Hyaluronate in articular cartilage: Age-related changes

1978 ◽  
Vol 26 (1) ◽  
pp. 19-21 ◽  
Author(s):  
E. J. -M. A. Thonar ◽  
M. B. E. Sweet ◽  
A. R. Immelman ◽  
G. Lyons
Keyword(s):  
Articular Cartilage ◽  
Age Related ◽  
Age Related Changes

scholarly journals Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

2014 ◽  
Vol 75 (2) ◽  
pp. 449-458 ◽  
Author(s):  
Wang Hui ◽  
David A Young ◽  
Andrew D Rowan ◽  
Xin Xu ◽  
Tim E Cawston ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Signalling Pathways ◽  
Age Related ◽  
Age Related Changes

Age-Related Changes in the Synthesis of Matrix Macromolecules by Bovine Articular Cartilage

1989 ◽  
Vol 19 (2-4) ◽  
pp. 121-133 ◽  
Author(s):  
Philippe Front ◽  
France Aprile ◽  
Dragoslav R. Mitrovic ◽  
David A. Swann
Keyword(s):  
Articular Cartilage ◽  
Bovine Articular Cartilage ◽  
Age Related ◽  
Age Related Changes

CHANGES IN SWINE KNEE ARTICULAR CARTILAGE DURING GROWTH

1979 ◽  
Vol 59 (1) ◽  
pp. 167-179 ◽  
Author(s):  
T. NAKANO ◽  
F. X. AHERNE ◽  
J. R. THOMPSON
Keyword(s):  
Hyaluronic Acid ◽  
Articular Cartilage ◽  
Dry Matter ◽  
Endochondral Ossification ◽  
Keratan Sulfate ◽  
Cartilage Thickness ◽  
Cell Necrosis ◽  
Normal Cartilage ◽  
Age Related ◽  
Age Related Changes

Twenty-five crossbred boars reared under normal conditions were serially slaughtered at the age of 3 days, and 5, 10, 20 and 30 wk. Five boars were slaughtered at each age and morphological, histochemical and biochemical age-related changes in femoral condylar articular cartilage were studied. No osteochondrotic joints were found in pigs 10 wk of age or younger, while 7 of the 10 boars slaughtered at 20 and 30 wk of age were osteochondrotic. Cartilage thickness increased (P < 0.05) until the age of 5 wk and decreased (P < 0.05) thereafter. Cell density decreased (P < 0.05) as age advanced. Age-associated changes found in the chemical composition of the cartilage were an increase in the concentration of dry matter and hydroxyproline and a decrease in the concentration of glycosaminoglycans (GAG) including chondroitin sulfate (ChS), keratan sulfate and hyaluronic acid. The proportions of soluble proteoglycan and 4-sulfated disaccharide from the ChS fraction decreased (P < 0.05) while the proportion of 6-sulfated disaccharide from ChS increased (P < 0.05). Osteochondrosis was observed as a disturbed endochondral ossification, and softening and fracture of the cartilage. The former was accompanied by a loss of intercellular GAG and cell necrosis, and the latter by local losses of GAG and cells. Osteochondrotic cartilage also contained higher proportions of soluble proteoglycan and 6-sulfated disaccharide, and lower proportions of 4-sulfated disaccharide than did the visually normal cartilage.

Age-related Changes in the Antigenicity of Human Articular Cartilage Proteoglycans

1982 ◽  
Vol 2 (1) ◽  
pp. 45-60 ◽  
Author(s):  
Brian R. Champion ◽  
Agnes Reiner ◽  
Peter J. Roughley ◽  
A. Robin Poole
Keyword(s):  
Articular Cartilage ◽  
Human Articular Cartilage ◽  
Age Related ◽  
Cartilage Proteoglycans ◽  
Age Related Changes

scholarly journals Age-related changes in the sulphation of the chondroitin sulphate linkage region from human articular cartilage aggrecan

2001 ◽  
Vol 358 (2) ◽  
pp. 523 ◽  
Author(s):  
Robert M. LAUDER ◽  
Thomas N. HUCKERBY ◽  
Gavin M. BROWN ◽  
Michael T. BAYLISS ◽  
Ian A. NIEDUSZYNSKI
Keyword(s):  
Articular Cartilage ◽  
Chondroitin Sulphate ◽  
Human Articular Cartilage ◽  
Linkage Region ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-related changes in the structure of the keratan sulphate chains attached to fibromodulin isolated from articular cartilage

1998 ◽  
Vol 330 (2) ◽  
pp. 753-757 ◽  
Author(s):  
M. Robert LAUDER ◽  
N. Thomas HUCKERBY ◽  
A. Ian NIEDUSZYNSKI ◽  
H. K. Anna PLAAS
Keyword(s):  
Articular Cartilage ◽  
Anion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Keratan Sulphate ◽  
Bovine Articular Cartilage ◽  
Acetylneuraminic Acid ◽  
Age Related ◽  
Keratanase Ii ◽  
Age Related Changes ◽  
Related Increase

Bovine articular cartilage fibromodulin has been isolated from animals aged 3 months to 8 years, and the attached keratan sulphate (KS) chains digested with keratanase II. The oligosaccharides generated have been reduced, examined by high-pH anion-exchange chromatography and their structures identified by comparison with standards. It has been shown that in fibromodulin from young articular cartilage, the KS chains do not possess either non-reducing terminal (α2-6)-linked N-acetylneuraminic acid or fucose (α1-3)-linked to sulphated N-acetylglucosamine residues. However, an age-related increase has been observed in the abundance of both (α2-6)-linked N-acetylneuraminic acid and (α1-3)-linked fucose, neither of which is found in KS isolated from non-articular cartilage, irrespective of the age of the source. Interestingly, the KS chain length remains constant as a function of age, which possibly relates to a role in collagen fibril assembly. In addition, no significant age-related changes were identified in levels of galactose sulphation.

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