scholarly journals Endothelin-1-induced constriction in the coronary resistance vessels and abdominal aorta of the guinea pig

1990 ◽  
Vol 5 (4) ◽  
pp. 206-211 ◽  
Author(s):  
Anne Folta ◽  
Irving G. Joshua ◽  
R. Clinton Webb
Keyword(s):  
Guinea Pig ◽  
Abdominal Aorta ◽  
Coronary Resistance ◽  
Endothelin 1 ◽  
Resistance Vessels

scholarly journals Dilator actions of endothelin in coronary resistance vessels and the abdominal aorta of the guinea pig

Life Sciences ◽  
1989 ◽  
Vol 45 (26) ◽  
pp. 2627-2635 ◽  
Author(s):  
Anne Folta ◽  
Irving G. Joshua ◽  
R. Clinton Webb
Keyword(s):  
Guinea Pig ◽  
Abdominal Aorta ◽  
Coronary Resistance ◽  
Resistance Vessels

Microvascular and myocardial contractile responses to ischemia: influence of exercise training

2000 ◽  
Vol 88 (2) ◽  
pp. 433-442 ◽  
Author(s):  
J. David Symons ◽  
Stephen V. Rendig ◽  
Charles L. Stebbins ◽  
John C. Longhurst
Keyword(s):  
Exercise Training ◽  
Contractile Function ◽  
Treadmill Running ◽  
Ischemia And Reperfusion ◽  
Coronary Resistance ◽  
Short Term ◽  
Endothelin 1 ◽  
Resistance Vessels ◽  
Myocardial Contractile

We hypothesized that exercise training preserves endothelium-dependent relaxation, lessens receptor-mediated constriction of coronary resistance arteries, and reduces myocardial contractile dysfunction in response to ischemia. After 10 wk of treadmill running or cage confinement, regional and global indexes of left ventricular contractile function were not different between trained and sedentary animals in response to three 15-min periods of ischemia (long-term; n = 17), one 5-min bout of ischemia (short-term; n = 18), or no ischemia (sham-operated; n = 24). Subsequently, coronary resistance vessels (∼106 ± 4 μm ID) were isolated and studied using wire myographs. Maximal ACh-evoked relaxation was ∼25, 40, and 60% of KCl-induced preconstriction after the long-term, short-term, and sham-operated protocols, respectively, and was similar between groups. Maximal sodium nitroprusside-evoked relaxation also was similar between groups among all protocols, and vasoconstrictor responses to endothelin-1 and U-46619 were not different in trained and sedentary rats after short-term ischemia or sham operation. We did observe that, after long-term ischemia, maximal tension development in response to endothelin-1 and U-46619 was blunted ( P < 0.05) in trained animals by ∼70 and ∼160%, respectively. These results support our hypothesis that exercise training lessens receptor-mediated vasoconstriction of coronary resistance vessels after ischemia and reperfusion. However, training did not preserve endothelial function of coronary resistance vessels, or myocardial contractile function, after ischemia and reperfusion.

Peptidergic control of coronary resistance vessels

2011 ◽  
Author(s):  
György L. Nádasy ◽  
Mária Szekeres ◽  
Balázs Sachs ◽  
Violetta Kékesi ◽  
László Hunyady ◽  
...  
Keyword(s):  
Coronary Resistance ◽  
Resistance Vessels

Impaired Endothelium-Dependent Vasodilation of Coronary Resistance Vessels Is Associated With Exercise-Induced Myocardial Ischemia

Circulation ◽  
1995 ◽  
Vol 91 (9) ◽  
pp. 2345-2352 ◽  
Author(s):  
Andreas M. Zeiher ◽  
Thomas Krause ◽  
Volker Schächinger ◽  
Jan Minners ◽  
Ernst Moser
Keyword(s):  
Myocardial Ischemia ◽  
Coronary Resistance ◽  
Resistance Vessels ◽  
Exercise Induced

Bronchopulmonary and Pressor Activities of Endothelin-1 (ET-1), ET-2, ET-3, and Big ET-1 in the Guinea Pig

1991 ◽  
Vol 17 ◽  
pp. S326-328 ◽  
Author(s):  
Françoise Pons ◽  
Caroline Touvay ◽  
Vincent Lagente ◽  
Jean Michel Mencia-Huerta ◽  
Pierre Braquet
Keyword(s):  
Guinea Pig ◽  
Endothelin 1

scholarly journals Prostaglandin E2 increases cyclic AMP and inhibits endothelin-1 production/secretion by guinea-pig tracheal epithelial cells through EP4 receptors

2001 ◽  
Vol 132 (5) ◽  
pp. 999-1008 ◽  
Author(s):  
Stéphane Pelletier ◽  
Jean Dubé ◽  
Annie Villeneuve ◽  
Fernand Gobeil ◽  
Quan Yang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Cyclic Amp ◽  
Guinea Pig ◽  
Prostaglandin E2 ◽  
Endothelin 1 ◽  
Tracheal Epithelial Cells ◽  
Tracheal Epithelial

Different mechanisms involved in relaxation of guinea-pig trachea by endothelin-1 and -3

1996 ◽  
Vol 298 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Kamel Hadj-Kaddour ◽  
Alain Michel ◽  
Claude Chevillard
Keyword(s):  
Guinea Pig ◽  
Endothelin 1
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