How well can quantitative 24-hour intraesophageal pH monitoring distinguish various degrees of reflux disease?

1995 ◽  
Vol 40 (6) ◽  
pp. 1317-1324 ◽  
Author(s):  
G. Ghillebert ◽  
A. M. Demeyere ◽  
J. Janssens ◽  
G. Vantrappen
Keyword(s):  
Reflux Disease ◽  
Ph Monitoring ◽  
Intraesophageal Ph Monitoring

Gastroesophageal Reflux Disease and Idiopathic Lung Fibrosis. From Heartburn to Lung Transplant, and Beyond

2021 ◽  
pp. 000313482199868
Author(s):  
Fernando A. M. Herbella ◽  
Marco G. Patti
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Lung Fibrosis ◽  
Bronchiolitis Obliterans ◽  
Lung Transplant ◽  
Ph Monitoring ◽  
Objective Evaluation ◽  
Bronchiolitis Obliterans Syndrome ◽  
Laparoscopic Operation

Idiopathic pulmonary fibrosis (IPF) and gastroesophageal reflux disease (GERD) are undoubtedly related. Even though it is not clear yet which one is the primary disease, they certainly interact increasing each other’s severity. Symptoms are unreliable to diagnose GERD in patients with IPF, and objective evaluation with pH monitoring and/or bronchoalveolar lavage analysis is mandatory. Pharmacological treatment with proton pump inhibitors (PPIs) may bring control of IPF in few patients, but PPIs do not control reflux but just change the pH of the gastric refluxate. Surgical therapy based on a fundoplication is safe and effective as it controls any type of reflux, independently from the pH of the gastric refluxate. In patients waiting for lung transplantation (if they can tolerate a laparoscopic operation under general anesthesia), a fundoplication before the operation might block the progression of IPF, while after transplantation it might prevent rejection by preventing the bronchiolitis obliterans syndrome.

Evaluation of Proton Pump Inhibitor-Resistant Nonerosive Reflux Disease by Esophageal Manometry and 24-Hour Esophageal Impedance and pH Monitoring

Digestion ◽  
2015 ◽  
Vol 91 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Osamu Kawamura ◽  
Hiroko Hosaka ◽  
Yasuyuki Shimoyama ◽  
Akiyo Kawada ◽  
Shiko Kuribayashi ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Disease ◽  
Esophageal Manometry ◽  
Ph Monitoring ◽  
Nonerosive Reflux Disease ◽  
Esophageal Impedance
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