Australia antigen and the quest for a hepatitis virus

1969 ◽  
Vol 14 (3) ◽  
pp. 189-194 ◽  
Author(s):  
Alton I. Sutnick ◽  
W. Thomas London ◽  
Baruch S. Blumberg
Keyword(s):  
Hepatitis Virus ◽  
Australia Antigen

Australia Antigen and Neonatal Hepatitis Syndrome

PEDIATRICS ◽  
1974 ◽  
Vol 54 (2) ◽  
pp. 157-164
Author(s):  
Christos A. Kattamis ◽  
Demetrios Demetrios ◽  
Nicholas S. Matsaniotis
Keyword(s):  
Hepatitis Virus ◽  
Newborn Infants ◽  
Neonatal Hepatitis ◽  
Cmv Infection ◽  
Australia Antigen ◽  
High Prevalence ◽  
The Status ◽  
Antigen Antibody ◽  
Hepatitis Type B ◽  
Hepatitis Virus B

The status of Australia antigen (Au-Ag) and Australia antigen antibody (Au-Ab) was investigated in 27 infants less than 4 months of age with direct reacting hyperbilirubinemia, and in their parents. A diagnosis of viral hepatitis could be excluded in eight infants; of the remaining 19, ten were positive for Au-Ag and another three had suggestive evidence of hepatitis virus B (HBV) infection. The high proportion of infants with neonatal hepatitis associated with Au-Ag in this series is attributed to the high prevalence of Au-Ag carriers in Greece as well as to the high frequency of exchange transfusions in newborn infants. The other 14 cases of direct-reacting hyperbilirubinemia, none of which showed Au-Ag or evidence of HBV, were due to congenital malformation of the biliary tract (four cases), septicemia (three cases), cytomegalovirus (CMV) infection (one case), and fructosemia (one case). The remaining five patients, all of whom recovered, are believed to have hepatitis virus A infection. The detection of Au-Ag in prolonged neonatal jaundice with direct bilirubinemia favors a diagnosis of hepatitis type B, which in our experience carries a graver prognosis reflected in deaths and cirrhosis when compared to neonatal hepatitis not associated with Au-Ag. In our patients, it is inferred that transmission of Au-Ag to the infants occurred at or after birth, rather than during intrauterine life.

Australia antigen as a hepatitis virus

1970 ◽  
Vol 48 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Baruch S. Blumberg ◽  
Alton I. Sutnick ◽  
Thomas London
Keyword(s):  
Hepatitis Virus ◽  
Australia Antigen

AUSTRALIA ANTIGEN, HEPATITIS VIRUS AND DOWNS SYNDROME

1970 ◽  
Vol 171 (2 Down's Syndro) ◽  
pp. 486-499 ◽  
Author(s):  
Baruch S. Blumberg ◽  
Betty Jane S. Gerstley ◽  
Alton I. Sutnick ◽  
Irving Millman ◽  
W. Thomas London
Keyword(s):  
Hepatitis Virus ◽  
Australia Antigen ◽  
Downs Syndrome

scholarly journals Australia Antigen as a Marker of Propagation of the Serum Hepatitis Virus in Liver Cultures

Nature ◽  
1972 ◽  
Vol 236 (5341) ◽  
pp. 78-81 ◽  
Author(s):  
A. J. ZUCKERMAN ◽  
PAMELA M. BAINES ◽  
JUNE D. ALMEIDA
Keyword(s):  
Hepatitis Virus ◽  
Serum Hepatitis ◽  
Australia Antigen

scholarly journals Screening for transmission of hepatitis within a liver unit

1972 ◽  
Vol 70 (1) ◽  
pp. 197-202 ◽  
Author(s):  
P. Bentley ◽  
D. Haynes ◽  
P. Sharpstone ◽  
P. E. Taylor ◽  
A. J. Zuckerman ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis Virus ◽  
Infectious Hepatitis ◽  
Australia Antigen ◽  
Staff Members ◽  
Plasma Bilirubin ◽  
Therapeutic Procedures ◽  
Serum Aspartate Aminotransferase ◽  
Persistent Elevation ◽  
Apparently Healthy

SUMMARYDetailed screening of the patients and staff in a unit specializing in liver disease was carried out over a year to ascertain whether transmission of the serum hepatitis virus was occurring and whether the situation was comparable in any way to that found in a Renal Haemodialysis Unit. Of the 154 patients with liver disease tested on admission, 6% were found to have Australia antigen in the serum and throughout the year there were rarely less than two patients in the ward at any one time with positive serum. No instances of clinical hepatitis were detected in the other patients following their stay in the ward or in their attendant medical, nursing and lay staff. Six staff members were found to have Australia antigen in their serum. In four of these, all nurses, it was present in the first sample tested and so the infection may have been acquired earlier. Temporary elevations in both plasma bilirubin and serum aspartate aminotransferase levels were found in another five staff members whose serum was negative for Australia antigen and who clinically were well. In a further eight and apparently healthy staff members, an isolated but persistent elevation of the plasma bilirubin was noted. In both groups these changes could represent the spread of subclinical infectious hepatitis and it is recommended that in units dealing with ‘liver patients’ not only should considerable care be taken during diagnostic and therapeutic procedures but the medical and nursing staff should be screened at regular intervals.

Immune Electron Microscopy (IEM) of a Canine Adeno-Associated Virus

1974 ◽  
Vol 32 ◽  
pp. 256-257
Author(s):  
Gunter F. Thomas ◽  
M. David Hoggan
Keyword(s):  
Electron Microscopy ◽  
Cell Cultures ◽  
Complement Fixation ◽  
Hepatitis Virus ◽  
Wide Distribution ◽  
Immune Electron Microscopy ◽  
Adeno Associated Virus ◽  
Virus Like Particle ◽  
Dog Kidney ◽  
Green Monkeys

In 1968, Sugimura and Yanagawa described a small 25 nm virus like particle in association with the Matsuda strain of infectious canine hepatitis virus (ICHV). Domoto and Yanagawa showed that this particle was dependent on ICHV for its replication in primary dog kidney cell cultures (PDK) and was resistant to heating at 70°C for 10 min, and concluded that it was a canine adeno-associated virus (CAAV). Later studies by Onuma and Yanagawa compared CAAV with the known human serotypes (AAV 1, 2, 3) and AAV-4, known to be associated with African Green Monkeys. Using the complement fixation (CF) test, they found that CAAV was serologically related to AAV-3 and had wide distribution in the dog population of Japan.

The assay of gosling hepatitis virus and antibody by spermagglutination and spermagglutination-inhibition I. Spermagglutination

1974 ◽  
Vol 3 (3) ◽  
pp. 189-199
Author(s):  
B. A. Peleg ◽  
M. Malkinson ◽  
Nily Ron ◽  
Elizabeth Kalmar
Keyword(s):  
Hepatitis Virus

Perbedaan Pengetahuan Siswa Tentang Penyakit Hepatitis A Sebelum Dan Sesudah Penyuluhan Di MTsN 02 Bondowoso Tahun 2015

2017 ◽  
Vol 4 (2) ◽  
pp. 14
Author(s):  
Putri Megasari
Keyword(s):  
Hepatitis A ◽  
Hepatitis Virus ◽  
Sampling Technique ◽  
Mean Value ◽  
Test Design ◽  
The World ◽  
Before And After ◽  
Post Test ◽  
The Mean ◽  
Paired T Test

Hepatitis has become a health problem in the world. The hepatitis virus infected many people. According to the teacher of MTsN 02 Bondowoso more than 20 students have hepatitis A viral infection. The purpose of this research was to know the differences of students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study used pre-experimental (pre-post test design). This study used stratified random sampling technique, 127 students from 270 sample involved this research,and 143 students was excluded. We used questionnaires to collect data. The results showed that the mean value of the students 'knowledge about hepatitis A before counseling in MTsN 02 Bondowoso 2015 was 83.96 with the lowest value of 37.5 and the highest value was 100. The mean value of the students' knowledge about hepatitis A after counseling in MTsN 02 Bondowoso 2015 was 93.21 with the lowest value waf 62.5 and the highest value was 100. Paired t test showed that t (-9.07) > t table (1.98), the null hypothesis (H0) was rejected. There was a difference between students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study showed that routine counseling by healthcare provider was important to prevent hepatitis A infection.; Keywords: counseling, knowledge of students, hepatitis

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