Natural history of subfoveal pigment epithelial detachments associated with subfoveal or unidentifiable choroidal neovascularization complicating age-related macular degeneration

1989 ◽  
Vol 227 (6) ◽  
pp. 501-507 ◽  
Author(s):  
Lawrence J. Singerman ◽  
Jeffrey H. Stockfish
Keyword(s):  
Natural History ◽  
Macular Degeneration ◽  
Choroidal Neovascularization ◽  
Age Related Macular Degeneration ◽  
Pigment Epithelial ◽  
Age Related ◽  
History Of

scholarly journals Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration

Ophthalmology ◽  
2019 ◽  
Vol 126 (2) ◽  
pp. 261-273 ◽  
Author(s):  
Jeannette J. Yu ◽  
Elvira Agrón ◽  
Traci E. Clemons ◽  
Amitha Domalpally ◽  
Freekje van Asten ◽  
...  
Keyword(s):  
Natural History ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Pigment Epithelial Detachment ◽  
Pigment Epithelial ◽  
Age Related ◽  
History Of

Natural History of Treatment-Naïve Quiescent Choroidal Neovascularization in Age-Related Macular Degeneration Using OCT Angiography

2018 ◽  
Vol 2 (9) ◽  
pp. 922-930 ◽  
Author(s):  
Adriano Carnevali ◽  
Riccardo Sacconi ◽  
Lea Querques ◽  
Alessandro Marchese ◽  
Vittorio Capuano ◽  
...  
Keyword(s):  
Natural History ◽  
Macular Degeneration ◽  
Choroidal Neovascularization ◽  
Age Related Macular Degeneration ◽  
Oct Angiography ◽  
Age Related ◽  
Treatment Naïve ◽  
History Of

scholarly journals Natural History of Drusen Morphology in Age-Related Macular Degeneration Using Spectral Domain Optical Coherence Tomography

Ophthalmology ◽  
2011 ◽  
Vol 118 (12) ◽  
pp. 2434-2441 ◽  
Author(s):  
Zohar Yehoshua ◽  
Fenghua Wang ◽  
Philip J. Rosenfeld ◽  
Fernando M. Penha ◽  
William J. Feuer ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Natural History ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Age Related ◽  
History Of

Retinal Thickness Changes throughout the Natural History of Drusen in Age-related Macular Degeneration

2018 ◽  
Vol 95 (8) ◽  
pp. 648-655 ◽  
Author(s):  
Lisa Nivison-Smith ◽  
Henrietta Wang ◽  
Nagi Assaad ◽  
Michael Kalloniatis
Keyword(s):  
Natural History ◽  
Macular Degeneration ◽  
Retinal Thickness ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
History Of

scholarly journals Subthreshold Exudative Choroidal Neovascularization Associated With Age-Related Macular Degeneration Identified by Optical Coherence Tomography Angiography

2020 ◽  
Vol 4 (5) ◽  
pp. 377-385
Author(s):  
Miin Roh ◽  
Joan W. Miller ◽  
Karen W. Jeng-Miller ◽  
Jay C. Wang ◽  
Inês Laíns ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Choroidal Neovascularization ◽  
Age Related Macular Degeneration ◽  
Fundus Photography ◽  
Pigment Epithelial Detachment ◽  
Optical Coherence ◽  
Pigment Epithelial ◽  
Anti Vegf ◽  
Age Related

Purpose: This article describes the clinical and multimodal imaging characteristics of subthreshold exudative choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD). Methods: Among 3773 patients with AMD, 8 eyes (6 patients) were identified with the clinical phenotype of interest. Dilated fundus examinations, color fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography (OCT), and OCT angiography (OCTA) were performed. Results: OCT typically showed a moderately reflective irregular pigment epithelial detachment with overlying subretinal fluid (SRF). Traditional FA did not show leakage and ICGA showed no definitive neovascular network or hot spots. However, OCTA clearly demonstrated a CNV within the pigment epithelial detachment. The majority of our cases (7 of 8) did not receive antivascular endothelial growth factor (anti-VEGF) injections, and visual acuity remained stable over the available follow-up period of 1 to 10 years. Conclusions: CNV is often associated with SRF and vision loss in AMD, usually requiring frequent anti-VEGF injections. OCTA allowed us to better identify CNV not readily detected on FA and ICGA. Although some have suggested early clinical intervention with anti-VEGF injections in any case with fluid and confirmed CNV on OCTA, we describe a subset of AMD patients with SRF who may be better managed by observation. These cases may represent a more indolent, mature, and stable vascular network.

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