Photosensitized inhibition of mitogenic stimulation of human lymphocytes by aluminium phthalocyanine tetrasulphonate

1986 ◽  
Vol 1 (3) ◽  
pp. 187-192 ◽  
Author(s):  
R. Kol ◽  
E. Ben-Hur ◽  
E. Riklis ◽  
R. Marko ◽  
I. Rosenthal
Keyword(s):  
Human Lymphocytes ◽  
Mitogenic Stimulation ◽  
Aluminium Phthalocyanine ◽  
Stimulation Of

Prostaglandin E and mitogenic stimulation of human lymphocytes in serum-free medium

1978 ◽  
Vol 15 (3) ◽  
pp. 423-427 ◽  
Author(s):  
Tadao Okazaki ◽  
Masathosi Shimizu ◽  
Carl E. Arbesman ◽  
Elliott Middleton
Keyword(s):  
Human Lymphocytes ◽  
Prostaglandin E ◽  
Serum Free Medium ◽  
Free Medium ◽  
Serum Free ◽  
Mitogenic Stimulation ◽  
Stimulation Of

scholarly journals Reduced mitogenic stimulation of human lymphocytes by extremely low frequency electromagnetic fields

FEBS Letters ◽  
1983 ◽  
Vol 162 (1) ◽  
pp. 156-160 ◽  
Author(s):  
Pio Conti ◽  
Giovanni Ettore Gigante ◽  
Maria Grazia Cifone ◽  
Edoardo Alesse ◽  
Gianfranco Ianni ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Human Lymphocytes ◽  
Low Frequency ◽  
Mitogenic Stimulation ◽  
Extremely Low Frequency ◽  
Stimulation Of

Effects of colchicine and vinblastine on the phytohaemagglutinin-induced transformation of lymphocytes

1977 ◽  
Vol 27 (1) ◽  
pp. 183-198
Author(s):  
J. Thyberg ◽  
S. Moskalewski ◽  
U. Friberg
Keyword(s):  
Cell Growth ◽  
Dna Synthesis ◽  
Golgi Complex ◽  
Human Lymphocytes ◽  
Blast Transformation ◽  
Drug Induced ◽  
Mitogenic Stimulation ◽  
Cytoplasmic Microtubules ◽  
Pha Stimulation ◽  
Stimulation Of

The effects of 2 microtubular-disruptive drugs, colchicine and vinblastine, on the phytohaemagglutinin (PHA)-induced blast transformation and mitogenic stimulation of human lymphocytes were studied. Both drugs markedly inhibited cell growth and DNA synthesis and lowered the mitotic index. No microtubules were seen with the electron microscope in cells treated with PHA plus colchicine or vinblastine. Moreover, the PHA-induced development of all organelles was partially inhibited by these drugs, especially that of the Golgi complex. As compared to cells treated with PHA alone, the dictyosomes were fewer, not so clearly localized in one area of the cytoplasm, and contained a decreased number of cisternae and an increased number of vacuoles. These results indicate that cytoplasmic microtubules play an important role in the PHA-induced blast transformation and mitogenic stimulation of lymphocytes. It is suggested that the microtubules function in the structural organization of the cell and particularly the Golgi complex. In the drug-induced absence of microtubules this and other organelle systems do not respond as usual to PHA stimulation, which could largely explain the decreased cell growth. This in turn suggests that lowered mitotic activity is a result of inhibition of cell growth, as a critical amount of G1-associated cell growth is believed to be required for the initiation of DNA synthesis and thus mitosis.

Sign in / Sign up

Export Citation Format

Share Document