Mechanisms of biliary excretion of lithocholate-3-sulfate in Eisai hyperbilirubinemic rats (EHBR)

1995 ◽  
Vol 40 (8) ◽  
pp. 1792-1797 ◽  
Author(s):  
Hajime Takikawa ◽  
Kou Nishikawa ◽  
Naoyo Sano ◽  
Masami Yamanaka ◽  
Tohru Horie
Keyword(s):  
Biliary Excretion ◽  
Eisai Hyperbilirubinemic Rats

Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123

1997 ◽  
Vol 272 (5) ◽  
pp. G979-G986
Author(s):  
H. C. Shin ◽  
Y. Kato ◽  
T. Yamada ◽  
K. Niinuma ◽  
A. Hisaka ◽  
...  
Keyword(s):  
Biliary Excretion ◽  
Organic Anion ◽  
Membrane Vesicles ◽  
Organic Anion Transporter ◽  
Canalicular Membrane ◽  
Hepatobiliary Transport ◽  
Anion Transporter ◽  
Eisai Hyperbilirubinemic Rats ◽  
Endothelin Antagonist

The hepatobiliary transport of an anionic cyclopentapeptide endothelin antagonist, BQ-123, was studied in rats. Biliary excretion of [3H]BQ-123 was extensive in vivo (approximately 75% of intravenous infusion rates). Liver-to-plasma and bile-to-liver concentration ratios at steady state were approximately 3 and 200, respectively, suggesting that hepatic uptake and biliary excretion are concentrative processes. The biliary excretion clearance exhibited a saturation at a hepatic concentration of > 100 nmol/g liver and was markedly reduced in Eisai hyperbilirubinemic rats, which have a hereditary defect of canalicular multispecific organic anion transporter. An ATP-dependent and saturable uptake of BQ-123 by isolated canalicular membrane vesicles was observed in vitro. Impaired transport of BQ-123 was also confirmed in canalicular membrane vesicles prepared from Eisai hyperbilirubinemic rats. These results demonstrate that the biliary excretion process is ATP-driven primary active transport. It is proposed that a canalicular multispecific organic anion transporter is mainly responsible for the biliary excretion of BQ-123.

Hepatobiliary Kinetics of 113mIn-Phenolphthalexon

1981 ◽  
Vol 20 (02) ◽  
pp. 90-93
Author(s):  
P.B. Parab ◽  
U.R. Raikar ◽  
R.D. Ganatra ◽  
M. C. Patel
Keyword(s):  
Biliary Excretion ◽  
Iminodiacetic Acid ◽  
Organ Distribution ◽  
Liver Uptake ◽  
On Line ◽  
Rapid Clearance ◽  
Chemical Purity ◽  
Kinetics Of ◽  
High Liver

Phenolphthalexon, a compound with iminodiacetic acid as a functional group, has been labelled with 113mIn to high chemical purity and its usefulness in studies of biliary excretion patency has been studied. Organ distribution of 113mIn-phenolphthalexon in mice was characterized by high liver uptake (50.8% of the administered dose after 5 min) and rapid clearance through the gall bladder. An animal model for studying obstruction of biliary excretion has been developed. Data on the kinetics of the radiopharmaceutical were obtained by collecting in-vivo data through an on-line computer.

scholarly journals The methylimidazolium ionic liquid M8OI is detectable in human sera and is subject to biliary excretion in perfused human liver

Toxicology ◽  
2021 ◽  
pp. 152854
Author(s):  
Alistair C. Leitch ◽  
Ibrahim Ibrahim ◽  
Tarek M. Abdelghany ◽  
Alex Charlton ◽  
Clair Roper ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Biliary Excretion ◽  
Human Liver ◽  
Human Sera

Metabolism and biliary excretion of phenanthridinium salts—II

1972 ◽  
Vol 21 (12) ◽  
pp. 1679-1696 ◽  
Author(s):  
James T. MacGregor ◽  
Thomas W. Clarkson
Keyword(s):  
Biliary Excretion

scholarly journals Kinetic measurements of the biliary excretion of metabolized compounds

1980 ◽  
Vol 188 (2) ◽  
pp. 561-564
Author(s):  
G M Powell ◽  
J G Jones ◽  
C G Curtis
Keyword(s):  
Kinetic Parameters ◽  
Cholic Acid ◽  
Biliary Excretion ◽  
Kinetic Measurements

1. Rats received constant infusions of bromosulphophthalein or [carboxy-14C]cholic acid at a range of concentrations. 2. Kinetic parameters describing the biliary excretion of the compounds were determined. 3. The biliary excretion of both compounds could be described by the same kinetic parameters already calculated for phenolphthalein disulphate, which is excreted in the bile unchanged.

Sex Differences of Hepatic Conjugation of Bilirubin Determine its Maximal Biliary Excretion in Non-Anaesthetized Male and Female Rats

1983 ◽  
Vol 64 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Maurizio Muraca ◽  
Jan De Groote ◽  
Johan Fevery
Keyword(s):  
Biliary Excretion ◽  
High Performance ◽  
Relative Proportion ◽  
Female Rats ◽  
Male Rats ◽  
Transferase Activity ◽  
Hepatic Transport ◽  
Male And Female Rats ◽  
Udp Glucuronosyltransferase ◽  
Rate Limiting

1. Hepatic bilirubin UDP-glucuronosyltransferase activity was higher in female than in male rats; gonadectomy decreased enzyme activity in females and increased it in males. This sex difference in bilirubin conjugation was further used to evaluate the effect of differences in conjugation on the maximal biliary excretion of bilirubin in the non-anaesthetized rat. 2. After infusion of bilirubin, the maximal biliary excretory rate (Tm) and maximal concentration of bilirubin in bile were respectively 70% and 40% higher in female than in male rats; these values were decreased in females after ovariectomy and increased in males after orchiectomy. A linear relationship was found (r = 0.86; P < 0.001) between bilirubin Tm and hepatic bilirubin UDP-glucuronosyltransferase activity in the four groups of rats, suggesting that conjugation was the rate-limiting step for the maximal hepatic transport of bilirubin. 3. At the end of bilirubin infusion, bilirubin conjugates in serum, determined by alkaline methanolysis and high-performance liquid chromatography, ranged from 0.5 to 1.4% of total bilirubin. Therefore no significant reflux of conjugated bilirubin occurred during saturation of the hepatic transport of the pigment, once more suggesting that the secretory step was not rate-limiting. 4. The composition of bilirubin conjugates in bile was similar in the four groups of rats, despite significant differences in transferase activity. This suggests that the relative proportion of bilirubin mono- and di-conjugates in bile is affected by factors other than transferase activity alone. Relatively more monoconjugates were excreted under the bilirubin load than in basal conditions.

Homeostatic control of manganese excretion in the neonatal rat

1987 ◽  
Vol 252 (5) ◽  
pp. R842-R847 ◽  
Author(s):  
N. Ballatori ◽  
E. Miles ◽  
T. W. Clarkson
Keyword(s):  
Trace Metal ◽  
Biliary Excretion ◽  
Intraperitoneal Injection ◽  
Neonatal Rat ◽  
Abrupt Increase ◽  
Adult Rats ◽  
Tracer Dose ◽  
Diminished Capacity ◽  
Carrier Free ◽  
Old Rats

Previous studies in neonatal and suckling animals showed that immature animals have a greatly diminished capacity to excrete manganese and therefore were considered to be unable to regulate tissue manganese concentrations. In contrast, the present studies indicate that suckling rats have the capacity to excrete excess manganese at rates nearly comparable to those of adults. Eight- to 10-day-old rats given a tracer dose of 54MnCl2 (essentially carrier free), either via gavage or by intraperitoneal injection showed little elimination of the 54Mn until the 18-19th day of life, when there was an abrupt increase in the rate of the metal's excretion. However, when manganese was given in doses of 1 and 10 mg/kg, the young animals excreted from 30-70% of the dose in only 4 days, at which time a new rate of excretion was achieved. This enhanced rate of excretion remained constant until the 18-19th day of life, when it was again accelerated. Biliary excretion of manganese, the primary route for the elimination of the metal, was only 30-60% lower in 14-day-old rats compared with adults at doses ranging from tracer to 10 mg 54Mn/kg. For both the 14-day-old and adult rats, an apparent biliary transport maximum was reached at a dose of 10 mg Mn/kg. These studies indicate that the excretory pathways for manganese are well developed in the neonatal rat. The avid retention of tracer quantities of manganese by the neonate may be a consequence of the scarcity of this essential trace metal in its diet.

scholarly journals Effect of a bacterial lipopolysaccharide on biliary excretion of a beta- lactam antibiotic, cefoperazone, in rats

1995 ◽  
Vol 39 (10) ◽  
pp. 2258-2261 ◽  
Author(s):  
S. Haghgoo ◽  
T. Hasegawa ◽  
M. Nadai ◽  
L. Wang ◽  
T. Nabeshima ◽  
...  
Keyword(s):  
Biliary Excretion ◽  
Bacterial Lipopolysaccharide ◽  
Beta Lactam ◽  
Beta Lactam Antibiotic ◽  
Lactam Antibiotic

Biliary excretion of digitoxin and its metabolites in young and old male wistar rats

1982 ◽  
Vol 17 (6) ◽  
pp. 407-416 ◽  
Author(s):  
K KITANI ◽  
S KANAI ◽  
Y SATO ◽  
M NOKUBO
Keyword(s):  
Biliary Excretion ◽  
Wistar Rats ◽  
Male Wistar Rats
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