Synergism of basic fibroblast growth factor and interleukin-1β to induce articular cartilage-degradation in the rabbit

1991 ◽  
Vol 34 (1-2) ◽  
pp. 217-219 ◽  
Author(s):  
P. Stevens ◽  
E. M. Shatzen
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Cartilage Degradation ◽  
Interleukin 1Β ◽  
Fibroblast Growth

Basic fibroblast growth factor stimulates articular cartilage enlargement in young ratsin vivo

1996 ◽  
Vol 14 (2) ◽  
pp. 265-272 ◽  
Author(s):  
Jun-Ichi Shida ◽  
Seiya Jingushi ◽  
Toshihiro Izumi ◽  
Akira Iwaki ◽  
Yoichi Sugioka
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth

Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded

2004 ◽  
Vol 50 (2) ◽  
pp. 526-533 ◽  
Author(s):  
Tonia L. Vincent ◽  
Monika A. Hermansson ◽  
Ulrich N. Hansen ◽  
Andrew A. Amis ◽  
Jeremy Saklatvala
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Mechanical Signals

Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?

2006 ◽  
Vol 34 (3) ◽  
pp. 456-457 ◽  
Author(s):  
T. Vincent ◽  
J. Saklatvala
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
Cell Surface ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Articular Chondrocytes ◽  
Heparan Sulphate ◽  
Mechanical Stimuli ◽  
Fibroblast Growth ◽  
Extracellular Signal

Mechanical stimuli are important signals in articular cartilage, but what mediates them is unknown. We have shown that extracellular-signal-regulated kinase was activated on cutting and loading articular cartilage, and deduced that this was due to the release of bFGF (basic fibroblast growth factor) from the tissue. bFGF was shown to be extracellular, and by immunohistochemistry, was present in the pericellular matrix of articular chondrocytes attached to the heparan sulphate proteoglycan perlecan. We propose a novel mechanotransduction model, whereby pericellular bFGF, a short distance from the cell surface, becomes available to the cell surface tyrosine kinase receptors when articular cartilage is loaded.

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