Pancreatic growth and function following surgical treatment of nesidioblastosis in infancy

Оперативное лечение различных заболеваний кишечника сопровождается осложнениями в виде нарушений микроциркуляции в области анастомоза кишки. Ранее нами показана способность лимфостимуляторов пептидной природы восстанавливать нарушенную микроциркуляцию, что послужило основой для настоящего исследования. Цель работы - оценка влияния стимуляции лимфотока в стенке кишки на процессы восстановления микроциркуляции, структуры и функции тонкой кишки в области оперативного вмешательства. Методика. В экспериментах на наркотизированных крысах (хлоралгидрат в дозе 0,6 г/кг в 0,9% растворе NaCl) моделировали различные поражения тонкой кишки (наложение лигатуры, перевязка 1-3 брыжеечных артерий, перекрут петли кишки вокруг оси брыжейки, сочетание нескольких видов повреждений). Резекция поврежденного участка через 1 сут. с последующим созданием тонкокишечного анастомоза завершалась орошением операционного поля раствором пептида-стимулятора лимфотока (40 мкг/кг массы животного в 1 мл 0,9% раствора NaCl). На 7-е сут. после операции проводили гистологическое исследование фрагмента кишки в области анастомоза. Результаты. На 7-е сут. после резекции у выживших животных (летальность вследствие кишечной непроходимости составляла 30%) имеют место морфологические признаки острых сосудистых нарушений стенки кишки, изменений кровеносных и лимфатических микрососудов, интерстициальный отек всех слоев стенки кишки, дилатация просвета кишки, повреждение всасывающего эпителия ворсин с истончением щеточной каемки клеток, морфологические признаки гиперфункции бокаловидных клеток. Использование лимфостимулятора пептидной природы после операции увеличивало выживаемость животных на 24%. У части животных отмечалось уменьшение расширения просвета кишки, у других практически полная его нормализация. Восстанавливалась форма кишечных ворсин и распределение бокаловидных клеток. Отсутствовали признаки внутриклеточного и межмышечного отека. Отмечено умеренное полнокровие венул. Заключение. Использование лимфостимулятора при хирургическом лечении кишечной непроходимости увеличивает выживаемость животных на 24% по сравнению с контролем, способствует более раннему восстановлению структуры и функции тонкой кишки. Полученные результаты свидетельствуют о перспективности использования стимуляции лимфотока при операциях на кишечнике. Surgical treatment of bowel diseases is associated with complications that cause microcirculatory disturbances in the anastomosis area and may lead to a fatal outcome. This study was based on our previous finding that peptide-type lymphatic stimulators are able to restore impaired microcirculation. The aim of this work was stimulating the lymph flow in the intestinal wall to facilitate recovery of microcirculation, structure and function of the small intestine in the area of surgical intervention. Methods. In experiments on anesthetized rats (0.6 g/kg chloral hydrate in 0.9% NaCl), various small bowel lesions were modeled (bowel ligation, ligation of 1-3 mesenteric arteries, gut torsion, combination of several lesion types). In 24 h, the damaged area was resected, and a small intestine anastomosis was creased. The surgery was completed with irrigation of the operative field with a solution of lymph flow stimulating peptide (40 мg/kg body weight in 1 ml of 0.9% NaCl). A gut fragment from the anastomosis area was examined histologically on day 7 after the surgery. Results. On the 7th day after removing the intestinal obstruction, the surviving animals (lethality 30%) had morphological signs of acute vascular disorders in the intestinal wall; changes in blood and lymphatic microvessels; interstitial edema of all intestinal wall layers; dilatation of the intestinal lumen; damage to the absorptive epithelium of villi with thinning of the brush border, and hyperfunction of mucous (goblet) cells. The use of the peptide after surgery increased the survival rate of animals by 24% and provided a smaller dilatation of the intestinal lumen in some animals. In other animals, the lumen recovered. The shape of intestinal villi and distribution of goblet cells were restored. Signs of intracellular and intermuscular edema were absent. Moderate venular congestion was noticed. Conclusion. Using the lymphatic stimulator in surgical treatment of intestinal obstruction increases the survival rate of animals by 24% compared to the control, facilitates earlier restoration of the small intestine structure and function. The obtained results indicated the effectiveness of lymphatic stimulation in intestinal surgery.

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Outcomes Following Surgical Treatment of Hamate Arthrosis Lunotriquetral Ligament Injuries

Hand ◽

10.1177/15589447211043216 ◽

2021 ◽

pp. 155894472110432

Author(s):

Jesse Meaike ◽

Joshua Meaike ◽

Sanjeev Kakar

Keyword(s):

Surgical Treatment ◽

Treatment Group ◽

Combined Treatment ◽

Additional Treatment ◽

Ligament Injuries ◽

Interosseous Ligament ◽

Institutional Review ◽

Lunotriquetral Ligament ◽

Treatment Plans ◽

And Function

Background: An institutional review board–approved study of the functional outcomes of patients after surgical treatment of hamate arthrosis lunotriquetral ligament tear (HALT) lesions was conducted. Methods: In all, 21 wrists in 19 patients underwent arthroscopic, open, or combined treatment of HALT lesions. Seven patients underwent isolated hamate debridement and 14 had concomitant procedures to address lunotriquetral pathology. Nineteen wrists underwent procedures to address additional pathology, including triangular fibrocartilage complex, ulnotriquetral ligament split, and scapholunate ligament injuries. Results: Mayo wrist scores increased from 54 to 71. Sixteen patients had no or mild pain postoperatively, compared with none preoperatively. When stratified by lunotriquetral interosseous ligament management, 75% of the limited treatment group (none or debridement) and 78% of the additional treatment group reported improved pain. Three patients underwent additional surgeries for persistent pain. Conclusion: Resection of the proximal pole of the hamate can improve pain and function for patients with ulnar-sided wrist pain secondary to a HALT lesion. Concomitant wrist pathologies should be considered when determining treatment plans.

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The nose and sinuses

Oxford Handbook of ENT and Head and Neck Surgery ◽

10.1093/med/9780199550791.003.09 ◽

2009 ◽

pp. 159-184

Author(s):

Rogan Corbridge ◽

Nicholas Steventon

Keyword(s):

Surgical Treatment ◽

Medical Treatment ◽

Chronic Rhinosinusitis ◽

Nasal Polyps ◽

Chronic Sinusitis ◽

Structure And Function ◽

Acute Sinusitis ◽

And Function ◽

Nose And Sinuses

Structure and function of the nose 160 Rhinitis 164 Types of rhinitis 165 Medical treatment of rhinitis 166 Surgical treatment of rhinitis 168 Sinusitis 169 Acute sinusitis 170 Recurrent acute sinusitis 171 Chronic sinusitis 172 Surgery for chronic rhinosinusitis 174 Complications of sinusitis 176 Nasal polyps ...

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Some Points in the Diagnosis of Stone by X-Rays

Proceedings of the Royal Society of Medicine ◽

10.1177/003591573502800735 ◽

1935 ◽

Vol 28 (7) ◽

pp. 909-923

Author(s):

C. A. Wells

Keyword(s):

Urinary Tract ◽

Surgical Treatment ◽

X Rays ◽

Characteristic Shape ◽

Positive Diagnosis ◽

Opaque Material ◽

Operative Removal ◽

And Function

The investigation of cases suspected of stone is concerned with (1) those in which a shadow is visible and (2) those in which X-rays throw no shadow. In the former group the nature of the shadow must be determined. If a stone, it must be accurately placed in the urinary tract and the anatomy and function of the affected and unaffected parts of the tract must be determined. A stone may be recognized by the characteristic shape to which it grows in the pelvis, in a calyx or in the ureter. In the earlier stages, or when the shape of the shadow is not characteristic, radiograms may be made on inspiration and expiration. In orthopædic and other cases immobilized for long periods interesting calculi may form and may subsequently be disintegrated and passed, or may require surgical treatment. For stones in the kidney and upper ureter pyelography by the descending route is ideal. For infected stones the retrograde route is preferable. For small ureteric stones an opaque catheter is best. Non-opaque stones are of real surgical significance. It is essential to make a positive diagnosis in a case of suspected stone, even if operation is not required. Furthermore, non-opaque stones are sometimes sufficiently large to demand operative removal. The presence of these stones can be inferred from descending pyelograms, and the stones themselves can be displayed by means of the opaque material they pick up in the course of a descending pyelography.

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A Prospective Cohort-Study on the Return to Work and Function Two Years After Surgical Treatment of Tibiotalar Arthritis

Foot & Ankle Orthopaedics ◽

10.1177/2473011416s00118 ◽

2016 ◽

Vol 1 (1) ◽

pp. 2473011416S0011

Author(s):

Alastair S. Younger ◽

Andrea Veljkovic ◽

Kevin Wing ◽

Murray J. Penner ◽

Oliver Gagné

Keyword(s):

Cohort Study ◽

Surgical Treatment ◽

Return To Work ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

And Function

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THORACOLUMBAR BURST FRACTURE: CORRELATION BETWEEN KYPHOSIS AND FUNCTION AFTER SURGICAL TREATMENT

Revista Brasileira de Ortopedia (English Edition) ◽

10.1016/s2255-4971(15)30131-2 ◽

2012 ◽

Vol 47 (4) ◽

pp. 474-478

Author(s):

Daniel Akira Sadatsune ◽

Pedro Pereira da Costa ◽

Maria Fernanda Silber Caffaro ◽

Ricardo Shigueaki Umeta ◽

Robert Meves ◽

...

Keyword(s):

Surgical Treatment ◽

Burst Fracture ◽

Thoracolumbar Burst Fracture ◽

And Function

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Thyroid morphology and function after surgical treatment of thyroid diseases

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0029-1211453 ◽

2009 ◽

Vol 104 (03) ◽

pp. 271-277 ◽

Cited By ~ 11

Author(s):

B. Mann ◽

P. Schmale ◽

W. Stremmel

Keyword(s):

Surgical Treatment ◽

Thyroid Diseases ◽

Thyroid Morphology ◽

And Function

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Significance of Perinatal Anamnesis for Determination of Treatment Plan and Subsequent Neurological Prognosis for Children with Anomaly Chiari 1

Journal of New Medical Technologies ◽

10.12737/4998 ◽

2014 ◽

Vol 21 (2) ◽

pp. 54-57

Author(s):

Козлитина ◽

T. Kozlitina ◽

Глаголев ◽

Nikolay Glagolev

Keyword(s):

Cervical Spine ◽

Surgical Treatment ◽

Soft Tissues ◽

Treatment Plan ◽

Neurological Status ◽

Pathological Process ◽

Spine Injury ◽

Normal Birth ◽

And Function ◽

Conservative And Surgical Treatment

The injuries of the cervical spine injury craniovertebral transition, involving in pathological process of vertebral arteries or the spinal cord can cause obstetric benefits as pathological and normal birth. In this article the authors evaluate the effects generic posttraumatic changes soft tissues of the cervical spine in the development of vascular disorders in the field craniovertebral transition. For this study, 112 patients with Chiari anomaly 1, received conservative and surgical treatment, were ex-amined. Children from 2 to 18 years were divided into two groups: the 1st group - children (55 patients) without surgical treatment, and the 2nd group of children after decompressive trepanation about Chiari anomaly 1. Common neurological status, anatomy and function of blood vessels at the level craniovertebral transition were assessed in all children. Perinatal anamnesis, including: cesarean section, rapid delivery, entanglement neck child´s umbilical cord, and use of obstetric benefits in the form of application of forceps and receive «squeezing», was studied. Changes in the normal course of delivery, pointing to birth trauma level craniovertebral transition were noted in 96 patients (85,7%). This fact may have prognostic value in the treatment and follow-up care of children with Chiari anomaly 1.

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