Panhypopituitarism without diabetes insipidus: Magnetic resonance imaging of pituitary stalk transection

1990 ◽  
Vol 149 (4) ◽  
pp. 235-236 ◽  
Author(s):  
C. Christophe ◽  
G. Van Vliet ◽  
G. Dooms ◽  
M. Lemort ◽  
N. Perlmutter ◽  
...  
1998 ◽  
Vol 139 (6) ◽  
pp. 635-640 ◽  
Author(s):  
M Maghnie ◽  
E Genovese ◽  
MG Sommaruga ◽  
M Arico ◽  
D Locatelli ◽  
...  

We report on a 15-year-old girl who had presented with acute onset central diabetes insipidus at the age of 8 years; this was followed by growth failure due to acquired growth hormone deficiency. Initial magnetic resonance imaging showed a uniformly enlarged pituitary stalk and absence of posterior pituitary hyperintensity. Frequent patient examination and magnetic resonance imaging gave unchanged results until after 5 years a large hypothalamic mass and panhypopituitarism were found. Dynamic magnetic resonance imaging documented hypothalamic-pituitary vasculopathy. Histopathological examination revealed perivascular inflammatory lymphoplasmic infiltrates with no granulomatosis or necrosis and negative staining for S-100 protein, suggesting autoimmune inflammatory disease (lymphocytic infundibuloneurohypophysitis?). The response to glucocorticoid pulses (30 mg/kg per day for 3 days i.v.) was favorable. the hypothalamic mass being halved and partial anterior pituitary function recovery maintained for 2 years after the start of treatment. We suggest that long-term surveillance is needed for isolated and chronic thickening of the pituitary stalk and that dynamic magnetic resonance imaging can contribute to the demonstration of hypothalamic-pituitary vascular impairment associated with local vasculitis.


2017 ◽  
Vol 47 (5) ◽  
pp. 599-605 ◽  
Author(s):  
Imane El Sanharawi ◽  
Loukia Tzarouchi ◽  
Liesbeth Cardoen ◽  
Laetitia Martinerie ◽  
Juliane Leger ◽  
...  

1998 ◽  
Vol 84 (1) ◽  
pp. 85-86
Author(s):  
Mark A. Marinella

The case of a previously healthy 63-year-old female with metastatic adenocarcinoma to the hypothalamus presenting with central diabetes insipidus is presented. The patient was found to have metastatic disease isolated to her hypothalamus on brain magnetic resonance imaging as well as a water deprivation test consistent with central diabetes insipidus. The patient had a decrease in symptoms of polyuria and polydypsia as well as a decrease in urine volumes after treatment with intranasal vasopressin. Even though a rare occurrence, physicians should consider metastatic adenocarcinoma in patients with recent-onset polyuria and polydypsia.


The Lancet ◽  
1989 ◽  
Vol 333 (8643) ◽  
pp. 901 ◽  
Author(s):  
G. Chiumello ◽  
B. Di Natale ◽  
C. Pellini ◽  
A. Beneggi ◽  
G. Scotti ◽  
...  

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