Another look at serum amyloid protein SAA

1983 ◽  
Vol 2 (4) ◽  
pp. 431-433
Author(s):  
M. A. Scheinberg
Keyword(s):  
Serum Amyloid ◽  
Amyloid Protein

scholarly journals PReS-FINAL-2240: Serum amyloid protein a concentration in CAPS patients treated with anti IL1Β

2013 ◽  
Vol 11 (S2) ◽  
Author(s):  
S Pastore ◽  
◽  
G Paloni ◽  
M Gattorno ◽  
A Taddio ◽  
...  
Keyword(s):  
Protein A ◽  
Serum Amyloid ◽  
Amyloid Protein

Monitoring both serum amyloid protein A and C-reactive protein as inflammatory markers in infectious diseases

1993 ◽  
Vol 39 (2) ◽  
pp. 293-297 ◽  
Author(s):  
T Nakayama ◽  
S Sonoda ◽  
T Urano ◽  
T Yamada ◽  
M Okada
Keyword(s):  
Inflammatory Markers ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Protein A ◽  
Acute Stage ◽  
Serum Amyloid ◽  
Amyloid Protein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Mean

Abstract We examined serum amyloid protein A (SAA) and C-reactive protein (CRP) as inflammatory markers of viral and bacterial infections. Both acute-phase reactants increased in the acute stage and thereafter decreased in the convalescent stage. In viral infections, the mean serum concentrations of SAA during the acute stage were 141 mg/L in infections with adenovirus, 77 mg/L with measles virus, 63 mg/L with influenza virus, 55 mg/L with parainfluenza virus, 31 mg/L with respiratory syncytial virus, and 31 mg/L in aseptic meningitis. The mean serum concentration of CRP was 19 mg/L for adenovirus infection and < 7 mg/L in all other viral infections. The SAA concentrations were 5- to 11-fold greater than the CRP concentrations. Both the SAA and the CRP concentrations were higher in bacterial infections than in viral infections. Changes in the concentrations of serum SAA paralleled those in serum CRP in bacterial infection; during the course of viral infection, however, serum SAA tended to disappear more quickly than CRP did. SAA appears to be a clinically useful marker of inflammation in acute viral infections, with or without significant changes in the CRP concentration.

ASSA13-11-7 Distributional Characteristics of Genetic Polymorphisms of Serum Amyloid Protein A1 in Healthy Chinese Han and Uighur Population in Xinjiang

Heart ◽  
2013 ◽  
Vol 99 (Suppl 1) ◽  
pp. A52.3-A53
Author(s):  
Xie Xiang ◽  
Ma Yitong ◽  
Yang Yining ◽  
Liu Fen ◽  
Li Xiaomei ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Serum Amyloid ◽  
Amyloid Protein ◽  
Chinese Han ◽  
Healthy Chinese

scholarly journals Analysis clinical features of COVID-19 infection in secondary epidemic area and report potential biomarkers in evaluation

2020 ◽  
Author(s):  
Weiping Ji ◽  
Gautam Bishnu ◽  
Zhenzhai Cai ◽  
Xian Shen
Keyword(s):  
Respiratory Tract ◽  
Serum Amyloid ◽  
Diagnosis And Treatment ◽  
Amyloid Protein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Epidemic Area ◽  
Systemic Symptoms ◽  
Novel Coronavirus ◽  
Potential Biomarkers

AbstractObjectiveBased on the clinical characteristics of infected patients with novel coronavirus in secondary epidemic areas, we aimed to identify potential biomarkers for the evaluation of novel coronavirus-infected patients, guide the diagnosis and treatment of this disease in secondary epidemic areas and provide a reference for the clinical prevention and control of this epidemic situation.MethodsThe clinical data of 33 patients with respiratory symptoms caused by the novel coronavirus in Wenzhou city from January 15 to February 12, 2020, were thoroughly reviewed. At the onset of the disease, we found that the primary symptoms were fever, cough, fatigue, chest tightness, chest pain and specific blood test results. According to the patients’ histories, the patients were divided into two groups: those who spent time in the main epidemic area and those who did not spend time in the main epidemic area. The differences in the clinical manifestations between these two groups were analyzed.ResultsThe main clinical symptoms of patients infected with novel coronavirus in the secondary epidemic area were respiratory tract ailments and systemic symptoms. After grouping patients based on the presence or absence of residency in or travel history to the main epidemic area, there was no significant difference between the baseline data of these two groups, and there were no significant differences in symptoms and signs between the two groups (P>0.05). Some patients had abnormally increased serum amyloid protein A (SAA). There were statistically significant differences in the leukocyte count/C-reactive protein, monocyte ratio/C-reactive protein, neutrophil count/C-reactive protein, monocyte count/C-reactive protein and hemoglobin/C-reactive protein values between the two groups (P < 0.05).ConclusionRespiratory tract ailments and systemic symptoms were the primary symptoms of novel coronavirus infection in the secondary epidemic area; these symptoms are not typical. The abnormal increase in serum amyloid protein (SAA) may be used as an auxiliary index for diagnosis and treatment. CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection.

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