Automated production of carbon-11 labelled acetate to allow detection of transient myocardial ischemia in man, using positron emission tomography

1984 ◽  
Vol 87 (1) ◽  
pp. 1-13 ◽  
Author(s):  
G. Del Fioe ◽  
J. M. Peters ◽  
L. Quaglia ◽  
J. L. Piette ◽  
R. Cantineau ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Myocardial Ischemia ◽  
Emission Tomography ◽  
Automated Production ◽  
Positron Emission ◽  
Transient Myocardial Ischemia

scholarly journals [18F]FEDAC translocator protein positron emission tomography–computed tomography for early detection of mitochondrial dysfunction secondary to myocardial ischemia

2021 ◽  
Author(s):  
Rui Luo ◽  
Lei Wang ◽  
Fei Ye ◽  
Yan-Rong Wang ◽  
Wei Fang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Early Detection ◽  
Myocardial Ischemia ◽  
Mitochondrial Dysfunction ◽  
High Performance ◽  
Dynamic Imaging ◽  
Translocator Protein ◽  
Emission Tomography ◽  
Positron Emission

Abstract Background This study aimed to evaluate the biodistribution and kinetics of [18F]FEDAC targeting the translocator protein TSPO in the myocardium, and to explore its use for the identification of mitochondrial dysfunction. We also assessed the feasibility of [18F]FEDAC for the early detection of mitochondrial dysfunction associated with myocardial ischemia (MI). Methods The radiochemical purity and stability of [18F]FEDAC were analyzed by radio-high-performance liquid chromatography (radio-HPLC). Its biodistribution and kinetics were evaluated by dissection and dynamic imaging using micro-positron emission tomography–computed tomography (micro-PET–CT) in healthy mice. [18F]FEDAC was also applied in an MI rat model and in sham-operated controls. Mitochondrial changes were observed by immunohistochemical staining and electron microscopy. Results Radioactivity levels (%ID/g) in the myocardium in normal mice, determined by [18F]FEDAC, were 8.32 ± 0.80 at 5 min and 2.40 ± 0.10 at 60 min. PET showed significantly decreased uptake by injured cardiac tissue in MI rats, with maximal normal-to-ischemic uptake ratios of 10.47 ± 3.03 (1.5 min) and 3.92 ± 1.12 (27.5 min) (P = 0.025). Immunohistochemistry confirmed that TSPO expression was decreased in MI rats. Mitochondrial ultrastructure demonstrated significant swelling and permeability. Conclusion [18F]FEDAC uptake is reduced in the injured myocardium, consistent with mitochondrial dysfunction. These results may provide new evidence to aid the early detection of mitochondrial dysfunction associated with myocardial ischemic injury.

scholarly journals Extent of Myocardial Ischemia on Positron Emission Tomography and Survival Benefit With Early Revascularization

2019 ◽  
Vol 74 (13) ◽  
pp. 1645-1654 ◽  
Author(s):  
Krishna K. Patel ◽  
John A. Spertus ◽  
Paul S. Chan ◽  
Brett W. Sperry ◽  
Randall C. Thompson ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Myocardial Ischemia ◽  
Survival Benefit ◽  
Emission Tomography ◽  
Positron Emission ◽  
Early Revascularization

scholarly journals Clinical Value of Positron Emission Tomography(PET) Using Automated Production System of Oxygen-15 Water.

RADIOISOTOPES ◽  
1996 ◽  
Vol 45 (11) ◽  
pp. 689-695
Author(s):  
Yoshiharu YONEKURA ◽  
Yoshio ISHIDA ◽  
Yasuhiro MAGATA ◽  
Yoshinori MIYAKE ◽  
Kohei HAYASHIDA ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Production System ◽  
Emission Tomography ◽  
Clinical Value ◽  
Automated Production ◽  
Positron Emission ◽  
Oxygen 15 Water
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