Synthesis and biological activity of N-acyl derivatives of 3-amino-2-ethoxycarbonylacrylamides

1996 ◽  
Vol 30 (1) ◽  
pp. 36-37
Author(s):  
A. I. Mikhalev ◽  
M. L. Suslina ◽  
T. M. Kon'shina ◽  
A. S. Zaks ◽  
M. E. Kon'shin
Keyword(s):  
Biological Activity ◽  
Derivatives Of ◽  
Acyl Derivatives

ChemInform Abstract: Synthesis and Biological Activity of N-Acyl Derivatives of 3-Amino-2- ethoxycarbonylacrylamides.

ChemInform ◽  
2010 ◽  
Vol 27 (30) ◽  
pp. no-no
Author(s):  
A. I. MIKHALEV ◽  
M. L. SUSLINA ◽  
T. M. KON'SHINA ◽  
A. S. ZAKS ◽  
M. E. KON'SHIN
Keyword(s):  
Biological Activity ◽  
Derivatives Of ◽  
Acyl Derivatives

Synthesis, structure, and biological activity of ?-acyl derivatives of \-N-R-oxamoylphenylhydrazines

1984 ◽  
Vol 18 (1) ◽  
pp. 17-20 ◽  
Author(s):  
S. G. Taran ◽  
P. A. Bezuglyi ◽  
I. T. Depeshko ◽  
Yu. A. Golubenko
Keyword(s):  
Biological Activity ◽  
Derivatives Of ◽  
Acyl Derivatives

ChemInform Abstract: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ACYL DERIVATIVES OF 1-PHENYL-2,3-DIMETHYL-4-AMINOPYRAZOL-5-ONE

1981 ◽  
Vol 12 (46) ◽  
Author(s):  
V. G. VORONIN ◽  
Z. I. SHRAMOVA ◽  
V. A. ALESHINA ◽  
A. S. ZAKS ◽  
E. L. PIDEMSKII ◽  
...  
Keyword(s):  
Biological Activity ◽  
Derivatives Of ◽  
Acyl Derivatives

Synthesis and biological activity of 4″-O-acyl derivatives of 14- and 15-membered macrolides linked to ω-quinolone-carboxylic unit

2010 ◽  
Vol 18 (17) ◽  
pp. 6547-6558 ◽  
Author(s):  
Maja Matanović Škugor ◽  
Vlado Štimac ◽  
Ivana Palej ◽  
Đurdjica Lugarić ◽  
Hana Čipčić Paljetak ◽  
...  
Keyword(s):  
Biological Activity ◽  
Derivatives Of ◽  
Acyl Derivatives

Biological activity of transformed steroids. VI. The synthesis and hormonal activity of N-acyl derivatives of 6?-fluoro-3?-methylandrost-4-en-3-one[17, 16-d]pyrazoles

1976 ◽  
Vol 10 (9) ◽  
pp. 1164-1168 ◽  
Author(s):  
A. I. Terekhina ◽  
G. I. Gritsina ◽  
A. V. Kamernitskii ◽  
L. I. Lisitsa ◽  
N. N. Neshchadim ◽  
...  
Keyword(s):  
Biological Activity ◽  
Hormonal Activity ◽  
Derivatives Of ◽  
Acyl Derivatives

Synthesis and biological activity of acyl derivatives of 4-amino-2,3-dimethyl-1-phenylpyrazol-5-one

1981 ◽  
Vol 15 (6) ◽  
pp. 396-399
Author(s):  
V. G. Voronon ◽  
Z. I. Shramova ◽  
V. A. Aleshina ◽  
A. S. Zaks ◽  
E. L. Pidemskii ◽  
...  
Keyword(s):  
Biological Activity ◽  
Derivatives Of ◽  
Acyl Derivatives

scholarly journals STUDY OF THE AFFINITY OF N-ACYL DERIVATIVES OF 2-OXO-1-PYRROLIDINE ACETAMIDE TO THE BINDING SITE OF NMDA RECEPTOR BY MOLECULAR DOCKING METHOD

2019 ◽  
pp. 4-6
Author(s):  
A.S. Chiriapkin ◽  
A.A. Glushko ◽  
I.P. Kodonidi
Keyword(s):  
Biological Activity ◽  
Molecular Docking ◽  
Nmda Receptor ◽  
Binding Site ◽  
Computational Method ◽  
In Vivo Studies ◽  
Docking Method ◽  
Derivatives Of ◽  
Acyl Derivatives

The search for new compounds with а high nootropic biological activity is a promising scientific direction. A modern computational method for predicting pharmacological activity of the studied compounds is the molecular docking. The aim of this work is to study the affinity of new N-acyl derivatives of 2-oxo-1-pyrrolidine acetamide to the binding site of NMDA receptor to search of new effective nootropic drugs. As objects of study, there are used the new N-acyl derivatives of 2-oxo-1-pyrrolidine acetamide, racetams, glutamate and a virtual model of NMDA receptor of organism Rattus norvegicus with an identification code 2A5S from the RCSB PDB database. The results of the computational experiment indicate the presence of high nootropic biological activity in the compounds under study. Substance 3 has the greatest affinity of the N-acyl derivatives of 2-oxo-1-pyrrolidineethanol to the binding site of NMDA receptor Thus, we consider it is appropriate to conduct pharmacological in vivo studies of these compounds for the presence of nootropic biological activity.

Synthesis and Biological Activity of N- and O-Acyl Derivatives of 2,6-Diphenyl-4-hydroxypiperidines and Tetrahydropyridines.

ChemInform ◽  
2004 ◽  
Vol 35 (10) ◽  
Author(s):  
A. T. Soldatenkov ◽  
A. N. Levov ◽  
I. G. Mobio ◽  
E. V. Polyakova ◽  
S. V. Kutyakov ◽  
...  
Keyword(s):  
Biological Activity ◽  
Derivatives Of ◽  
Acyl Derivatives
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