Synthesis and diuretic activity of N-substituted condensed derivatives of 3-methylxanthine with endocyclic sulfur atom

1996 ◽  
Vol 30 (3) ◽  
pp. 194-196 ◽  
Author(s):  
N. I. Romanenko ◽  
I. V. Fedulova ◽  
B. A. Priimenko ◽  
N. A. Klyuev ◽  
T. A. Pereverzeva ◽  
...  
Keyword(s):  
Sulfur Atom ◽  
Diuretic Activity ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Diuretic Activity of N-Substituted Condensed Derivatives of 3-Methylxanthine with Endocyclic Sulfur Atom.

ChemInform ◽  
2010 ◽  
Vol 27 (31) ◽  
pp. no-no
Author(s):  
N. I. ROMANENKO ◽  
I. V. FEDULOVA ◽  
B. A. PRIIMENKO ◽  
N. A. KLYUEV ◽  
T. A. PEREVERZEVA ◽  
...  
Keyword(s):  
Sulfur Atom ◽  
Diuretic Activity ◽  
Derivatives Of

scholarly journals Important of Azoles

2019 ◽  
pp. 6-14
Keyword(s):  
Organic Compounds ◽  
Sulfur Atom ◽  
Ring Structure ◽  
Derivatives Of

Azoles are one of a cyclic  derivatives  of chemical  heterocyclic chemical and organic compounds including g a five member di unsaturated ring structure composed of  bi  nitrogen atoms at position (3 and 4) and one sulfur atom at position (1).

Synthesis of cyclopentane analogs of (2′- and 3′-deoxy-erythro-pentofuranosyl and ribofuranosyl)-2-thiouracil nucleosides

1986 ◽  
Vol 64 (8) ◽  
pp. 1620-1629 ◽  
Author(s):  
Lucjan J.J. Hronowski ◽  
Walter A. Szarek
Keyword(s):  
Sulfur Atom ◽  
Nmr Spectra ◽  
Aqueous Ammonia ◽  
Synthetic Route ◽  
Nmr Spectrum ◽  
H Nmr ◽  
Synthetic Intermediates ◽  
Derivatives Of ◽  
Sulfur Containing ◽  
Sulfur Containing Compounds

Three new carbocyclic analogs of nucleosides having the 2-thiouracil base have been synthesized. The cyclopentyl groups in these nucleosides are (±)-{(1β,3α,4β)-3-hydroxy-4-(hydroxyrnethyl)cyclopentyl} (see 31), (±)-{(1β,2α,4β)-2-hydroxy-4-(hydroxymethyl)cyclopentyl} (see 32), and (±)-{(1β,2α,3α,4β)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl} (see 33). The nucleosides were prepared by coupling the appropriate hydroxy derivatives of cis-3-aminocyclopentanemethanol with 3-ethoxypropenoyl isothiocyanate (21) followed by cyclization in 15 N aqueous ammonia to give the 2-thiouracil nucleosides. In addition a modified and shortened synthetic route is described for the synthesis of (±)-(1β,2α,3α,4β)-4-amino-2,3-dihydroxy-cyclopentanemethanol (19). The 1H nmr spectra at 200 MHz of all of the synthetic intermediates, the 2-thiouracil nucleosides, and of the corresponding carbocyclic analogs of uracil nucleosides are discussed. It is shown that each nucleoside has a characteristically unique 1H nmr spectrum and that in general the protons in the sulfur-containing compounds resonate at lower fields than those in the corresponding oxygen-containing compounds. The magnitude of this downfield shift is inversely related to the number of bonds separating a particular proton from the sulfur atom.

scholarly journals Important of Azoles

2019 ◽  
Vol 1 (1) ◽  
pp. 6-14
Author(s):  
Medhat Mahamed Zakaria
Keyword(s):  
Organic Compounds ◽  
Sulfur Atom ◽  
Spectroscopic Properties ◽  
Ring Structure ◽  
Derivatives Of

Azoles are one of a cyclic  derivatives  of chemical  heterocyclic chemical and organic compounds including g a five member di unsaturated ring structure composed of  bi  nitrogen atoms at position (3 and 4) and one sulfur atom at position (1).        Most of prepared  work on the four thiadiazoles has been on the 1, 3, 4-thiadiazoles. Physical, theoretical, and spectroscopic properties have been reviewed .

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