In vitro studies of a bispecific monoclonal antibody antithrombotic conjugate [ATC(3)]

2011 ◽  
Vol 4 (02) ◽  
pp. 83-87 ◽  
Author(s):  
Ranjit More ◽  
Malcolm Underwood ◽  
Michael Brack ◽  
Serena Pringle ◽  
David de Bono ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
In Vitro Studies ◽  
Bispecific Monoclonal Antibody

scholarly journals A critical role of VLA-4 in erythropoiesis in vivo

Blood ◽  
1996 ◽  
Vol 87 (6) ◽  
pp. 2513-2517 ◽  
Author(s):  
K Hamamura ◽  
H Matsuda ◽  
Y Takeuchi ◽  
S Habu ◽  
H Yagita ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Fetal Liver ◽  
Critical Role ◽  
In Utero ◽  
In Vitro Studies ◽  
Specific Interactions ◽  
Erythroid Progenitors

Hematopoiesis requires specific interactions with the microenvironments, and VLA-4 has been implicated in these interactions based on in vitro studies. To study the role of VLA-4 in hematopoiesis in vivo, we performed in utero treatment of mice with an anti-VLA-4 monoclonal antibody. Although all hematopoietic cells in fetal liver expressed VLA-4, the treatment specifically induced anemia. It had no effect on the development of nonerythroid lineage cells, including lymphoids and myeloids. In the treated liver almost no erythroblast was detected, whereas the erythroid progenitors, which give rise to erythroid colonies in vitro, were present. These results indicate that VLA-4 plays a critical role in erythropoiesis, while it is not critical in lymphopoiesis in vivo.

In vivo and in vitro studies with a novel human monoclonal antibody against tetanus neurotoxin

Toxicon ◽  
2013 ◽  
Vol 75 ◽  
pp. 216
Author(s):  
E. Girard ◽  
P. Villeneuve ◽  
V. Devos ◽  
A.S. Dezetter ◽  
A. Fontayne ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Human Monoclonal Antibody ◽  
In Vitro Studies ◽  
Tetanus Neurotoxin

scholarly journals In vitro and in vivo stability and anti-tumour efficacy of an anti-EGFR/anti-CD3 F(ab')2 bispecific monoclonal antibody

1995 ◽  
Vol 72 (4) ◽  
pp. 928-933 ◽  
Author(s):  
DRM Negri ◽  
E Tosi ◽  
O Valota ◽  
S Ferrini ◽  
A Cambiaggi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bispecific Monoclonal Antibody

In vitro studies with an anti-platelet monoclonal antibody; P256

1988 ◽  
Vol 9 (10) ◽  
pp. 813-816 ◽  
Author(s):  
A. W.J. STUTTLE ◽  
J. M. RITTER ◽  
A. M. PETERS ◽  
J. P. LAVENDER
Keyword(s):  
Monoclonal Antibody ◽  
In Vitro Studies

In vitro - studies with antler bone cells: Structure forming capacity, osteocalcin production and influence of sex steroids

2006 ◽  
Vol 15 (04) ◽  
pp. 245-257 ◽  
Author(s):  
H. J. Rolf ◽  
K. G. Wiese ◽  
H. Siggelkow ◽  
H. Schliephake ◽  
G. A. Bubernik
Keyword(s):  
Sex Steroids ◽  
Bone Cells ◽  
In Vitro Studies ◽  
Osteocalcin Production
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