Report of the 14th Meeting of the British Inflammation Research Association Topic: Cellular and molecular aspects of inflammatory bowel disease

1993 ◽  
Vol 38 (S1) ◽  
pp. i-iii
Author(s):  
Gerry Murphy
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Research Association ◽  
Inflammation Research ◽  
British Inflammation ◽  
Inflammation Research Association ◽  
Inflammatory Bowel ◽  
Molecular Aspects

scholarly journals The use of Tofacitinib in the treatment of inflammatory bowel disease

2019 ◽  
Vol 91 (2) ◽  
pp. 101-108 ◽  
Author(s):  
E L Nasonov ◽  
D I Abdulganieva ◽  
I F Fairushina
Keyword(s):  
Inflammatory Bowel Disease ◽  
Small Molecules ◽  
Bowel Disease ◽  
Kinase Inhibitor ◽  
Janus Kinase ◽  
Cytokine Signaling ◽  
Intracellular Cytokine ◽  
New Class ◽  
Inflammatory Bowel ◽  
Molecular Aspects

Major advances in pharmacology of the 21st century include the development of a new class of drugs, which are low-molecular, chemically synthesized molecules (the so-called "small molecules"), the point of application of which is Janus kinase (Janus kinase, JAK) involved in intracellular cytokine signaling. The review examines the molecular aspects of the JAK-STAT signaling pathway, justifying the use of the JAK-kinase inhibitor (tofacitinib) in the treatment of inflammatory bowel disease.

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