scholarly journals Simulation of the electric-control activity of the stomach by an array of relaxation oscillators

1972 ◽  
Vol 17 (5) ◽  
pp. 477-477
Author(s):  
S. K. Sarna ◽  
E. E. Daniel ◽  
Y. J. Kingma
Keyword(s):  
Control Activity ◽  
Relaxation Oscillators ◽  
Electric Control

An application of nonlinear forecasting to gastric electric control activity

1992 ◽  
Vol 103 (4) ◽  
pp. 1397
Author(s):  
J.M. Joyce ◽  
D.R. Sinar ◽  
S.P. Ellis
Keyword(s):  
Control Activity ◽  
Electric Control ◽  
Nonlinear Forecasting

scholarly journals Targeting multiple genes containing long mononucleotide A-T repeats in lung cancer stem cells

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Narumol Bhummaphan ◽  
Piyapat Pin-on ◽  
Preeyaporn Plaimee Phiboonchaiyanan ◽  
Jirattha Siriluksana ◽  
Chatchawit Aporntewan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Cell ◽  
Transcriptional Control ◽  
Single Gene ◽  
Repeat Sequence ◽  
Control Activity ◽  
Multiple Genes ◽  
Lung Cancer Stem Cells

Abstract Background Intratumour heterogeneous gene expression among cancer and cancer stem cells (CSCs) can cause failure of current targeted therapies because each drug aims to target the function of a single gene. Long mononucleotide A-T repeats are cis-regulatory transcriptional elements that control many genes, increasing the expression of numerous genes in various cancers, including lung cancer. Therefore, targeting A-T repeats may dysregulate many genes driving cancer development. Here, we tested a peptide nucleic acid (PNA) oligo containing a long A-repeat sequence [A(15)] to disrupt the transcriptional control of the A-T repeat in lung cancer and CSCs. Methods First, we separated CSCs from parental lung cancer cell lines. Then, we evaluated the role of A-T repeat gene regulation by counting the number of repeats in differentially regulated genes between CSCs and the parental cells of the CSCs. After testing the dosage and effect of PNA-A15 on normal and cancer cell toxicity and CSC phenotypes, we analysed genome-wide expression to identify dysregulated genes in CSCs. Results The number of A-T repeats in genes differentially regulated between CSCs and parental cells differed. PNA-A15 was toxic to lung cancer cells and CSCs but not to noncancer cells. Finally, PNA-A15 dysregulated a number of genes in lung CSCs. Conclusion PNA-A15 is a promising novel targeted therapy agent that targets the transcriptional control activity of multiple genes in lung CSCs.

Design of Electric Control System of Stainless Steel Composite Plate

2013 ◽  
Vol 706-708 ◽  
pp. 716-719
Author(s):  
Jian Chu ◽  
Gang Wang
Keyword(s):  
Stainless Steel ◽  
Control System ◽  
Composite Plate ◽  
Current Control ◽  
Equipment Operation ◽  
Electric Control ◽  
Control Scheme ◽  
Steel Composite ◽  
Machine Interface ◽  
Electrical Components

This paper mainly introduced to the PLC as the core of stainless steel composite plate electric control part of the design. The system uses the converter +PLC+ man-machine interface, as the major part of roll welding machine control, because of the use of the PLC, so that the system can improve the automatic level, electrical components is reduced, reduce failure rate, improve the reliability of equipment operation. Based on the current control and speed control, so that the welding quality and welding speed has been greatly improved. In the article, mainly from the production process, and the control system hardware and software design, and the control scheme to introduce several aspects.

Biological control of Fusarium wilt of cucumber with nonpathogenic isolates of Fusarium oxysporum

1987 ◽  
Vol 33 (5) ◽  
pp. 349-353 ◽  
Author(s):  
T. C. Paulitz ◽  
C. S. Park ◽  
R. Baker
Keyword(s):  
Biological Control ◽  
Fusarium Oxysporum ◽  
Infection Rate ◽  
Fusarium Wilt ◽  
Disease Incidence ◽  
Infection Rates ◽  
Control Activity ◽  
Significant Difference ◽  
Cucumber Roots ◽  
Linear Regressions

Nonpathogenic isolates of Fusarium oxysporum were obtained from surface-disinfested, symptomless cucumber roots grown in two raw (nonautoclaved) soils. These isolates were screened for pathogenicity and biological control activity against Fusarium wilt of cucumber in raw soil infested with Fusarium oxysporum f. sp. cucumerinum (F.o.c.). The influence of three isolates effective in inducing suppressiveness and three ineffective isolates on disease incidence over time was tested. The effective isolates reduced the infection rate (R), based on linear regressions of data transformed to loge (1/1 – y). Effective isolate C5 was added to raw soil infested with various inoculum densities of F.o.c. In treatments without C5, the increase in inoculum densities of F.o.c. decreased the incubation period of wilt disease, but there was no significant difference in infection rate among the inoculum density treatments. Isolate C5 reduced the infection rate at all inoculum densities of F.o.c. Various inoculum densities of C5 were added to raw soils infested with 1000 cfu/g of F.o.c. In the first trial, infection rates were reduced only in the treatment with 10 000 cfu/g of C5; in the second trial, infection rates were reduced in treatments with 10 000 and 30 000 cfu/g of C5.

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