Diagnostic value of fecal chymotrypsin and trypsin assessment for detection of pancreatic disease

1968 ◽  
Vol 13 (2) ◽  
pp. 123-146 ◽  
Author(s):  
Rudolf W. Ammann ◽  
Ernst Tagwercher ◽  
Heihachiro Kashiwagi ◽  
Hans Rosenmund
Keyword(s):  
Diagnostic Value ◽  
Pancreatic Disease ◽  
Fecal Chymotrypsin

scholarly journals Immunoreactive elastase I: clinical evaluation of a new noninvasive test of pancreatic function

1996 ◽  
Vol 42 (2) ◽  
pp. 222-226 ◽  
Author(s):  
J Stein ◽  
M Jung ◽  
A Sziegoleit ◽  
S Zeuzem ◽  
W F Caspary ◽  
...  
Keyword(s):  
Pancreatic Insufficiency ◽  
Pancreatic Enzyme ◽  
Correlation Coefficients ◽  
Diagnostic Value ◽  
Exocrine Pancreatic Insufficiency ◽  
Pancreatic Function ◽  
Noninvasive Test ◽  
Enzyme Replacement ◽  
Fecal Chymotrypsin ◽  
Immunoreactive Elastase

Abstract We have evaluated the diagnostic value of the fecal elastase test in comparison with the secretin-pancreozymin test in the diagnosis of exocrine pancreatic insufficiency. Pancreatic elastase was measured immunologically. Immunoreactive elastase activity in spot stools from controls ranged from 136 to 4440 microgram/g; 95% of all values were within 175 to 1500 microgram/g. The elastase assay CVs ranged from 3.3% to 6.3% (intraassay) and from 4.1% to 10.2% (interassay). The output of elastase correlated well with those of amylase, lipase, and trypsin, yielding respective correlation coefficients of 0.83, 0.82, and 0.84 in controls and 0.86, 0.91, and 0.91 in patients with impaired pancreatic function. In contrast to fecal chymotrypsin, the test results were unaffected by pancreatic enzyme replacement therapy. These results indicate that fecal immunoreactive elastase may be recommended as a new, noninvasive tubeless test of pancreatic function.

scholarly journals Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions

1999 ◽  
Vol 19 (3-4) ◽  
pp. 175-185 ◽  
Author(s):  
Romana Tomaszewska ◽  
Krzysztof Okoń ◽  
Krystyna Nowak ◽  
Jerzy Stachura
Keyword(s):  
Pancreatic Cancer ◽  
Proliferative Activity ◽  
Diagnostic Value ◽  
Pancreatic Disease ◽  
Proliferation Index ◽  
Low Grade ◽  
Cell Nuclei ◽  
Ki 67 ◽  
Single Feature ◽  
Papillary Hyperplasia

The increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic neoplasia is the intraepithelial proliferation – dysplasia – cancer sequence. In the present paper we studied the proliferative activity (Ki‐67 index) in pancreatic intraepithelial proliferative lesions and its correlation with geometric features of cell nuclei as signs of increasing dysplasia. The studies were carried out in a group of 35 patients operated on for pancreatic cancer, chronic pancreatitis and other conditions not associated with the pancreas. We used immunohistochemical methods and basic morphometric parameters. The results of our studies indicate that the cell proliferative activity depends both on the type of epithelial proliferation and underlying pancreatic disease. The values of Ki‐67 index are significantly different in low‐grade proliferation (flat and papillary hyperplasia) and high‐grade proliferation (atypical papillary hyperplasia and carcinomain situ). A set of karyometric features correlates with Ki‐67 index but there is no single feature which would have a diagnostic value.

Diagnostic value of serum elastase 1 in pancreatic disease

1987 ◽  
Vol 74 (1) ◽  
pp. 44-47 ◽  
Author(s):  
L. Gullo ◽  
M. Ventrucci ◽  
R. Pezzilli ◽  
L. Platé ◽  
P. Naldoni
Keyword(s):  
Diagnostic Value ◽  
Pancreatic Disease ◽  
Elastase 1

4553 Diagnostic value of eus image texture analysis in pancreatic disease.

2000 ◽  
Vol 51 (4) ◽  
pp. AB166
Author(s):  
Prat Frederic ◽  
Lefebvre Francoise ◽  
Amichi Ahmed ◽  
Zidi Semia ◽  
Laugier Pascal ◽  
...  
Keyword(s):  
Texture Analysis ◽  
Diagnostic Value ◽  
Pancreatic Disease ◽  
Image Texture ◽  
Image Texture Analysis

Fecal chymotrypsin and elastase-1 determination on one single stool collected at random: diagnostic value for exocrine pancreatic status

2004 ◽  
Vol 37 (9) ◽  
pp. 758-763 ◽  
Author(s):  
Isabelle Molinari ◽  
Karamo Souare ◽  
Thierry Lamireau ◽  
Michael Fayon ◽  
Catherine Lemieux ◽  
...  
Keyword(s):  
Diagnostic Value ◽  
Elastase 1 ◽  
Fecal Chymotrypsin
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