Group B streptococcal polysaccharide detection in the urine of neonates by staphylococcal co-agglutination

1986 ◽  
Vol 175 (5) ◽  
pp. 293-298
Author(s):  
K. Bromberg ◽  
N. Feld ◽  
Y. Zheng
Keyword(s):  
Streptococcal Polysaccharide ◽  
Group B

scholarly journals Doubly Branched Hexasaccharide Epitope on the Cell Wall Polysaccharide of Group A Streptococci Recognized by Human and Rabbit Antisera

2005 ◽  
Vol 73 (10) ◽  
pp. 6383-6389 ◽  
Author(s):  
Francis Michon ◽  
Samuel L. Moore ◽  
John Kim ◽  
Milan S. Blake ◽  
France-Isabelle Auzanneau ◽  
...  
Keyword(s):  
Cell Wall ◽  
Rabbit Antiserum ◽  
Cell Wall Polysaccharide ◽  
Group A Streptococci ◽  
Group B Streptococci ◽  
Group A ◽  
Streptococcal Polysaccharide ◽  
Synthetic Oligosaccharides ◽  
Group B ◽  
Dominant Epitope

ABSTRACT A number of epitope specificities associated with the cell wall polysaccharide antigen of group A streptococci were identified in a polyclonal rabbit antiserum induced in rabbits by whole group A streptococci and in polyclonal convalescent human antisera from children that had recovered from streptococcal A infections. The identification was achieved by using a series of synthetic oligosaccharides, glycoconjugates, and bacterial polysaccharide inhibitors to inhibit the binding of the group A helical polysaccharide to the polyclonal antisera. The exclusively dominant epitope expressed in the convalescent human antisera was the doubly branched extended helical hexasaccharide with the structure α-l-Rhap(1→2)[β-d-GlcpNAc(1→3)]α-l-Rhap(1→3)α-l-Rhap(1→2)[β-d-GlcpNAc(1→3)]α-l-Rhap. The hexasaccharide epitope also bound with the highest immunoreactivity to the rabbit antiserum. In contrast, the human antisera did not show significant binding to the singly branched pentasaccharide with the structure α-l-Rhap(1→2)α-l-Rhap(1→3)α-l-Rhap(1→2)[β-d-GlcpNAc(1→3)]α-l-Rhap or the branched trisaccharide α-l-Rhap(1→2)[β-d-GlcpNAc(1→3)]α-l-Rhap, although both these haptens bound significantly to the same rabbit antiserum, albeit with less immunoreactivity than the hexasaccharide. Inhibition studies using streptococcal group A and B rabbit antisera and the inhibitors indicated above also suggested that the group A carbohydrate, unlike the group B streptococcal polysaccharide, does not contain the disaccharide α-l-Rhap(1→2)α-l-Rhap motif at its nonreducing chain terminus, stressing the importance of mapping the determinant specificities of these two important streptococcal subcapsular group polysaccharides to fully understand the serological relationships between group A and group B streptococci.

scholarly journals Maternal Antibody Transfer in Baboons and Mice Vaccinated with a Group B Streptococcal Polysaccharide Conjugate

2000 ◽  
Vol 181 (2) ◽  
pp. 653-658 ◽  
Author(s):  
Lawrence C. Paoletti ◽  
Julieanne Pinel ◽  
Ronald C. Kennedy ◽  
Dennis L. Kasper
Keyword(s):  
Maternal Antibody ◽  
Streptococcal Polysaccharide ◽  
Group B

Dose–response to type V group B streptococcal polysaccharide–tetanus toxoid conjugate vaccine in healthy adults

Vaccine ◽  
2007 ◽  
Vol 25 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Carol J. Baker ◽  
Marcia A. Rench ◽  
Lawrence C. Paoletti ◽  
Morven S. Edwards
Keyword(s):  
Conjugate Vaccine ◽  
Dose Response ◽  
Tetanus Toxoid ◽  
Healthy Adults ◽  
Streptococcal Polysaccharide ◽  
Group B ◽  
Type V

scholarly journals Quantitative Determination of Antibodies to Type III Group B Streptococcal Polysaccharide

1996 ◽  
Vol 173 (1) ◽  
pp. 142-150 ◽  
Author(s):  
Hilde-Kari Guttormsen ◽  
Carol J. Baker ◽  
Morven S. Edwards ◽  
Lawrence C. Paoletti ◽  
Dennis L. Kasper
Keyword(s):  
Quantitative Determination ◽  
Type Iii ◽  
Streptococcal Polysaccharide ◽  
Group B

Safety and immunogenicity of a tetravalent group B streptococcal polysaccharide vaccine in healthy adults

Vaccine ◽  
1996 ◽  
Vol 14 (5) ◽  
pp. 446-450 ◽  
Author(s):  
Karen L. Kotloff ◽  
Ali Fattom ◽  
Lisa Basham ◽  
Abbas Hawwari ◽  
Scott Harkonen ◽  
...  
Keyword(s):  
Polysaccharide Vaccine ◽  
Healthy Adults ◽  
Streptococcal Polysaccharide ◽  
Group B

Antibodies to Type III Group B Streptococcal Polysaccharide in Breast Milk

2004 ◽  
Vol 23 (10) ◽  
pp. 961-963 ◽  
Author(s):  
Morven S. Edwards ◽  
Flor M. Munoz ◽  
Carol J. Baker
Keyword(s):  
Breast Milk ◽  
Type Iii ◽  
Streptococcal Polysaccharide ◽  
Group B
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