Computed normal values for peak acid output based on age, sex and body weight

1970 ◽  
Vol 15 (9) ◽  
pp. 783-789 ◽  
Author(s):  
Alden H. Blackman ◽  
Donald L. Lambert ◽  
Walter R. Thayer ◽  
Horace F. Martin
Keyword(s):  
Body Weight ◽  
Normal Values ◽  
Acid Output ◽  
Peak Acid Output

A Study of the Acid Dose-Response Curve to Small Doses of Pentagastrin in Duodenal Ulcer Patients

1972 ◽  
Vol 43 (2) ◽  
pp. 181-191
Author(s):  
J. B. Elder ◽  
G. Gillespie ◽  
E. H. G. Campbell ◽  
I. E. Gillespie ◽  
G. P. Crean ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Body Weight ◽  
Dose Response ◽  
Response Curve ◽  
Acid Output ◽  
Twilight Zone ◽  
Response Curves ◽  
Small Doses ◽  
Threshold Doses ◽  
Body Weight Dose

1. The acid secretory responses to a range of small doses of pentagastrin in 0·15 m-NaCl have been studied in thirty-one preoperative duodenal ulcer subjects. Acid output increased significantly above basal values when a dose of 0·064 μg h−1 kg−1 was given. 2. Control observations in sixteen duodenal ulcer patients using the saline solvent alone at identical rates of infusion showed no significant increase in acid output. 3. From the dose-response curves sub-threshold and threshold doses of pentapeptide are suggested for duodenal ulcer patients before truncal vagotomy. 4. Considerable variation in acid response was noted between patients given the same body-weight dose of pentapeptide. The results suggest that a ‘twilight zone’ of stimulation exists between the dose of pentagastrin by which few patients are stimulated and the dose by which the majority are stimulated. This may reflect some variation in the sensitivity to stimulation by pentagastrin from one patient to another.

Effect of thiamine deficiency on canine gastric secretion of acid

1959 ◽  
Vol 197 (2) ◽  
pp. 253-256 ◽  
Author(s):  
Marjorie K. Lavers ◽  
Patricia A. Stefanik ◽  
Charles F. Code
Keyword(s):  
Body Weight ◽  
Hydrochloric Acid ◽  
Gastric Mucosa ◽  
Gastric Secretion ◽  
Thiamine Deficiency ◽  
Acid Output ◽  
Nervous Stimulation ◽  
Deficiency State ◽  
Bethanechol Chloride ◽  
Secretory Capacity

A study was undertaken to determine the effect of thiamine deficiency on the hydrochloric acid output of vagally denervated gastric pouches (Heidenhain-type) and vagally innervated gastric pouches (Pavlov-type) in dogs. Responses of both types of pouches to injection of 0.05 mg of histamine/kg of body weight and the maximal secretory capacity of both types after histamine were unaltered during the deficiency state. A degree of thiamine deficiency sufficient to produce anorexia and neuritis was without effect on the secretory response of canine gastric mucosa to histamine. The hydrochloric acid output of vagally innervated pouches during nervous stimulation caused by insulin-induced hypoglycemia was drastically reduced as soon as thiamine deficiency developed, while the response to bethanechol chloride was little, if at all, affected. It is concluded that the vagal secretory mechanism participates in the general neural failure of thiamine deficiency and that this failure most likely is in the neurons of the vagal nuclei.

scholarly journals One or Two Hours of Peak Acid Output

1980 ◽  
Vol 78 (6) ◽  
pp. 1655-1656
Author(s):  
James L. Achord ◽  
Sharon Wells
Keyword(s):  
Acid Output ◽  
Peak Acid Output

The fluctuation of tear production in the dog

1998 ◽  
Vol 34 (1) ◽  
pp. 79-83 ◽  
Author(s):  
SL Berger ◽  
VL King
Keyword(s):  
Body Weight ◽  
Normal Values ◽  
Weekly Basis ◽  
Tear Production ◽  
Schirmer Tear Test ◽  
Healthy Dogs

The fluctuation and variation in canine tear production were established by evaluating the results of daily Schirmer tear test I (STT I) and weekly STT I and Schirmer tear test II (STT II) conducted on healthy dogs. The objectives of the study were to determine the fluctuation in STT values in dogs and its significance on both a daily and weekly basis; to determine the magnitude of the measured differences; and to identify any factors that might influence the fluctuation in STT values or variations of normal values between different dogs. The results of the study indicate that fluctuations in the STT values occur on both a daily and weekly basis. The fluctuations were only biologically significant on a week-to-week basis. There are significant differences between STT I and STT II values in dogs. The results also indicate that weight has a significant effect on STT values, with higher values measured in dogs of increasing body weight.

scholarly journals Studies of basal and peak acid output with an augmented histamine test

Gut ◽  
1963 ◽  
Vol 4 (2) ◽  
pp. 136-144 ◽  
Author(s):  
J. H. Baron
Keyword(s):  
Acid Output ◽  
Peak Acid Output

scholarly journals Timing of Peak Acid Output after Pentagastrin

1969 ◽  
Vol 56 (3) ◽  
pp. 641-643 ◽  
Author(s):  
J.H. Baron
Keyword(s):  
Acid Output ◽  
Peak Acid Output

Measurement of Blood Cortisol and Acid Output in Patients with Duodenal Ulceration and Normal Subjects During Insulin Hypoglycaemia

1985 ◽  
Vol 69 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Anna C. Athow ◽  
Anna T. Sewerniak ◽  
Tina P. Barton ◽  
C. G. Clark ◽  
M. R. Lewin
Keyword(s):  
Duodenal Ulcer ◽  
Gastric Acid ◽  
Acid Output ◽  
Normal Subjects ◽  
Duodenal Ulceration ◽  
Control Subjects ◽  
Healthy Control ◽  
Peak Acid Output ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of

1. The blood cortisol and gastric acid responses to insulin hypoglycaemia were investigated in 18 healthy control subjects and 14 patients with endoscopically proven duodenal ulceration. 2. In both controls and patients, insulin hypoglycaemia caused blood cortisol and acid output to rise and peak simultaneously, the rises being significantly greater in patients with duodenal ulcer than in control subjects. 3. The peak acid output and the base to peak cortisol increments were also found to be significantly greater in patients with duodenal ulcer than in control subjects (P < 0.001 and P < 0.005 respectively). 4. We conclude that insulin hypoglycaemia causes stimulation of the sympathetic and parasympathetic nervous systems and of the hypothalamo-pituitary-adrenal axis, resulting in the simultaneous elevation of gastric juice acidity and blood cortisol levels. We have shown that synchronous rises in gastric acid and blood cortisol occur during insulin hypoglycaemia and that these rises are greater in patients with duodenal ulcer.

scholarly journals Antihypercholesterolemic Effects of Fruit Aqueous Extract ofCopernicia prunifera(Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Raquel Teixeira Terceiro Paim ◽  
Stephen Rathinaraj Benjamin ◽  
Davide Rondina ◽  
Márcia Maria Mendes Marques ◽  
Daniel de Araújo Viana ◽  
...  
Keyword(s):  
Body Weight ◽  
Normal Values ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Chemical Characterization ◽  
Gel Permeation Chromatography ◽  
Fruit Pulp ◽  
Weight Changes ◽  
Characterization Methods ◽  
Hypercholesterolemic Diet

The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) ofCopernicia prunifera(Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy,1H and13C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause.

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