Familial goiter with diminished synthesis of thyroglobulin

1969 ◽  
Vol 150 (3) ◽  
pp. 203-212 ◽  
Author(s):  
Frank A. Riddick ◽  
Kavas B. Desai ◽  
John B. Stanbury ◽  
Paul J. Murison
Keyword(s):  
Familial Goiter

A Defective Thyroid Peroxidase Solubilized from a Familial Goiter with Iodine Organification Defect

1974 ◽  
Vol 39 (1) ◽  
pp. 69-80 ◽  
Author(s):  
J. POMMIER ◽  
J. TOURNIAIRE ◽  
D. DÉME ◽  
D. CHALENDAR ◽  
H. BORNET ◽  
...  
Keyword(s):  
Thyroid Peroxidase ◽  
Organification Defect ◽  
Familial Goiter

Peroxidase Deficiency in Familial Goiter with Iodide Organification Defect

1971 ◽  
Vol 285 (25) ◽  
pp. 1394-1398 ◽  
Author(s):  
Garrett A. Hagen ◽  
Hugo Niepomniszcze ◽  
Helmut Haibach ◽  
Mario Bigazzi ◽  
Ratha Hati ◽  
...  
Keyword(s):  
Iodide Organification Defect ◽  
Organification Defect ◽  
Peroxidase Deficiency ◽  
Familial Goiter

Clinical and Morphologic Findings of Familial Goiter in Bongo Antelope (Tragelaphus eurycerus)

1995 ◽  
Vol 32 (3) ◽  
pp. 242-249 ◽  
Author(s):  
C. A. Schiller ◽  
R. J. Montali ◽  
S. Doi ◽  
E. F. Grollman
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Normal Serum ◽  
Follicular Epithelium ◽  
Adult Onset ◽  
Human Beings ◽  
Cyclic Activity ◽  
Congenital Goiter ◽  
Thyroid Glands ◽  
Serum T3 ◽  
Familial Goiter

Inherited defects of thyroglobulin synthesis resulting in congenital goiter are well described in certain breeds of domestic ungulates and in human beings. Goiter associated with synthesis of an abnormal thyroglobulin and the presence of thyroidal albumin was identified in five closely related bongo antelopes ( Tragelaphus eurycerus). The goiter had an adult onset, and the affected bongos appeared to remain euthyroid with normal serum T3 and T4 values, normal serum cholesterol concentrations, and nonelevated concentrations of circulating thyroid stimulating hormone (TSH). Goitrous bongos had significant reproductive difficulties, including reduced cyclic activity and prolonged gestations, but were otherwise normal. Over the course of the disease, the thyroid glands greatly enlarged (up to 10 × 20 cm) and became polycystic. Microscopically, there was an admixture of giant colloid-filled follicles and follicles of normal size lined with variable follicular epithelium ranging from squamoid to mildly to moderately hyperplastic. The pathogenesis of goiter in the bongo may reflect a mixture of genetic predisposition coupled with environmental factors, including a period of exposure to a goitrogen.

The Clinical Chemistry and Pathologic Physiology of Thyroid Tissue

1967 ◽  
Vol 13 (7) ◽  
pp. 542-553 ◽  
Author(s):  
J B Stanbury ◽  
Leslie J DeGroot
Keyword(s):  
Thyroid Hormone ◽  
Malignant Disease ◽  
Clinical Chemistry ◽  
Thyroid Tissue ◽  
Hormone Synthesis ◽  
Peripheral Effect ◽  
Specific Stage ◽  
Criteria For Diagnosis ◽  
Pathologic Physiology ◽  
Familial Goiter

Abstract Familial goiter with hypothyroidism can be subdivided into at least 8 groups and each appears to result from an inherited disorder at a specific stage in thyroid hormone synthesis, mobilization, or peripheral effect. At times, the intense hyperplasia which accompanies one of these disorders evolves into malignant disease. Criteria for diagnosis of each are presented.

Increased level of thyroglobulin mRNA in a human familial goiter

1987 ◽  
Vol 10 (1) ◽  
pp. 59-63
Author(s):  
A. Monticelli ◽  
V. E. Avvedimento ◽  
A. Mariano ◽  
C. Marcocci ◽  
L. Chiovato ◽  
...  
Keyword(s):  
Familial Goiter

Unusual Familial Goiter Associated with Intrathyroidal Calcification1

1966 ◽  
Vol 26 (10) ◽  
pp. 1039-1049 ◽  
Author(s):  
I. P. C. MURRAY ◽  
J. A. THOMSON ◽  
E. M. McGIRR ◽  
ELIZABETH M. MACDONALD ◽  
J. S. KENNEDY ◽  
...  
Keyword(s):  
Familial Goiter

The genetics of euthyroid familial goiter

2005 ◽  
Vol 16 (7) ◽  
pp. 314-319 ◽  
Author(s):  
Yvonne Böttcher ◽  
Markus Eszlinger ◽  
Anke Tönjes ◽  
Ralf Paschke
Keyword(s):  
Familial Goiter

scholarly journals A Premature Stopcodon in Thyroglobulin Messenger RNA Results in Familial Goiter and Moderate Hypothyroidism

1999 ◽  
Vol 84 (7) ◽  
pp. 2537-2542 ◽  
Author(s):  
Simone A. R. van de Graaf ◽  
Carrie Ris-Stalpers ◽  
Geertruda J. M. Veenboer ◽  
Marianne Cammenga ◽  
Cécilia Santos ◽  
...  
Keyword(s):  
Messenger Rna ◽  
Familial Goiter

scholarly journals Association between Alport’s Syndrome and Familial Goiter

Nephron ◽  
1983 ◽  
Vol 35 (3) ◽  
pp. 215-215
Author(s):  
J.P. Gayno ◽  
J.C. Savoie
Keyword(s):  
Alport's Syndrome ◽  
Alport’S Syndrome ◽  
Familial Goiter

Familial goiter with defect in intrinsic metabolism of thyroxine without hypothyroidism

1958 ◽  
Vol 52 (2) ◽  
pp. 129-138 ◽  
Author(s):  
George W. Clayton ◽  
J. Darrel Smith ◽  
Alfred Leiser
Keyword(s):  
Familial Goiter
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