Colorectal cancer: The relationship of staging to survival A cancer registry study of 800 cases in St. Gallen-Appenzell

1986 ◽  
Vol 31 (2) ◽  
pp. 85-88 ◽  
Author(s):  
F. Enderlin ◽  
F. Gloor
Keyword(s):  
Colorectal Cancer ◽  
Cancer Registry ◽  
Registry Study ◽  
Relationship Of ◽  
The Relationship

SMAD2 and the relationship of colorectal cancer to inflammatory bowel disease

2008 ◽  
Vol 23 (3) ◽  
pp. 169-175 ◽  
Author(s):  
S.S. Mahid ◽  
K.S. Minor ◽  
B.C. Brangers ◽  
G.A. Cobbs ◽  
S. Galandiuk
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Relationship Of ◽  
The Relationship

The impact of sidedness of colorectal cancer in tumor immunity.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 584-584
Author(s):  
Masaaki Nishi ◽  
Mitsuo Shimada ◽  
Hideya Kashihara ◽  
Jun Higashijima ◽  
Kozo Yoshikawa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Tumor Immunity ◽  
Poor Prognosis ◽  
Molecular Characteristics ◽  
Clinicopathological Factors ◽  
Significant Difference ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

584 Background: Clinical and molecular characteristics are different between Right-side and left-sided colorectal cancer (CRC). The aim of this study was to clarify the significance of the correlation of the Sidedness of CRC and tumor immunity. Methods: A total of 116 patients who underwent curative colectomy for stage II/III CRC were included in this study. The expression of PD-1, PD-L1, FoxP3, TGF-b, and IDO was examined by immunohistochemistry and the relationship of sidedness to several prognostic factors was examined. Results: In clinicopathological factors, there were no significant difference between right sided and left sided CRC except for differentiation. Regarding tumor immunity, there were no significant difference in PD-1 and IDO expression. However, Fox P3 (right side 72% vs. left side 59%) and TGFβ (right side 72% vs. left side 57%) tended to be highly expressed in right side(p < 0.1). PDL1 was significantly highly expressed in right side(right side 65% vs. left side 35%, p < 0.05). In OS and DFS, the patients with right sided tumor tended to have poor prognosis compared with left side (p < 0.1). The PD-L1 positive patients of right-sided tumor had poor prognosis (p < 0.05). Conclusions: Sidedness is associated with tumor immunity in colorectal cancer.

scholarly journals Neuroendocrine Differentiation in Sporadic CRC and Hereditary Nonpolyosis Colorectal Cancer

2004 ◽  
Vol 20 (4-5) ◽  
pp. 283-288 ◽  
Author(s):  
M. H. Sun
Keyword(s):  
Colorectal Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Neuroendocrine Differentiation ◽  
Neuroendocrine Cells ◽  
Human Neoplasm ◽  
Hereditary Nonpolyposis ◽  
Sporadic Colorectal Carcinoma ◽  
Colon And Rectum ◽  
Relationship Of ◽  
The Relationship

Extent neuroendocrine differentiation can be encountered in many human neoplasm derived from different organs and systems using immunohistochemistry and ultrastructural techniques. The tumor cells' behaviors resemble those of neurons and neuroendocrine cells. The presence of neuroendocrine differentiation reputedly appears to be associated with a poorer prognosis than the adenocarcinoma counterparts in sporadic human neoplasm. In this review the neuroendocrine carcinoma and the adenocarcinoma with neuroendocrine differentiation of colon and rectum both in sporadic colorectal carcinoma and the hereditary nonpolyposis colorectal cancer, the relationship of neuroendocrine differentiation and some possible molecular pathways in tumorogenesis of colorectal cancer will be discussed. Possible treatment strategy will also be addressed.

scholarly journals Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study

2019 ◽  
Vol 16 (20) ◽  
pp. 3915 ◽  
Author(s):  
Ausvydas Patasius ◽  
Vincas Urbonas ◽  
Giedre Smailyte
Keyword(s):  
Prostate Cancer ◽  
General Population ◽  
Cancer Registry ◽  
Registry Study ◽  
Skin Melanoma ◽  
Expected Number ◽  
Melanoma Diagnosis ◽  
Increased Risk ◽  
The Relationship ◽  
Subsequent Risk

Emerging data indicates that melanoma may be linked to prostate cancer. We evaluated if the incidence of melanoma was associated with subsequent risk of prostate cancer (PC). We extracted data from the Lithuanian cancer registry from 1993 to 2012. We calculated the standardized incidence ratios (SIRs) for PC as a ratio of observed number of cancer cases in people with previous melanoma diagnosis to the expected number of cancer cases in the underlying general population. Therein, 95% confidence intervals for the SIRs were estimated assuming the number of observed cancer cases follows the Poisson distribution. Overall, 65 PCs were observed versus 52.5 expected (SIR 1.24; 95% CI: 0.97–1.58) within a period of 24 years. A significantly increased risk of PC was found in patients with melanoma diagnosis over 70 years (SIR 1.62; 95% CI: 1.11–2.39) and in two periods of diagnosis (SIRs 1.76 and 1.62 in 1993–1997 and 2009–2012, respectively). A significantly increased risk was also found five to nine years after melanoma diagnosis (SIR 1.58; 95% CI: 1.05–2.38). Further studies are needed to evaluate the relationship between melanoma and subsequent risk of prostate cancer.

Experimental colorectal cancer: The relationship of diet and faecal bile acid concentration to tumour induction

1986 ◽  
Vol 73 (3) ◽  
pp. 233-237 ◽  
Author(s):  
D. J. Galloway ◽  
R. W. Owen ◽  
Freda Jarrett ◽  
P. Boyle ◽  
M. J. Hill ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bile Acid ◽  
Acid Concentration ◽  
Bile Acid Concentration ◽  
Tumour Induction ◽  
Relationship Of ◽  
The Relationship

scholarly journals Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

2021 ◽  
Author(s):  
Sandeep Appunni ◽  
Muni Rubens ◽  
Venkataraghavan Ramamoorthy ◽  
Anshul Saxena ◽  
Raees Tonse ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiome ◽  
Colonic Mucosa ◽  
Fusobacterium Nucleatum ◽  
Dietary Factors ◽  
Lifestyle Modifications ◽  
Related Factors ◽  
Molecular Events ◽  
Relationship Of ◽  
The Relationship

Dietary factors play an important role in shaping the gut microbiome which, in turn, regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome have been implicated in the development of colorectal cancer (CRC). Diets low in dietary fibers and phytomolecules as well as other lifestyle-related factors may predispose to CRC. Emerging evidence demonstrates that the predominance of microbes, such as Fusobacterium nucleatum, can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. In this study, we aim to present evidence regarding the relationship of dietary factors to the gut microbiome and development of CRC.

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