Amino acid derivatives of 5-ASA as novel prodrugs for intestinal drug delivery

1994 ◽  
Vol 39 (12) ◽  
pp. 2601-2606 ◽  
Author(s):  
Carlo Clerici ◽  
Giorgio Gentili ◽  
Enrico Boschetti ◽  
Carla Santucci ◽  
Aaron Garzon Aburbeh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Derivatives Of

Amino acid derivatives of UDCA as novel prodrugs for colon-specific drug delivery

2000 ◽  
Vol 118 (4) ◽  
pp. A517
Author(s):  
Carlo Clerici ◽  
Roberto Pellicciari ◽  
Kenneth Setchell ◽  
Nancy O'Connel ◽  
Giorgio Gentili ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Specific Drug ◽  
Colon Specific Drug Delivery ◽  
Derivatives Of

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

scholarly journals Novel Amino Acid Derivatives of Quinolines as Potential Antibacterial and Fluorophore Agents

2020 ◽  
Vol 88 (4) ◽  
pp. 57
Author(s):  
Oussama Moussaoui ◽  
Rajendra Bhadane ◽  
Riham Sghyar ◽  
El Mestafa El Hadrami ◽  
Soukaina El Amrani ◽  
...  
Keyword(s):  
Amino Acid ◽  
Methyl Esters ◽  
Amino Acid Derivatives ◽  
Bacterial Strains ◽  
Fluorescent Properties ◽  
Topoisomerase Iv ◽  
Microdilution Method ◽  
Hydrolysis Of ◽  
Derivatives Of

A new series of amino acid derivatives of quinolines was synthesized through the hydrolysis of amino acid methyl esters of quinoline carboxamides with alkali hydroxide. The compounds were purified on silica gel by column chromatography and further characterized by TLC, NMR and ESI-TOF mass spectrometry. All compounds were screened for in vitro antimicrobial activity against different bacterial strains using the microdilution method. Most of the synthesized amino acid-quinolines show more potent or equipotent inhibitory action against the tested bacteria than their correspond esters. In addition, many of them exhibit fluorescent properties and could possibly be utilized as fluorophores. Molecular docking and simulation studies of the compounds at putative bacterial target enzymes suggest that the antimicrobial potency of these synthesized analogues could be due to enzyme inhibition via their favorable binding at the fluoroquinolone binding site at the GyrA subunit of DNA gyrase and/or the ParC subunit of topoisomerase-IV.

Synthesis of Some Amino Acid Derivatives of Styrene1

1959 ◽  
Vol 81 (2) ◽  
pp. 377-382 ◽  
Author(s):  
L. R. Morris ◽  
R. A. Mock ◽  
C. A. Marshall ◽  
J. H. Howe
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Derivatives Of

Synthesis of amino acid derivatives of indole-3-acetic acid

2005 ◽  
Vol 2005 (10) ◽  
pp. 640-642 ◽  
Author(s):  
Ying Liu ◽  
Liang Zhao ◽  
Liang Liu ◽  
Lin-Yi Wei ◽  
Lu-Hua Lai
Keyword(s):  
Acetic Acid ◽  
Amino Acid ◽  
Amino Acid Derivatives ◽  
H Nmr ◽  
Derivatives Of ◽  
Indole 3 Acetic Acid

Amino acid derivatives of a modified indole-3-acetic acid have been synthesised. Fourteen new dipeptide-like compounds 3–4 were obtained and their structures were elucidated based on the IR, 1H NMR, MS spectra.

Synthesis of amino acid derivatives of benzofuroxan

2013 ◽  
Vol 450 (2) ◽  
pp. 149-151 ◽  
Author(s):  
I. V. Serkov ◽  
E. A. Chugunova ◽  
A. R. Burilov ◽  
S. O. Bachurin
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Derivatives Of

scholarly journals Synthesis of New 6,7(N,O)-Heterocyclic 1,4-Naphthoquinones

2021 ◽  
Vol 11 (6) ◽  
pp. 13903-13910
Keyword(s):  
Amino Acid ◽  
High Activity ◽  
Biologically Active ◽  
Amino Acid Derivatives ◽  
Antimicrobial Substances ◽  
Derivatives Of

As a result of the carried out research it was synthesized an order of new potentially biologically active modified N-,O-contained heterocycles on the base of amino acid derivatives of 2,6,7-nitrogen substituted-3-chloro-1,4-naphthoquinone. It was established that among synthesized compounds, there are potential antimicrobial substances with high activity.

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