Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding

1990 ◽  
Vol 150 (2) ◽  
pp. 136-138 ◽  
Author(s):  
B. Frey ◽  
G. Schubiger ◽  
J. P. Musy
Keyword(s):  
Breast Feeding ◽  
Cholestatic Hepatitis ◽  
Exposure During Pregnancy

Neonatal Cholestatic Hepatitis from Carbamazepine Exposure during Pregnancy and Breast Feeding

2002 ◽  
Vol 36 (4) ◽  
pp. 644-647 ◽  
Author(s):  
Bernhard Frey ◽  
Christian P Braegger ◽  
Daniela Ghelfi
Keyword(s):  
Breast Feeding ◽  
Liver Dysfunction ◽  
Product Information ◽  
Case Reports ◽  
Diagnostic Procedures ◽  
Cholestatic Hepatitis ◽  
Case Summary ◽  
Epileptic Mother ◽  
Exposure During Pregnancy ◽  
Second Period

OBJECTIVE: To report a case of transient cholestatic hepatitis occurring in an infant between the third and seventh weeks of life, most likely due to carbamazepine exposure during pregnancy and breast feeding. CASE SUMMARY: A boy, born to an epileptic mother who had been treated with carbamazepine monotherapy throughout pregnancy and breast feeding, experienced asphyxia at birth with transient hepatic dysfunction in the first week of life. After full recovery from asphyxia, he experienced a second period of liver dysfunction, presenting as cholestatic hepatitis that lasted approximately 5 weeks. Infectious and metabolic etiologies as well as extrahepatic biliary atresia were excluded. DISCUSSION: Carbamazepine is known to induce hepatic damage in children and adults. As the drug crosses the placenta and is excreted into breast milk, infants of mothers taking carbamazepine might also develop liver dysfunction. In addition to the present case, there are 2 well-documented case reports of cholestasis in association with transplacental and transmammary carbamazepine exposure. CONCLUSIONS: Carbamazepine-induced hepatitis may occur in association with prenatal exposure and breast feeding. This may expose infants to unnecessary diagnostic procedures, and should therefore be mentioned in the company's product information.

Fibrosing cholestatic hepatitis: Clinical features, outcome and response to interferon and ribavirin

2001 ◽  
Vol 120 (5) ◽  
pp. A563-A564
Author(s):  
M ISMAIL ◽  
I DABOUL ◽  
B WATERS ◽  
J FLECKENSTEIN ◽  
S VERA ◽  
...  
Keyword(s):  
Clinical Features ◽  
Cholestatic Hepatitis

Hubungan Antara Menyusui Dengan Involusi Uterus Pada Ibu Nifas Fisiologis Di RSIA Aura Syifa Kabupaten Kediri

1970 ◽  
Vol 5 (2) ◽  
pp. 64
Author(s):  
Eny Sendra ◽  
Dewi Indriani
Keyword(s):  
Breast Feeding ◽  
Sampling Technique ◽  
Chi Square ◽  
Cross Sectional ◽  
Fisher Test ◽  
Key Word ◽  
Chi Square Test ◽  
The Moment

Breast feeding is giving milk to be drunk to the baby from the breast. Uterus involution is a process how the uterus return to the condition back, before pregnanting after bearing. At the moment of suckling, happens a stimulus and brings the hormones out, such as oksitosin uses not only to stimulate some muscles constraction but also to stimulate the uterus, so that the process of uterus involution happens foster. According to the explanations above, the research aimed to know about the correlation between breast feeding and uterus involution. This research’s design was, cross sectional by the population of all childbirth mothers approximately 50 persons / month. By using accidental sampling technique we got 21 sample respondents. The place of research in RSIA Aura Syifa in Kediri Regency on 16th until 22nd of June 2009. From this research’s result, we got 14 persons (66,67%) with normal uterus involution, suckled in a good way, one person (4,67%) with normal uterus involution, suckled in a wrong way, 2 persons (9,52%) with abnormal uterus involution, suckled in a good way and 4 persons (19,05%) with abnormal uterus involution, suckled in a wrong way. Statistic test which used chi-square test, counted the probability frequency in advance, from that we got 3 columns with the score, less than 5, so that chi-square can not be continued and by doing exact fisher test, the score was 0,001. Because P with the grade mistake 0,05 smaller, so the conclusion was “Ho” is rejected, it meant “there was correlation between suckling and uterus involution”. Key Word : Breast feeding, uterus involution

A case of acute cholestatic hepatitis induced by Corydalis speciosa Max

2009 ◽  
Vol 15 (4) ◽  
pp. 517 ◽  
Author(s):  
Hyun Seok Kang ◽  
Hyuk Soon Choi ◽  
Tae Jung Yun ◽  
Kwang Gyun Lee ◽  
Yeon Seok Seo ◽  
...  
Keyword(s):  
Cholestatic Hepatitis
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