Detection of collagen degradation products in bone

1973 ◽  
Vol 12 (1) ◽  
pp. 303-312 ◽  
Author(s):  
Yoshinori Kuboki ◽  
Hitoyata Shimokawa ◽  
Toshio Ono ◽  
Satoshi Sasaki
Keyword(s):  
Degradation Products ◽  
Collagen Degradation ◽  
Collagen Degradation Products

Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes

2005 ◽  
Vol 24 (1) ◽  
pp. 63-70 ◽  
Author(s):  
M. Fichter ◽  
U. Körner ◽  
J. Schömburg ◽  
L. Jennings ◽  
A. A. Cole ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Articular Chondrocytes ◽  
Degradation Products ◽  
Collagen Degradation ◽  
Collagen Degradation Products

Diagnostic Significance of β-Collagen Degradation Products and Osteocalcin in Chronic Obstructive Pulmonary Disease Complicated with Osteoporosis

2021 ◽  
Vol 20 (2) ◽  
pp. 288-292
Author(s):  
Yafeng Ji ◽  
Hongliang Gao ◽  
Yongli Wang ◽  
Xuesheng Jiang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Degradation Products ◽  
Collagen Degradation ◽  
Chronic Obstructive ◽  
Characteristic Analysis ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease ◽  
Predictive Values ◽  
Collagen Degradation Products

Chronic obstructive pulmonary disease is a pulmonary dysfunction common to the middle-aged and elderly population. About 20–60% of patients with moderate or severe chronic obstructive pulmonary disease suffer from different degrees of osteoporosis. A strong relationship between β-collagen degradation products and osteocalcin has been shown in several bone diseases, but their roles in chronic obstructive pulmonary disease remain to be investigated. This study was designed to explore such a relationship in patients with chronic obstructive pulmonary disease complicated with osteoporosis. The β-collagen degradation products were the highest in the serum of patients diagnosed with both chronic obstructive pulmonary disease and osteoporosis followed by those with chronic obstructive pulmonary disease only and osteoporosis only. According to the receiver operating characteristic analysis curves, both β-collagen degradation products and osteocalcin had favorable predictive values for patients with chronic obstructive pulmonary disease, osteoporosis or both. In addition, β-collagen degradation products were negatively correlated with forced expiratory volume in 1 s and bone mineral density, while osteocalcin was positively correlated with them. β-collagen degradation products increase, and osteocalcin decreases in patients with both chronic obstructive pulmonary disease and osteoporosis.

Immunoassay for quantifying type I collagen degradation products in urine evaluated

1994 ◽  
Vol 40 (11) ◽  
pp. 2022-2025 ◽  
Author(s):  
M Bonde ◽  
P Qvist ◽  
C Fledelius ◽  
B J Riis ◽  
C Christiansen
Keyword(s):  
Type I Collagen ◽  
Degradation Products ◽  
Mean Value ◽  
Collagen Degradation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Bone Resorption Marker ◽  
Type I ◽  
Analytical Recovery ◽  
Collagen Degradation Products ◽  
Better Than

Abstract An enzyme-linked immunosorbent assay (ELISA) for measuring type I collagen degradation products in urine < 3 h was evaluated. The measuring range was 0.5-10.5 mg/L with a detection limit of 0.2 mg/L. Within-run and total CVs were 5.3% and 6.6%, respectively. Analytical recovery averaged 100%. The mean (+/- SD) concentrations in urine samples from a healthy premenopausal population (n = 102) were 250 +/- 110 mg/mol creatinine (Cr). A group of healthy postmenopausal women (n = 410) gave a mean value of 416 +/- 189 mg/mol Cr. Values obtained in the ELISA correlated well (r = 0.83) to HPLC values for the established bone resorption marker deoxypyridinoline (n = 214), slightly better than the correlation to hydroxyproline measurements (r = 0.78, n = 421). We conclude that the assay described here presents a useful tool for further elucidating the importance of type I collagen degradation products in urine.

Elastin and collagen degradation products in urine of patients with cystic fibrosis.

1995 ◽  
Vol 152 (1) ◽  
pp. 157-162 ◽  
Author(s):  
P J Stone ◽  
M W Konstan ◽  
M Berger ◽  
H L Dorkin ◽  
C Franzblau ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Degradation Products ◽  
Collagen Degradation ◽  
Collagen Degradation Products

scholarly journals Urinary collagen degradation products as early markers of progressive renal fibrosis

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Ryanne S. Hijmans ◽  
Daniel Guldager Kring Rasmussen ◽  
Saleh Yazdani ◽  
Gerjan Navis ◽  
Harry van Goor ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Degradation Products ◽  
Collagen Degradation ◽  
Early Markers ◽  
Collagen Degradation Products
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