Multiple use of plants: Studies on selenium incorporation in some agricultural species for the production of organic selenium compounds

1991 ◽  
Vol 41 (1) ◽  
pp. 69-88 ◽  
Author(s):  
Svante Nyberg
Keyword(s):  
Multiple Use ◽  
Selenium Compounds ◽  
Organic Selenium ◽  
Agricultural Species

scholarly journals Aromatic Selenocyanates as a New Class of Non-Mutagenic Antimicrobial Selenium Compounds with Pronounced Activity against Multidrug Resistant ESKAPE Bacteria

2018 ◽  
Author(s):  
Muhammad Jawad Nasim ◽  
Karolina Witek ◽  
Annamaria Kincses ◽  
Muhammad Sarfraz ◽  
Ewa Żesławska ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Multidrug Resistant ◽  
Synthetic Chemistry ◽  
High Biological Activity ◽  
Selenium Compounds ◽  
X Ray Crystallography ◽  
Organic Selenium ◽  
Interesting Class ◽  
Mrsa Strains

Selenocyanates form an interesting class of organic selenium compounds as they serve as multifunctional agents (being the precursors of seleninic acids and diselenides in synthetic chemistry and as antimicrobial and cytotoxic agent in biology) and, due to their similarity with better known thiocyanates promise high biological activity. Yet whilst selenocyanates are common in synthetic chemistry, they are rarely considered in pharmaceutical design. Arylmethyl selenocyanates (1-13) have been synthesized and an insight into their structural properties using X-ray crystallography has been obtained. The compounds subsequently have been evaluated for their potential antimicrobial, nematicidal and cytotoxic activity. ADMET properties in vitro, using mutagenicity (AMES) and permeability (PAMPA) tests, have been determined. The compounds exhibit pronounced activity against various strains of bacteria (both Gram-positive and Gram-negative) and yeasts. Among them, benzylselenocyanate (1) represents the most active anti-ESKAPE agent, with potent antibacterial activity, especially against multidrug resistant MRSA strains (HEMSA 5). Our results demonstrate that the arylmethyl selenocyantes are not only non-mutagenic but also possess moderate cytotoxic activity against cancer cells.

scholarly journals Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

2018 ◽  
Vol 127 ◽  
pp. 80-97 ◽  
Author(s):  
Valentina Gandin ◽  
Prajakta Khalkar ◽  
Jeremy Braude ◽  
Aristi P. Fernandes
Keyword(s):  
Cancer Treatment ◽  
Chemotherapeutic Agents ◽  
Selenium Compounds ◽  
Organic Selenium

Biotransformation of organic selenium compounds in budding yeast,Saccharomyces cerevisiae

Metallomics ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1257-1263 ◽  
Author(s):  
Yasumitsu Ogra ◽  
Maya Shimizu ◽  
Kazuaki Takahashi ◽  
Yasumi Anan
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Budding Yeast ◽  
Yeast Saccharomyces Cerevisiae ◽  
Selenium Compounds ◽  
Organic Selenium ◽  
Selenoamino Acids

Organic selenium metabolites of plants and animals such as selenoamino acids and selenosugars are metabolized to selenomethionine in yeast.

The insertion of functional groups in organic selenium compounds promote changes in mitochondrial parameters and raise the antibacterial activity

2020 ◽  
Vol 98 ◽  
pp. 103727
Author(s):  
Sílvio Terra Stefanello ◽  
Caren Rigon Mizdal ◽  
Débora Farina Gonçalves ◽  
Diane Duarte Hartmann ◽  
Fernando Dobrachinski ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Functional Groups ◽  
Selenium Compounds ◽  
Organic Selenium

Dipole moments and structure of several organic selenium compounds

1967 ◽  
Vol 7 (2) ◽  
pp. 222-225
Author(s):  
L. M. Kataeva ◽  
E. G. Kataev ◽  
T. G. Mannafov
Keyword(s):  
Dipole Moments ◽  
Selenium Compounds ◽  
Organic Selenium
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