Prognostic value of the histochemical expression of Helix pomatia agglutinin in advanced colorectal cancer

1994 ◽  
Vol 37 (2) ◽  
pp. 181-184 ◽  
Author(s):  
Yoichi Ikeda ◽  
Masaki Mori ◽  
Yosuke Adachi ◽  
Tetsuya Matsushima ◽  
Keizo Sugimachi
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Advanced Colorectal Cancer ◽  
Helix Pomatia ◽  
Helix Pomatia Agglutinin

Evaluation of systemic inflammation-based prognostic scores in patients with advanced colorectal cancer receiving palliative pelvic radiotherapy (RT).

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 558-558
Author(s):  
Ross Dolan ◽  
Nicholas James MacLeod ◽  
Stephen Thomas McSorley ◽  
Paul G. Horgan ◽  
Barry Laird ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systemic Inflammation ◽  
Prognostic Value ◽  
Advanced Colorectal Cancer ◽  
Prognostic Score ◽  
Glasgow Prognostic Score ◽  
Significant Variable ◽  
Cox Regression Analysis ◽  
Medical Comorbidities ◽  
Male Sex

558 Background: The presence of a systemic inflammatory response (SIR) in patients with advanced cancer is an increasingly recognised prognostic domain and is commonly assessed by the Glasgow Prognostic Score (GPS) and the Neutrophil Lymphocyte Ratio (NLR). However, little work has been carried out to evaluate their role in the field of palliative RT. The aim of the present study was to compare the prognostic value of the GPS and NLR in patients with advanced colorectal cancer receiving palliative pelvic RT. Methods: From a database of all patients undergoing RT in the West of Scotland (2010-2015) patients receiving palliative pelvic RT for colorectal cancer were examined (n = 175). Patients were excluded if they died within 30 days of treatment (n = 15). Demographic data, time from treatment to death/last clinic visit, medical comorbidities, tumour and RT location/dose, CRP, albumin, and differential blood counts were all recorded. GPS, mGPS and NLR were calculated and Cox regression analysis conducted in SPSS. Results: Of the remaining 160 analysed 85 (53%) were male and the median age was 77 (Range: 34-98). The most common clinical indications for palliative radiotherapy were pain (n = 78), bleeding (n = 71) and obstruction/tenesmus (n = 29). Medical comorbidities varied with the most common being hypertension (n- = 75), IHD (n = 36) and diabetes (n = 19). At the time of analysis 130 (81%) of the patients were dead with median survival of 9 months (Range: 1-62 months). On univariate survival analysis Male sex (p = 0.021), GPS (p = 0.015), mGPS (p = 0.028) and NLR ≥ 5 (p = 0.045) but not age > 75 (p = 0.059), Tumour Site (p = 0.637), Performance Status (p = 0.747), ASA (p = 0.525), Delivered Fractions of Radiotherapy (p = 0.062), Dose of RT (p = 0.486) and low Haemoglobin (p = 0.383) were significantly associated with poor survival. On multivariate analysis of the significant variable only male sex (HR: 1.59, 95%CI 1.07-2.36, p = 0.021) and the GPS (HR: 1.47, 95%CI 1.09-1.98, p = 0.011) remained independently associated with survival. Conclusions: In the palliative RT setting systemic inflammation based scores (GPS, mGPS and NLR) had prognostic value and the GPS had independent prognostic value.

Proteome analysis of metastatic colorectal cancer cells recognized by the lectin Helix pomatia agglutinin (HPA)

PROTEOMICS ◽  
2007 ◽  
Vol 7 (22) ◽  
pp. 4082-4089 ◽  
Author(s):  
Julien Saint-Guirons ◽  
Elton Zeqiraj ◽  
Udo Schumacher ◽  
Pamela Greenwell ◽  
Miriam Dwek
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Cells ◽  
Helix Pomatia ◽  
Proteome Analysis ◽  
Helix Pomatia Agglutinin ◽  
Colorectal Cancer Cells

Prognostic value of thymidine phosphorylase/PD-ECGF in advanced colorectal cancer after surgery

2001 ◽  
Vol 120 (5) ◽  
pp. A262-A262
Author(s):  
Y TOKUNAGA ◽  
H HOSOGI ◽  
T HOPPOU ◽  
M NAKAGAMI ◽  
A TOKUKA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Thymidine Phosphorylase ◽  
Advanced Colorectal Cancer

scholarly journals The prognostic value of CEA, βHCG, AFP, CA125, CA19-9 and C-erb B-2, (βHCG immunohistochemistry in advanced colorectal cancer

1995 ◽  
Vol 6 (6) ◽  
pp. 581-587 ◽  
Author(s):  
A. Webb ◽  
P. Scott-Mackie ◽  
D. Cunningham ◽  
A. Norman ◽  
J. Andreyev ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Advanced Colorectal Cancer

Prognostic value of thymidine phosphorylase/PD-ECGF in advanced colorectal cancer after surgery

2001 ◽  
Vol 120 (5) ◽  
pp. A262
Author(s):  
Yukihiko Tokunaga ◽  
Hisahiro Hosogi ◽  
Toshitaka Hoppou ◽  
Mikio Nakagami ◽  
Atsuo Tokuka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Thymidine Phosphorylase ◽  
Advanced Colorectal Cancer

scholarly journals Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer: a post hoc analysis of two non-randomized phase II trials

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Nicolas Charette ◽  
Caroline Vandeputte ◽  
Lieveke Ameye ◽  
Camille Van Bogaert ◽  
Jonathan Krygier ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Muscle Mass ◽  
Phase Ii ◽  
Prognostic Value ◽  
Advanced Colorectal Cancer ◽  
Phase Ii Trials ◽  
Post Hoc Analysis ◽  
Randomized Phase Ii ◽  
Post Hoc
Sign in / Sign up

Export Citation Format

Share Document