‘Compensatory’ muscle hypertrophy in the rat induced by tenotomy of synergistic muscles

1971 ◽  
Vol 27 (9) ◽  
pp. 1039-1040 ◽  
Author(s):  
Eva Macková ◽  
P. Hník
Keyword(s):  
Muscle Hypertrophy ◽  
Synergistic Muscles ◽  
Compensatory Muscle Hypertrophy

No effect of sex steroids on compensatory muscle hypertrophy

1984 ◽  
Vol 56 (6) ◽  
pp. 1589-1593 ◽  
Author(s):  
S. R. Max ◽  
N. E. Rance
Keyword(s):  
Androgen Receptor ◽  
Sex Steroids ◽  
Muscle Hypertrophy ◽  
Specific Activity ◽  
Oxidative Capacity ◽  
Muscle Weight ◽  
Hormone Status ◽  
14Co2 Production ◽  
Synergistic Muscles ◽  
Compensatory Muscle Hypertrophy

We studied the effects of sex steroids on muscle weight and oxidative capacity of rat plantaris muscles subjected to functional overload by removal of synergistic muscles. Eight weeks after bilateral synergist removal, plantaris muscles were strikingly hypertrophic compared with unoperated controls. After this period, there were selective alterations in the ability of the muscles to oxidize three substrates of oxidative metabolism. Thus 14CO2 production from [6-14C]glucose and [2-14C]pyruvate was significantly reduced, whereas there was no alteration in 14CO2 production from beta-[3-14C]hydroxybutyrate. Succinate dehydrogenase specific activity was decreased in overloaded muscle. There was no effect of sex hormone status on any of these parameters. Finally, 30 days of functional overload did not influence cytosolic androgen receptor binding. These results are not consistent with the idea that sex steroids and functional overload act synergistically.

The fate of newly formed satellite cells during compensatory muscle hypertrophy

1976 ◽  
Vol 21 (1) ◽  
pp. 113-118
Author(s):  
S. Schiaffino ◽  
S. Pierobon Bormioli ◽  
M. Aloisi
Keyword(s):  
Satellite Cells ◽  
Muscle Hypertrophy ◽  
Compensatory Muscle Hypertrophy

scholarly journals Loss of nNOS inhibits compensatory muscle hypertrophy and exacerbates inflammation and eccentric contraction-induced damage in mdx mice

2014 ◽  
Vol 24 (2) ◽  
pp. 492-505 ◽  
Author(s):  
S. C. Froehner ◽  
S. M. Reed ◽  
K. N. Anderson ◽  
P. L. Huang ◽  
J. M. Percival
Keyword(s):  
Muscle Hypertrophy ◽  
Eccentric Contraction ◽  
Mdx Mice ◽  
Compensatory Muscle Hypertrophy

Modulation of IGF mRNA abundance during stretch-induced skeletal muscle hypertrophy and regression

1994 ◽  
Vol 76 (5) ◽  
pp. 2026-2030 ◽  
Author(s):  
S. M. Czerwinski ◽  
J. M. Martin ◽  
P. J. Bechtel
Keyword(s):  
Skeletal Muscle ◽  
Muscle Hypertrophy ◽  
Muscle Protein ◽  
Muscle Growth ◽  
Mrna Abundance ◽  
Mrna Levels ◽  
Muscle Weight ◽  
Igf I ◽  
Compensatory Muscle Hypertrophy ◽  
First Time

Increased load on a muscle (synergistic overload or stretch) results in muscle hypertrophy. The expression of insulin-like growth factor I (IGF-I) mRNA in rat skeletal muscle is increased during synergistic overload-induced hypertrophy. Although it has also been established that fasting animals lose muscle protein, it has been shown that compensatory muscle hypertrophy occurs in adult fasting rats that are undergoing a net loss of body weight. The purpose of this investigation was to determine whether a relationship exists between IGF-I mRNA levels and muscle growth and regression. This was accomplished by examining whether IGF-I mRNA levels were altered during muscle hypertrophy after stretch and regression and the effect of fasting on IGF-I mRNA levels during stretch-induced hypertrophy. Patagialis (PAT) muscle weights increased 13 and 44% at 2 and 11 days of stretch, respectively. However, after removal of the stretch stimulus on day 11, PAT weights began to decrease, reaching control weights by 18 days. During the first time point (2 days), PAT muscle IGF-I mRNA remained constant. IGF-I mRNA abundance was threefold greater than contralateral control levels by 11 days of stretch. IGF-I mRNA levels decreased but remained significantly above control levels throughout the regression of hypertrophy (13, 18, and 25 days). Fasting did not alter PAT muscle response to stretch. After 11 days of stretch, PAT muscle weight increased 60% compared with contralateral control muscles and IGF-I mRNA levels increased three-fold. This study supports a role for IGF-I in muscle hypertrophy but not muscle atrophy.

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