Stimulation of phosphate excretion by the renal arterial infusion of 3′5′-AMP (cyclic AMP)—A possible mechanism of action of parathyroid hormone

1968 ◽  
Vol 2 (S1) ◽  
pp. 54-54 ◽  
Author(s):  
R. G. G. Russell ◽  
P. A. Casey ◽  
H. Fleisch
Keyword(s):  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Mechanism Of Action ◽  
Arterial Infusion ◽  
Phosphate Excretion ◽  
Stimulation Of

Lithium administration and phosphate excretion

1976 ◽  
Vol 231 (4) ◽  
pp. 1140-1146 ◽  
Author(s):  
JA Arruda ◽  
JM Richardson ◽  
JA Wolfson ◽  
L Nascimento ◽  
DR Rademacher ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Renal Cortex ◽  
Cyclic Adenosine Monophosphate ◽  
Fractional Excretion ◽  
Adenosine Monophosphate ◽  
Adenyl Cyclase ◽  
Phosphate Excretion ◽  
Camp System

The phosphaturic effect of parathyroid hormone (PTH), cyclic adenosine monophosphate (cAMP), acetazolamide (Az), and HCO3 loading was studied in normal, thyroparathyroidectomized (TPTX), and Li-treated dogs. PTH administration to normal animals markedly increased fractional excretion (F) of PO4 but had a blunted effect on FPO4 in the Li-treated animals. Cyclic AMP likewise markedly increased FPO4 in the normal animals but had a markedly blunted effect in the Li-treated animals. Az led to a significant increase in FNa, FHCO3, and FPO4 in the normal animals. In the Li-treated dogs, Az induced a significant natriuresis and bicarbonaturia but failed to increase phosphaturia. HCO3 loading in normal dogs caused a significant phosphaturia while having little effect on FPO4 in Li-treated dogs. HCO3 loading to TPTX dogs was associated with a lower FPO4 as compared to normal HCO3-loaded animals. These data suggest that Li administration not only blocks the adenyl cyclase-cAMP system in the renal cortex, but it may also interfere with a step distal to the formation of cAMP, since the phosphaturic effect of both PTH and cAMP was markedly diminished in Li-treated animals.

Stimulation of chick adrenal steroidogenesis by avian parathyroid hormone

1988 ◽  
Vol 116 (1) ◽  
pp. 91-95 ◽  
Author(s):  
J. Rosenberg ◽  
M. Pines ◽  
S. Hurwitz
Keyword(s):  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Cyclic Amp ◽  
Steroid Hormone ◽  
Hormone Secretion ◽  
Peptide Hormone ◽  
Adrenocortical Cells ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Stimulation Of

ABSTRACT Dispersed chick adrenocortical cells were incubated with avian parathyroid hormone (aPTH) or ACTH. Accumulation of cyclic AMP (cAMP), activity of cAMP-dependent protein kinase and the secretion of corticosterone and aldosterone, in response to these hormones, were measured. Accumulation of cAMP and activity of cAMP-dependent protein kinase were stimulated by both aPTH and ACTH as well as by cholera toxin. Cyclic AMP production followed a similar time-course when stimulated by either peptide hormone. Stimulation of steroid hormone secretion was detectable after 20 min of incubation with ACTH, but only after 40 min with aPTH. The maximal steroid hormone secretion by adrenocortical cells was similar when induced by either peptide hormone. The aPTH concentrations needed for half-maximal response of corticosterone and aldosterone secretion were higher than those for ACTH (2·5- and 2-fold respectively), but still within the physiological range. The 11β-hydroxylase inhibitor metyrapone inhibited the secretion of both corticosterone and aldosterone when induced by either aPTH or ACTH. The results suggest that aPTH is almost as potent as ACTH in stimulating the secretion of corticosterone and aldosterone from chick adrenocortical cells and utilizes a cAMP-dependent pathway similar to that of ACTH. J. Endocr. (1988) 116, 91–95

THE MECHANISM OF ACTION OF PARATHYROID HORMONE: LACK OF EVIDENCE FOR THE MEDIATION BY CYCLIC ADENOSINE 3′, 5′-MONOPHOSPHATE OF PARATHYROID HORMONE-STIMULATED PHOSPHATURIA

1970 ◽  
Vol 46 (2) ◽  
pp. 185-190 ◽  
Author(s):  
J. D. SALLIS
Keyword(s):  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Mechanism Of Action ◽  
Kidney Tissue ◽  
Adenyl Cyclase ◽  
Cyclase Activity ◽  
Kidney Cortex ◽  
Adenyl Cyclase Activity

SUMMARY The excretion of phosphate in the rat after renal infusion of parathyroid hormone or cyclic adenosine 3,′5′-monophosphate (AMP) is described. The hormone stimulated an immediate phosphaturia, but no such response was measurable in the presence of cyclic AMP. Adenyl cyclase activity in kidney cortex was assessed by measuring the conversion of [14C]adenosine 5′-triphosphate to [14C]cyclic AMP. Previous infusion of kidneys with parathyroid hormone did not alter adenyl cyclase activity but the addition of the hormone to kidney tissue in vitro caused a significant increase in the activity of this enzyme. It is suggested that the parathyroid hormone-stimulated phosphaturia is not mediated by cyclic AMP.

Effects of PTH, ADH, and cyclic AMP on distal tubular Ca and Na reabsorption

1980 ◽  
Vol 239 (5) ◽  
pp. F478-F485 ◽  
Author(s):  
L. S. Costanzo ◽  
E. E. Windhager
Keyword(s):  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Antidiuretic Hormone ◽  
Cyclic Nucleotides ◽  
Adenosine Monophosphate ◽  
Water Reabsorption ◽  
Ca Transport ◽  
Distal Tubules ◽  
Stimulation Of

Tubular microperfusion experiments were performed in rats to examine the effects of thyroparathyroidectomy (TPTX), parathyroid hormone (PTH), antidiuretic hormone (ADH), and cyclic AMP (cAMP) on distal tubular Ca, Na, and water reabsorption. TPTX caused a significant decrease in the Ca reabsorptive rate as compared to intact animals. PTH (5 U/kg; 2 U x kg-1 x h-1) replacement in TPTX animals restored Ca transport to control levels. Application of either cAMP (10(-3) M) or 8-(p-chlorophenylthio)-cyclic 3',5'-adenosine monophosphate (10(-5) M) to the surface of the kidney caused a stimulation of Ca reabsorption similar to that produced by PTH. Neither TPTX nor PTH changed Na or water reabsorption significantly, whereas the cyclic nucleotides increased both of these parameters. These later actions of cAMP duplicated effects of ADH observed in these distal tubules.

Bradykinin stimulates prostaglandin E2 formation in isolated human osteoblast-like cells

1990 ◽  
Vol 10 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Östen Ljunggren ◽  
Jan Rosenquist ◽  
Maria Ransjö ◽  
Ulf H. Lerner
Keyword(s):  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Prostaglandin E2 ◽  
Trabecular Bone ◽  
Human Osteoblast ◽  
Human Osteoblasts ◽  
Human Trabecular Bone ◽  
Stimulation Of ◽  
In Cells

The effect of bradykinin on prostaglandin E2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast-like cells. In these isolated human osteoblast-like cells, bradykinin (1 μmol/l) caused a rapid (5 min) stimulation of prostaglandin E2 formation. This finding indicates that human osteoblasts are equipped with receptors for bradykinin linked to an increase in prostaglandin formation.

scholarly journals Stimulatory effect of prostaglandin E2 on 1α,25-dihydroxyvitamin D3 synthesis in rats

1983 ◽  
Vol 216 (1) ◽  
pp. 237-240 ◽  
Author(s):  
M Yamada ◽  
T Matsumoto ◽  
N Takahashi ◽  
T Suda ◽  
E Ogata
Keyword(s):  
Vitamin D ◽  
Cyclic Amp ◽  
Prostaglandin E2 ◽  
Vitamin D3 ◽  
Arterial Infusion ◽  
Dihydroxyvitamin D3 ◽  
Significant Stimulation ◽  
Urinary Cyclic Amp ◽  
Stimulation Of

The effect of prostaglandin E2 on accumulation in plasma of 1 alpha,25-dihydroxy[3H]vitamin D3 from 25-hydroxy[3H]vitamin D3 was studied in vivo using vitamin D-deficient thyroparathyroidectomized rats. Intra-arterial infusion of 10-50 micrograms of prostaglandin E2/h caused a significant stimulation of 1 alpha,25-dihydroxy[3H]vitamin D3 production. No significant changes in plasma Ca2+ and Pi concentrations or urinary cyclic AMP excretion were observed after prostaglandin E2 infusion. Theophylline did not enhance the effect of a submaximal dose of prostaglandin E2 on 1 alpha,25-dihydroxy[3H]vitamin D3 production. These data indicate that prostaglandin E2 stimulates plasma accumulation of 1 alpha,25-dihydroxy[3H]vitamin D3 independent of the adenylate cyclase/cyclic AMP system, and suggest that prostaglandin E2 has a modulatory role in the regulation of 25-hydroxyvitamin D3 1 alpha-hydroxylase in the kidney.

Parathyroid hormone stimulation of mitosis in rat thymic lymphocytes is independent of cyclic AMP

2009 ◽  
Vol 2 (4) ◽  
pp. 303-309 ◽  
Author(s):  
M.J. Atkinson ◽  
R.-D. Hesch ◽  
C. Cade ◽  
M. Wadwah ◽  
A.D. Perris
Keyword(s):  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Hormone Stimulation ◽  
Stimulation Of
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