Stability and local anaesthetic effect in some derivatives of “Xylocaine”

1955 ◽  
Vol 11 (7) ◽  
pp. 275-276 ◽  
Author(s):  
A. Sekera ◽  
J. Sova ◽  
Č. Vrba
Keyword(s):  
Local Anaesthetic ◽  
Local Anaesthetic Effect ◽  
Derivatives Of ◽  
Anaesthetic Effect

scholarly journals LOCAL ANAESTHETIC EFFECT OF OXYFEDRIN IN ANIMALS

1973 ◽  
Vol 45 (10) ◽  
pp. 1022-1028 ◽  
Author(s):  
F.W. EICHBAUM ◽  
W.J. YASAKA
Keyword(s):  
Local Anaesthetic ◽  
Local Anaesthetic Effect ◽  
Anaesthetic Effect

PHENAZONE POTENTIATES THE LOCAL ANAESTHETIC EFFECT OF LIDOCAINE IN MICE

2000 ◽  
Vol 41 (5) ◽  
pp. 539-542 ◽  
Author(s):  
MARC VERLEYE ◽  
ISABELLE HEULARD ◽  
JEAN-MARIE GILLARDIN
Keyword(s):  
Local Anaesthetic ◽  
Local Anaesthetic Effect ◽  
Anaesthetic Effect

The role of electrostatic interactions in modulating the local anaesthetic effects of amphipathic agents in frog skeletal muscle

1984 ◽  
Vol 62 (4) ◽  
pp. 350-355
Author(s):  
James G. Foulks ◽  
Lillian Morishita
Keyword(s):  
Local Anaesthetic ◽  
Electrostatic Interactions ◽  
Calcium Concentration ◽  
Specific Interaction ◽  
Frog Skeletal Muscle ◽  
Secondary Effects ◽  
Local Anaesthetic Effect ◽  
Selective Enhancement ◽  
Anaesthetic Effect

The local anaesthetic effect of cationic, anionic, and neutral alkyl amphipathic agents was similarly enhanced in an apparently nonspecific way by circumstances which modulate electrostatic interactions (acidity, modification of charged groups at the sarcolemmal surface by group-specific reagents, or changes in the calcium concentration), presumably as the result of secondary effects on the conformation of membrane proteins. However, the selective enhancement of the local anaesthetic effect of alkyl trimethylammonium compounds by perchlorate implies a more specific interaction which may influence the penetration of hydrophobic groups into the membrane interior.

On the local anaesthetic effect of barbiturates

1969 ◽  
Vol 21 (11) ◽  
pp. 763-768 ◽  
Author(s):  
P. KRUPP ◽  
C. P. BIANCHI ◽  
G. SUAREZ-KURTZ
Keyword(s):  
Local Anaesthetic ◽  
Local Anaesthetic Effect ◽  
Anaesthetic Effect
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