Localizing and photosensitizing mechanism by tetra(3-hydroxyphenyl)porphin in vivo on human malignant melanoma xenografts in athymic nude mice

1990 ◽  
Vol 5 (4) ◽  
pp. 399-409 ◽  
Author(s):  
Q. Peng ◽  
J. Moan ◽  
Jahn M. Nesland ◽  
Jan F. Evensen ◽  
M. Kongshaug ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Nude Mice ◽  
Human Malignant Melanoma ◽  
Athymic Nude Mice

A new experimental metastasis model in athymic nude mice, the human malignant melanoma lox

1988 ◽  
Vol 41 (3) ◽  
pp. 442-449 ◽  
Author(s):  
ØYstein Fodstad ◽  
Steinar Aamdal ◽  
Mary McMenamin ◽  
Jahn M. Nesland ◽  
Alexander Pihl
Keyword(s):  
Malignant Melanoma ◽  
Nude Mice ◽  
Experimental Metastasis ◽  
Human Malignant Melanoma ◽  
Athymic Nude Mice ◽  
Metastasis Model

scholarly journals ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Wei Zhang ◽  
Zhen Chen ◽  
Likun Chen ◽  
Fang Wang ◽  
Furong Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Nude Mice ◽  
Large Cell ◽  
Athymic Nude Mice ◽  
H460 Cell ◽  
Large Cell Lung Cancer ◽  
Cytological Characteristics

Abstract H460/MX20 are derived from large cell lung cancer H460 cell line and then transformed into ABCG2-overexpressing cells by mitoxantrone’s induction, which are widely used in study of multidrug resistance (MDR) in vitro. To establish and spread the model of H460/MX20 cell xenografts, we investigated whether cell biological characteristics and the MDR phenotype were maintained in vivo model. Our results demonstrated that the cell proliferation, cell cycle, and ABCG2 expression level in xH460/MX20 cells isolated from H460/MX20 cell xenografts were similar to H460/MX20 cells in vitro. Importantly, xH460/MX20 cells exhibited high levels of resistance to ABCG2 substrates such as mitoxantrone and topotecan as H460/MX20 cells did. Furthermore, lapatinib, the inhibitor of ABCG2, potently reversed mitoxantrone- and topotecan-resistance of xH460/MX20 cells. Taken together, these results suggest that H460/MX20 cell xenografts in athymic nude mice still retain their original cytological characteristics and MDR phenotype. Thus, the H460/MX20 cell xenografts model could serve as a sound model in vivo for study on reversal MDR.

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