Mixed lymphocyte cultures (MLC) and acute pancreatitis after renal transplantation

1981 ◽  
Vol 13 (4) ◽  
pp. 391-394 ◽  
Author(s):  
J. Járay ◽  
F. Perner ◽  
F. Alföldy ◽  
K. Onody
Keyword(s):  
Acute Pancreatitis ◽  
Renal Transplantation ◽  
Lymphocyte Cultures ◽  
Mixed Lymphocyte Cultures

Effect of Donor-Specific Transfusions on Renal Transplantation in Children

PEDIATRICS ◽  
1985 ◽  
Vol 76 (3) ◽  
pp. 402-405
Author(s):  
Donald Potter ◽  
Marvin Garovoy ◽  
Susan Hopper ◽  
Paul Terasaki ◽  
Oscar Salvatierra
Keyword(s):  
Renal Transplantation ◽  
Blood Donors ◽  
Mixed Lymphocyte Culture ◽  
High Reactivity ◽  
Lymphocyte Culture ◽  
Blood Transfusions ◽  
Lymphocyte Cultures ◽  
Mixed Lymphocyte Cultures ◽  
Related Donor ◽  
The Difference

Most family members who are evaluated as kidney donors for children have high reactivity in a mixed lymphocyte culture test and are thus excluded from donation. Fifty children, most of whom had highly reactive mixed lymphocyte cultures with their donors, were challenged with three blood transfusions from their donors before transplantation and were tested for the development of lymphocytotoxic antibodies. Ten children (20%) became sensitized and had a positive T-cell or B-cell crossmatch. Sensitization occurred less frequently in children treated with azathioprine during donor-specific transfusions (11%) than in those not treated (26%), but the difference was not significant. Thirty-seven children received renal transplants from their blood donors after the donor-specific transfusions. There were no deaths, and only two patients had kidney failure. Actuarial kidney survival was 93% after 6 years. The use of donor-specific transfusion has increased the number of related-donor transplants performed and the results have been highly successful.

CELLULAR AND HUMORAL FACTORS GOVERNING CANINE MIXED LYMPHOCYTE CULTURES AFTER RENAL TRANSPLANTATION

1971 ◽  
Vol 12 (1) ◽  
pp. 65-76 ◽  
Author(s):  
I Antibody ◽  
Joshua Miller ◽  
Brack Hattler ◽  
Minnie Davis ◽  
Merrill C. Johnson
Keyword(s):  
Renal Transplantation ◽  
Humoral Factors ◽  
Lymphocyte Cultures ◽  
Mixed Lymphocyte Cultures

scholarly journals QUANTITATIVE STUDIES ON THE MIXED LYMPHOCYTE INTERACTION IN RATS

1971 ◽  
Vol 134 (4) ◽  
pp. 857-870 ◽  
Author(s):  
Darcy B. Wilson ◽  
Dianne H. Fox
Keyword(s):  
Cell Surface ◽  
Surface Antigens ◽  
Mouse Cell ◽  
Cell Surface Antigens ◽  
Quantitative Studies ◽  
Lymphocyte Cultures ◽  
Mixed Lymphocyte Cultures ◽  
Environmental Antigens ◽  
Germfree Rats ◽  
Number Of Cells

The proliferative reactivity of lymphocytes from rat donors maintained under germfree or conventional conditions was examined in mixed lymphocyte cultures stimulated with allogeneic and xenogeneic cell surface antigens. The results show (a) that lymphocytes from conventionally maintained rats are less reactive to human, hamster, guinea pig, and mouse cell surface antigens than to the major H alloantigens, and (b) that lymphocytes from germfree rats display no demonstrable reactivity to xenogeneic cells, but are quantitatively normal in their response to allogenic cells. The conclusion drawn from these observations is that the circulating lymphocyte pool of an individual consists of a greater proportion of cells reactive to H alloantigens of other members of the same species than to the xenogeneic cellular antigens of members of other species and that this large number of cells is not generated by a mechanism involving immunization to cross-reactive environmental antigens.

Effect of Heparin on Mixed Lymphocyte Cultures

Nature ◽  
1967 ◽  
Vol 215 (5097) ◽  
pp. 164-165 ◽  
Author(s):  
G. A. CURRIE
Keyword(s):  
Lymphocyte Cultures ◽  
Mixed Lymphocyte Cultures

Mixed Lymphocyte Cultures with Inbred Individuals: An Approach to MLC Typing

2008 ◽  
Vol 3 (5) ◽  
pp. 323-339 ◽  
Author(s):  
F. Jørgensen ◽  
L. U. Lamm ◽  
F. Kissmeyer-nielsen
Keyword(s):  
Lymphocyte Cultures ◽  
Mixed Lymphocyte Cultures
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