The role of tumor cell adhesion as an important factor in formation of distant colorectal metastasis

2001 ◽  
Vol 44 (6) ◽  
pp. 876-884 ◽  
Author(s):  
Jörg Haier ◽  
Garth L. Nicolson
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Colorectal Metastasis ◽  
Tumor Cell Adhesion

Platelet and Shear Rate Promote Tumor Cell Adhesion to Human Endothelial Extracellular Matrix - Absence of a Role for Platelet Cyclooxygenase

1989 ◽  
Vol 61 (03) ◽  
pp. 485-489 ◽  
Author(s):  
Eva Bastida ◽  
Lourdes Almirall ◽  
Antonio Ordinas
Keyword(s):  
Cell Adhesion ◽  
Shear Rate ◽  
Tumor Cell ◽  
Umbilical Vein ◽  
Blood Platelets ◽  
Flow Conditions ◽  
Tumor Cell Adhesion ◽  
Rate Dependent ◽  
Static Conditions

SummaryBlood platelets are thought to be involved in certain aspects of malignant dissemination. To study the role of platelets in tumor cell adherence to vascular endothelium we performed studies under static and flow conditions, measuring tumor cell adhesion in the absence or presence of platelets. We used highly metastatic human adenocarcinoma cells of the lung, cultured human umbilical vein endothelial cells (ECs) and extracellular matrices (ECM) prepared from confluent EC monolayers. Our results indicated that under static conditions platelets do not significantly increase tumor cell adhesion to either intact ECs or to exposed ECM. Conversely, the studies performed under flow conditions using the flat chamber perfusion system indicated that the presence of 2 × 105 pl/μl in the perfusate significantly increased the number of tumor cells adhered to ECM, and that this effect was shear rate dependent. The maximal values of tumor cell adhesion were obtained, in presence of platelets, at a shear rate of 1,300 sec-1. Furthermore, our results with ASA-treated platelets suggest that the role of platelets in enhancing tumor cell adhesion to ECM is independent of the activation of the platelet cyclooxygenase pathway.

scholarly journals Transcriptome analysis of human cancer reveals a functional role of Heme Oxygenase-1 in tumor cell adhesion

2010 ◽  
Vol 9 (1) ◽  
pp. 200 ◽  
Author(s):  
Stefanie Tauber ◽  
Alexander Jais ◽  
Markus Jeitler ◽  
Sandra Haider ◽  
Julia Husa ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Heme Oxygenase ◽  
Transcriptome Analysis ◽  
Functional Role ◽  
Human Cancer ◽  
Heme Oxygenase 1 ◽  
Tumor Cell Adhesion

scholarly journals Physical Biology in Cancer. 4. Physical cues guide tumor cell adhesion and migration

2014 ◽  
Vol 306 (2) ◽  
pp. C98-C109 ◽  
Author(s):  
Kimberly M. Stroka ◽  
Konstantinos Konstantopoulos
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Secondary Site ◽  
Tumor Cell Adhesion ◽  
Metastatic Cascade ◽  
Physical Cues ◽  
Cell Adhesion And Migration ◽  
And Migration

As tumor cells metastasize from the primary tumor location to a distant secondary site, they encounter an array of biologically and physically heterogeneous microenvironments. While it is well established that biochemical signals guide all stages of the metastatic cascade, mounting evidence indicates that physical cues also direct tumor cell behavior, including adhesion and migration phenotypes. Physical cues acting on tumor cells in vivo include extracellular matrix mechanical properties, dimensionality, and topography, as well as interstitial flow, hydrodynamic shear stresses, and local forces due to neighboring cells. State-of-the-art technologies have recently enabled us and other researchers to engineer cell microenvironments that mimic specific physical properties of the cellular milieu. Through integration of these engineering strategies, along with physics, molecular biology, and imaging techniques, we have acquired new insights into tumor cell adhesion and migration mechanisms. In this review, we focus on the extravasation and invasion stages of the metastatic cascade. We first discuss the physical role of the endothelium during tumor cell extravasation and invasion and how contractility of endothelial and tumor cells contributes to the ability of tumor cells to exit the vasculature. Next, we examine how matrix dimensionality and stiffness coregulate tumor cell adhesion and migration beyond the vasculature. Finally, we summarize how tumor cells translate and respond to physical cues through mechanotransduction. Because of the critical role of tumor cell mechanotransduction at various stages of the metastatic cascade, targeting signaling pathways involved in tumor cell mechanosensing of physical stimuli may prove to be an effective therapeutic strategy for cancer patients.

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