Photodynamic therapy of colorectal cancer using a new light source

1996 ◽  
Vol 39 (4) ◽  
pp. 379-383 ◽  
Author(s):  
Hanoch Kashtan ◽  
Riad Haddad ◽  
Yoseph Yossiphov ◽  
Shoshana Bar-On ◽  
Yehuda Skornick
Keyword(s):  
Colorectal Cancer ◽  
Photodynamic Therapy ◽  
Light Source

scholarly journals Super Long Green Persistent Luminescence from X-Ray Excited β-NaYF4: Tb3+

2019 ◽  
Author(s):  
Yue Hu ◽  
Yanmin Yang ◽  
Xiaoxiao Li ◽  
Xin Wang ◽  
Yunqian Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Source ◽  
Green Emission ◽  
Persistent Luminescence ◽  
Tunneling Model ◽  
X Ray ◽  
Long Afterglow ◽  
Photo Stability ◽  
F Centers

Here, we have discovered a X-ray excited long afterglow phosphor β-NaYF4: Tb3+. After the irradiation of X-ray, the green emission can persist for more than 240 h. After 36 h, the afterglow intensity arrived at 0.69 mcd•m-2, which can clearly be observed by naked eyes. Even after 84 h, the afterglow emission brightness still reached 0.087 mcd•m-2. Also, combined with the results of thermoluminescence and photoluminescence, the super long afterglow emission of β-NaYF4: Tb3+ can be ascribed to the tunneling model associated with F centers. More importantly, the super long green afterglow emission of β-NaYF4: Tb3+ has been successfully used as in vivo light source to activate g-C3N4 for photodynamic therapy（PDT）and bacteria destruction. Furthermore, super long persistent luminescence of β-NaYF4: Tb3+ could be repeatedly charged by X-ray for many circulations, which indicates that the phosphors have high photo stability under repeated cycles of alternating X-ray irradiation.

scholarly journals Photodynamic Therapy for Advanced Rectal Cancer: A Case Report

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Lemei Chen ◽  
Yanping Liu ◽  
Ping Xie ◽  
Huizhen Fan
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Photodynamic Therapy ◽  
Palliative Treatment ◽  
Treatment Process ◽  
Advanced Colorectal Cancer ◽  
Advanced Rectal Cancer ◽  
Tumor Treatment ◽  
Potential Value ◽  
Case Data

Objective: To investigate the potential value of PDT(photodynamic therapy) in the treatment of rectal cancer by reviewing the diagnosis and treatment process of a patient with advanced rectal cancer who lost the opportunity of surgery. Methods: Select the case data of a patient receiving photodynamic therapy in our hospital, and analyze the photodynamic mechanism, safety and efficiency, and discuss the efficacy of photodynamic therapy. Results: After the patient received photodynamic therapy, re-examination of the endoscopy showed that the intestinal cavity was smoother than before, the bowel was difficult, and the symptoms of blood in the stool improved. Conclusion: Photodynamic therapy can be used as a radical or palliative treatment for clinical tumor treatment. Because of its advantages of minimally invasive, tissue-specific, repetitive and synergistic radiotherapy and chemotherapy, it plays an important role in early or middle-advanced colorectal cancer and is worthy of clinical promotion.

Immunological Aspects of Photodynamic Therapy of Liver Tumors in a Rat Model for Colorectal Cancer ¶

2007 ◽  
Vol 78 (3) ◽  
pp. 235-240
Author(s):  
Frederieke H. Van Duijnhoven ◽  
Remco I. J. M. Aalbers ◽  
Jeroen P. Rovers ◽  
Onno T. Terpstra ◽  
Peter J. K. Kuppen
Keyword(s):  
Colorectal Cancer ◽  
Photodynamic Therapy ◽  
Rat Model ◽  
Liver Tumors

scholarly journals Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment

2019 ◽  
Vol 20 (5) ◽  
pp. 1148 ◽  
Author(s):  
Chun-Chen Yang ◽  
Wei-Yun Wang ◽  
Feng-Huei Lin ◽  
Chun-Han Hou
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Light Source ◽  
Reactive Oxygen ◽  
Blood Analysis ◽  
Oxygen Species ◽  
Tumor Treatment ◽  
X Ray

Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO3 (CaCO3:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO3:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO3:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO3:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO3:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H&E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO2 generation by CaCO3:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment.

Photodynamic therapy in colorectal cancer treatment—The state of the art in preclinical research

2016 ◽  
Vol 13 ◽  
pp. 158-174 ◽  
Author(s):  
Aleksandra Kawczyk-Krupka ◽  
Andrzej M. Bugaj ◽  
Wojciech Latos ◽  
Katarzyna Zaremba ◽  
Katarzyna Wawrzyniec ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
State Of The Art ◽  
The State ◽  
Preclinical Research ◽  
Colorectal Cancer Treatment
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