Blood platelet cyclic AMP during long-term treatment of premature labor

1980 ◽  
Vol 230 (1) ◽  
pp. 89-94 ◽  
Author(s):  
R. Göser ◽  
R. C. Briel ◽  
G. Breisch ◽  
K. Jaschonek ◽  
A. E. Schindler
Keyword(s):  
Cyclic Amp ◽  
Blood Platelet ◽  
Term Treatment ◽  
Premature Labor ◽  
Long Term Treatment

Prolonged Plasma Clotting Time and Decreased Fibrinolysis after Long Term Treatment with α-Tocopherol

1974 ◽  
Vol 31 (03) ◽  
pp. 505-512 ◽  
Author(s):  
K Korsan-Bengtsen ◽  
D Elmfeldt ◽  
T Holm
Keyword(s):  
Fibrinolytic Activity ◽  
Blood Platelet ◽  
Term Treatment ◽  
Clotting Time ◽  
Platelet Factor ◽  
Membrane Function ◽  
Significant Prolongation ◽  
Activity Factor ◽  
Long Term Treatment

SummaryBlood platelet function, blood clotting and fibrinolysis were studied in a group of 9 male post myocardial infarction patients once a week for 5 consecutive weeks after which α-tocopherol 300 mg/day was given. The group was again investigated after 2, 6, 18, 44 and 64 weeks of α-tocopherol treatment. After 18, 44 and 64 weeks of treatment a highly significant prolongation of the plasma clotting time was observed. On the basis of the analyses made it is concluded that the prolongation is probably due to a decreased platelet factor 3 activity. The ability to increase fibrinolytic activity after stasis of the arm is reduced after long term α-tocopherol treatment. There were no changes in the number of platelets, platelet adhesiveness, factor II-VII-X activity, factor VIII, fibrinogen, antithrombin III, α1-antitrypsin, α2-macroglobulin, total anti-fibrinolytic activity or plasminogen. Our hypothesis to explain the results is that α-tocopherol influences on the cell membranes of the platelets and the endothelial cells and thus causes a reduced release of platelet factor 3 and activators of fibrinolysis. This is in line with many other observations indicating that α-tocopherol is of importance for the cell membrane function.

Hypnotherapy is effective in the long-term treatment of functional dyspepsia

2001 ◽  
Vol 120 (5) ◽  
pp. A115-A115 ◽  
Author(s):  
E CALVERT ◽  
L HOUGHTON ◽  
P COOPER ◽  
P WHORWELL
Keyword(s):  
Functional Dyspepsia ◽  
Term Treatment ◽  
Long Term Treatment

1608: Long-Term Treatment with High Doses of Sildenafil Does Not Up-Regulate the Levels of Phosphodiesterase 5 (Pde5) in the Rat Penis

2004 ◽  
Vol 171 (4S) ◽  
pp. 424-424 ◽  
Author(s):  
Monica G. Ferrini ◽  
Eliane G. Valente ◽  
Jacob Rajfer ◽  
Nestor F. Gonzalez-Cadavid
Keyword(s):  
Term Treatment ◽  
Long Term Treatment ◽  
High Doses ◽  
Phosphodiesterase 5

Long-Term Treatment Outcomes for Heroin Dependence: The 11-Year Follow-Up of the ATOS Study

2013 ◽  
Author(s):  
Christina Marel ◽  
Maree Teesson ◽  
Shane Darke ◽  
Katherine Mills ◽  
Joanne Ross ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Term Treatment ◽  
Heroin Dependence ◽  
Long Term Treatment
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