Kinetics of amine-inhibited naphthalene hydroxylation by rat liver microsomal cytochrome P-450

1976 ◽  
Vol 5 (3) ◽  
pp. 359-366 ◽  
Author(s):  
A. A. Akhrem ◽  
S. A. Usanov ◽  
D. I. Metelitsa
Keyword(s):  
Rat Liver ◽  
Microsomal Cytochrome ◽  
Kinetics Of ◽  
Cytochrome P 450

Molecular Multiplicity and Gene Structure of Microsomal Cytochrome P-450 in Rat Liver

1985 ◽  
pp. 157-169
Author(s):  
Yoshiaki Fujii-Kuriyama ◽  
Kazuhiro Sogawa ◽  
Yuzuru Mizukami ◽  
Yorimasa Suwa ◽  
Masami Muramatsu ◽  
...  
Keyword(s):  
Rat Liver ◽  
Gene Structure ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450

Induction of rat liver microsomal cytochrome P-450 by muscone (3-methylcyclopentadecanone)

1986 ◽  
Vol 35 (8) ◽  
pp. 1391-1394 ◽  
Author(s):  
Peng Renxiu ◽  
Zhu Xiu-Yuan ◽  
Chung S. Yang
Keyword(s):  
Rat Liver ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450

scholarly journals Kinetics of liver microsomal cholecalciferol 25-hydroxylase in vitamin D-depleted and -repleated rats

1978 ◽  
Vol 172 (3) ◽  
pp. 417-422 ◽  
Author(s):  
E E Delvin ◽  
A Arabian ◽  
F H Glorieux
Keyword(s):  
Vitamin D ◽  
Rat Liver ◽  
Vitamin D Intake ◽  
No Inhibition ◽  
Normal Vitamin ◽  
Kinetics Of ◽  
Cytochrome P 450 ◽  
Generating System

Kinetics of vitamin D-depleted and -repleted rat liver microsomal cholecalciferol 25-hydroxylase were studied. Anaerobiosis, CO, omission of a NADPH-generating system and addition of detergents all decreased the activities, showing that the hydroxylase behaves like a cytochrome P-450-dependent enzyme. An apparent Km of 0.18 micrometer and Vmax. of 32pmol/min per g of tissue were found for vitamin D-deficient animals. Although both apparent Km and Vmax. were significantly altered in vitamin D-repleted animals no inhibition of the enzyme was elicited. These latter results show that at normal vitamin D intake, rat liver cholecalciferol 25-hydroxylase is not feedback-inhibited.

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