxylase Activity in Cultured Endothelial Cells Stimulated by Serum, Thrombin and Serotonin

1978 ◽  
Vol 39 (02) ◽  
pp. 496-503 ◽  
Author(s):  
P A D’Amore ◽  
H B Hechtman ◽  
D Shepro
Keyword(s):  
Endothelial Cells ◽  
Ornithine Decarboxylase ◽  
Decarboxylase Activity ◽  
Aortic Endothelial Cells ◽  
Ornithine Decarboxylase Activity ◽  
Rate Limiting Step ◽  
Bovine Aortic Endothelial Cells ◽  
Limiting Step ◽  
Rate Limiting ◽  
Serum Serotonin

SummaryOrnithine decarboxylase (ODC) activity, the rate-limiting step in the synthesis of polyamines, can be demonstrated in cultured, bovine, aortic endothelial cells (EC). Serum, serotonin and thrombin produce a rise in ODC activity. The serotonin-induced ODC activity is significantly blocked by imipramine (10-5 M) or Lilly 11 0140 (10-6M). Preincubation of EC with these blockers together almost completely depresses the 5-HT-stimulated ODC activity. These observations suggest a manner by which platelets may maintain EC structural and metabolic soundness.

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